| Use of the cell wall precursor lipid II by a pore-forming peptide antibiotic E Breukink, I Wiedemann, C Kraaij, OP Kuipers, HG Sahl, B De Kruijff Science 286 (5448), 2361-2364, 1999 | 1068 | 1999 |
| Specific binding of nisin to the peptidoglycan precursor lipid II combines pore formation and inhibition of cell wall biosynthesis for potent antibiotic activity I Wiedemann, E Breukink, C Van Kraaij, OP Kuipers, G Bierbaum, ... Journal of Biological Chemistry 276 (3), 1772-1779, 2001 | 976 | 2001 |
| Lipid II as a target for antibiotics E Breukink, B de Kruijff Nature reviews Drug discovery 5 (4), 321-323, 2006 | 897 | 2006 |
| The nisin–lipid II complex reveals a pyrophosphate cage that provides a blueprint for novel antibiotics STD Hsu, E Breukink, E Tischenko, MAG Lutters, B De Kruijff, R Kaptein, ... Nature structural & molecular biology 11 (10), 963-967, 2004 | 670 | 2004 |
| An alternative bactericidal mechanism of action for lantibiotic peptides that target lipid II HE Hasper, NE Kramer, JL Smith, JD Hillman, C Zachariah, OP Kuipers, ... Science 313 (5793), 1636-1637, 2006 | 616 | 2006 |
| The lantibiotic nisin, a special case or not? E Breukink, B de Kruijff Biochimica et Biophysica Acta (BBA)-Biomembranes 1462 (1-2), 223-234, 1999 | 421 | 1999 |
| Identification of FtsW as a transporter of lipid‐linked cell wall precursors across the membrane T Mohammadi, V Van Dam, R Sijbrandi, T Vernet, A Zapun, A Bouhss, ... The EMBO journal 30 (8), 1425-1432, 2011 | 419 | 2011 |
| Lipid II is an intrinsic component of the pore induced by nisin in bacterial membranes E Breukink, HE van Heusden, PJ Vollmerhaus, E Swiezewska, L Brunner, ... Journal of Biological Chemistry 278 (22), 19898-19903, 2003 | 414 | 2003 |
| Antibacterial photodynamic therapy: overview of a promising approach to fight antibiotic-resistant bacterial infections Y Liu, R Qin, SAJ Zaat, E Breukink, M Heger Journal of clinical and translational research 1 (3), 140, 2015 | 411 | 2015 |
| Regulation of peptidoglycan synthesis by outer-membrane proteins A Typas, M Banzhaf, BB van Saparoea, J Verheul, J Biboy, RJ Nichols, ... Cell 143 (7), 1097-1109, 2010 | 410 | 2010 |
| Assembly and stability of nisin− lipid II pores HE Hasper, B de Kruijff, E Breukink Biochemistry 43 (36), 11567-11575, 2004 | 357 | 2004 |
| Natamycin blocks fungal growth by binding specifically to ergosterol without permeabilizing the membrane YM Te Welscher, HH Ten Napel, MM Balagué, CM Souza, H Riezman, ... Journal of Biological Chemistry 283 (10), 6393-6401, 2008 | 298 | 2008 |
| The C-terminal region of nisin is responsible for the initial interaction of nisin with the target membrane E Breukink, C van Kraaij, RA Demel, RJ Siezen, OP Kuipers, B de Kruijff Biochemistry 36 (23), 6968-6976, 1997 | 249 | 1997 |
| Functional interaction of human neutrophil peptide-1 with the cell wall precursor lipid II E de Leeuw, C Li, P Zeng, C Li, M Diepeveen-de Buin, WY Lu, E Breukink, ... FEBS letters 584 (8), 1543-1548, 2010 | 243 | 2010 |
| SecA insertion into phospholipids is stimulated by negatively charged lipids and inhibited by ATP: a monolayer study E Breukink, RA Demel, G De Korte-Kool, B De Kruijff Biochemistry 31 (4), 1119-1124, 1992 | 235 | 1992 |
| Molecular model for the solubilization of membranes into nanodisks by styrene maleic acid copolymers S Scheidelaar, MC Koorengevel, JD Pardo, JD Meeldijk, E Breukink, ... Biophysical journal 108 (2), 279-290, 2015 | 223 | 2015 |
| The C Terminus of SecA Is Involved in Both Lipid Binding and SecB Binding (∗) E Breukink, N Nouwen, A van Raalte, S Mizushima, J Tommassen, ... Journal of Biological Chemistry 270 (14), 7902-7907, 1995 | 206 | 1995 |
| Activities and regulation of peptidoglycan synthases AJF Egan, J Biboy, I van't Veer, E Breukink, W Vollmer Philosophical Transactions of the Royal Society B: Biological Sciences 370 …, 2015 | 196 | 2015 |
| Coordination of peptidoglycan synthesis and outer membrane constriction during Escherichia coli cell division AN Gray, AJF Egan, IL Van't Veer, J Verheul, A Colavin, A Koumoutsi, ... elife 4, e07118, 2015 | 191 | 2015 |
| Lipid II induces a transmembrane orientation of the pore-forming peptide lantibiotic nisin HE van Heusden, B De Kruijff, E Breukink Biochemistry 41 (40), 12171-12178, 2002 | 190 | 2002 |
