Nanomole-scale high-throughput chemistry for the synthesis of complex molecules A Buitrago Santanilla, EL Regalado, T Pereira, M Shevlin, K Bateman, ... Science 347 (6217), 49-53, 2015 | 561 | 2015 |
Carrageenan-induced paw edema in rat elicits a predominant prostaglandin E2 (PGE2) response in the central nervous system associated with the induction of microsomal PGE2 … J Guay, K Bateman, R Gordon, J Mancini, D Riendeau Journal of Biological Chemistry 279 (23), 24866-24872, 2004 | 316 | 2004 |
MSE with mass defect filtering for in vitro and in vivo metabolite identification KP Bateman, J Castro‐Perez, M Wrona, JP Shockcor, K Yu, R Oballa, ... Rapid Communications in Mass Spectrometry: An International Journal Devoted …, 2007 | 312 | 2007 |
‘All‐in‐one’analysis for metabolite identification using liquid chromatography/hybrid quadrupole time‐of‐flight mass spectrometry with collision energy switching M Wrona, T Mauriala, KP Bateman, RJ Mortishire‐Smith, D O'Connor Rapid Communications in Mass Spectrometry: An International Journal Devoted …, 2005 | 209 | 2005 |
Discovery of a potent and selective prostaglandin D2 receptor antagonist,[(3 R)-4-(4-chloro-benzyl)-7-fluoro-5-(methylsulfonyl)-1, 2, 3, 4-tetrahydrocyclopenta [b] indol-3-yl … CF Sturino, G O'Neill, N Lachance, M Boyd, C Berthelette, M Labelle, L Li, ... Journal of medicinal chemistry 50 (4), 794-806, 2007 | 208 | 2007 |
Quantitative-qualitative data acquisition using a benchtop Orbitrap mass spectrometer KP Bateman, M Kellmann, H Muenster, R Papp, L Taylor Journal of the American Society for Mass Spectrometry 20, 1441-1450, 2009 | 200 | 2009 |
γ-Aminobutyric acid type B receptors with specific heterodimer composition and postsynaptic actions in hippocampal neurons are targets of anticonvulsant gabapentin action GYK Ng, S Bertrand, R Sullivan, N Ethier, J Wang, J Yergey, M Belley, ... Molecular Pharmacology 59 (1), 144-152, 2001 | 188 | 2001 |
Mass spectral analyses of microcystins from toxic cyanobacteria using on-line chromatographic and electrophoretic separations KP Bateman, P Thibault, DJ Douglas, RL White Journal of Chromatography A 712 (1), 253-268, 1995 | 178 | 1995 |
Discovery stage pharmacokinetics using dried blood spots P Beaudette, KP Bateman Journal of Chromatography B 809 (1), 153-158, 2004 | 158 | 2004 |
Deletion of microsomal prostaglandin E2 (PGE2) synthase-1 reduces inducible and basal PGE2 production and alters the gastric prostanoid profile L Boulet, M Ouellet, KP Bateman, D Ethier, MD Percival, D Riendeau, ... Journal of Biological Chemistry 279 (22), 23229-23237, 2004 | 147 | 2004 |
Disposable emitters for on‐line capillary zone electrophoresis/nanoelectrospray mass spectrometry KP Bateman, RL White, P Thibault Rapid communications in mass spectrometry 11 (3), 307-315, 1997 | 135 | 1997 |
Validation of a microdose probe drug cocktail for clinical drug interaction assessments for drug transporters and CYP3A T Prueksaritanont, DA Tatosian, X Chu, R Railkar, R Evers, ... Clinical Pharmacology & Therapeutics 101 (4), 519-530, 2017 | 133 | 2017 |
High-throughput cytochrome P450 inhibition assays using laser diode thermal desorption-atmospheric pressure chemical ionization-tandem mass spectrometry J Wu, CS Hughes, P Picard, S Letarte, M Gaudreault, JF Lévesque, ... Analytical Chemistry 79 (12), 4657-4665, 2007 | 131 | 2007 |
2012 White Paper on recent issues in bioanalysis and alignment of multiple guidelines B DeSilva, F Garofolo, M Rocci, S Martinez, I Dumont, F Landry, C Dicaire, ... Bioanalysis 4 (18), 2213-2226, 2012 | 93 | 2012 |
The YRD motif is a major determinant of substrate and inhibitor specificity in T-cell protein-tyrosine phosphatase E Asante-Appiah, K Ball, K Bateman, K Skorey, R Friesen, C Desponts, ... Journal of Biological Chemistry 276 (28), 26036-26043, 2001 | 77 | 2001 |
Extractability-mediated stability bias and hematocrit impact: high extraction recovery is critical to feasibility of volumetric adsorptive microsampling (VAMS) in regulated … I Xie, Y Xu, M Anderson, M Wang, L Xue, S Breidinger, D Goykhman, ... Journal of pharmaceutical and biomedical analysis 156, 58-66, 2018 | 72 | 2018 |
Catalytic inactivation of protein tyrosine phosphatase CD45 and protein tyrosine phosphatase 1B by polyaromatic quinones Q Wang, D Dubé, RW Friesen, TG LeRiche, KP Bateman, L Trimble, ... Biochemistry 43 (14), 4294-4303, 2004 | 68 | 2004 |
Merck’s perspective on the implementation of dried blood spot technology in clinical drug development–why, when and how Y Xu, EJ Woolf, NGB Agrawal, P Kothare, V Pucci, KP Bateman Bioanalysis 5 (3), 341-350, 2013 | 67 | 2013 |
High-sensitivity nanolc− ms/ms analysis of urinary desmosine and isodesmosine M Boutin, C Berthelette, FG Gervais, MB Scholand, J Hoidal, MF Leppert, ... Analytical chemistry 81 (5), 1881-1887, 2009 | 65 | 2009 |
The use of 3-[2-(N, N-diethyl-N-methylammonium) ethyl]-7-methoxy-4-methylcoumarin (AMMC) as a specific CYP2D6 probe in human liver microsomes N Chauret, B Dobbs, RL Lackman, K Bateman, DA Nicoll-Griffith, ... Drug metabolism and disposition 29 (9), 1196-1200, 2001 | 65 | 2001 |