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Gheorghe Manole
Gheorghe Manole
Dept. of Internal Medicine,Clinical Hospital Colentina, Univ. Bioterra, Faculty of Medicine
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Designing of novel carbonic anhydrase inhibitors and activators
CT Supuran, D Vullo, G Manole, A Casini, A Scozzafava
Current Medicinal Chemistry-Cardiovascular & Hematological Agents 2 (1), 49-68, 2004
1932004
Carbonic anhydrase inhibitors. Inhibition of the cytosolic and tumor-associated carbonic anhydrase isozymes I, II, and IX with a series of 1, 3, 4-thiadiazole-and 1, 2, 4 …
GL Almajan, A Innocenti, L Puccetti, G Manole, S Barbuceanu, I Saramet, ...
Bioorganic & medicinal chemistry letters 15 (9), 2347-2352, 2005
1102005
Inhibition of the β-class carbonic anhydrases from Mycobacterium tuberculosis with carboxylic acids
A Maresca, D Vullo, A Scozzafava, G Manole, CT Supuran
Journal of enzyme inhibition and medicinal chemistry 28 (2), 392-396, 2013
912013
Carbonic anhydrase inhibitors. V: Pyrylium salts in the synthesis of isozyme-specific inhibitors
CT Supuran, G Manole, A Dinculescu, A Schiketanz, MD Gheorghiu, ...
Journal of pharmaceutical sciences 81 (7), 716-719, 1992
581992
Carbonic anhydrase inhibitors. Part 11. Coordination compounds of heterocyclic sulfonamides with lanthanides are potent inhibitors of isozymes I and II
CT Supuran, M Andruh, G Manole
Journal of inorganic biochemistry 49 (2), 97-103, 1993
431993
Carbonic-Anhydrase Inhibitors. 13. Complex-Type Mechanism-Based Inhibitors
CT Supuran
Revue Roumaine de Chimie 37 (7), 849-855, 1992
351992
CARBONIC-ANHYDRASE INHIBITORS. 15. COMPLEX INHIBITORS CONTAINING MAIN-GROUP AND TRANSITIONAL DIVALENT-CATIONS
CT Supuran, G Loloiu, G Manole
Revue Roumaine de Chimie 38 (1), 115-122, 1993
231993
Myeloperoxidase, a possible biomarker for the early diagnosis of cardiac diastolic dysfunction with preserved ejection fraction
BI Coculescu, GV Dincă, C Bălăeţ, G Manole, M Bălăeţ, CM Stocheci
Journal of Enzyme Inhibition and Medicinal Chemistry 33 (1), 1292-1298, 2018
202018
Carbonic anhydrase activators: Activation of the β-carbonic anhydrase from the pathogenic yeast Candida glabrata with amines and amino acids
A Innocenti, W Leewattanapasuk, G Manole, A Scozzafava, ...
Bioorganic & Medicinal Chemistry Letters 20 (5), 1701-1704, 2010
192010
Protease inhibitors: Part 12. Synthesis of potent matrix metalloproteinase and bacterial collagenase inhibitors incorporating sulfonylated N-4-nitrobenzyl-β-alanine hydroxamate …
A Scozzafava, MA Ilies, G Manole, CT Supuran
European journal of pharmaceutical sciences 11 (1), 69-79, 2000
182000
CARBONIC-ANHYDRASE ACTIVATORS. 2. AMINO-ACIDS AND SOME OF THEIR DERIVATIVES MAY ACT AS POTENT ENZYME ACTIVATORS
CT Supuran, A Dinculescu, G Manole, F Savan, I Puscas, AT Balaban
REVUE ROUMAINE DE CHIMIE 36 (8), 937-946, 1991
181991
Osteopontin–a biomarker of disease, but also of stage stratification of the functional myocardial contractile deficit by chronic ischaemic heart disease
BI Coculescu, G Manole, GV Dincă, EC Coculescu, C Berteanu, ...
Journal of Enzyme Inhibition and Medicinal Chemistry 34 (1), 783-788, 2019
172019
Burning mouth syndrome: controversial place as a symptom of Oro-dental pathology
PVL Coculescu E.C., Manole Gh., Coculescu B.I.
J. Med. Life., 8 (Spec Issue), 34-37, 2015
172015
Molecular processes in the streptokinase thrombolytic therapy
C Capitanescu, AM Macovei Oprescu, D Ionita, GV Dinca, C Turculet, ...
Journal of enzyme inhibition and medicinal chemistry 31 (6), 1411-1414, 2016
162016
Lipoprotein-associated phospholipase A2 (Lp-PLA2)–possible diagnostic and risk biomarker in chronic ischaemic heart disease
A Diaconu, BI Coculescu, G Manole, H Vultur, EC Coculescu, ...
Journal of Enzyme Inhibition and Medicinal Chemistry 36 (1), 68-73, 2021
152021
Serum concentration of hsCRP-possible marker for therapy evaluation in left ventricular dysfunction with preserved ejection fraction
BI Coculescu, GV Dinca, G Manole, VL Purcarea, AM Oproiu, ...
Rev. Chim.(Bucharest) 69, 2885-990, 2018
142018
Gamma-glutamyltransferase, possible novel biomarker in colon diverticulosis: a case-control study
C Bălăeţ, BI Coculescu, G Manole, M Bălăeţ, GV Dincă
Journal of enzyme inhibition and medicinal chemistry 33 (1), 428-432, 2018
142018
Carbonic-anhydrase inhibitors. 12. Lanthanide complexes with acetazolamide as dual inhibitors
CT Supuran, G Manole, I Manzatu
Revue Roumaine de Chimie 37 (6), 739-744, 1992
141992
1, 3, 4-Thiadiazole derivatives. 1. Zn (II) and Hg (II) coordination-compounds of 2-amino-5-mercapto-1, 3, 4-thiadiazole as enzyme-inhibitors
M Brezeanu, R Olar, G Manole, CT Supuran
REVUE ROUMAINE DE CHIMIE 37 (4), 425-431, 1992
121992
Carbonic anhydrase inhibitors. Part 3. Relations between chemical structure of inhibitors and activators
I Puscas, CT Supuran, G Manole
Revue Roumaine de Chimie 35, 683-689, 1990
111990
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