Exploring new inflammatory biomarkers and pathways during LPS‐induced M1 polarization C Cunha, C Gomes, AR Vaz, D Brites Mediators of Inflammation 2016 (1), 6986175, 2016 | 190 | 2016 |
Downregulated glia interplay and increased miRNA-155 as promising markers to track ALS at an early stage C Cunha, C Santos, C Gomes, A Fernandes, AM Correia, AM Sebastião, ... Molecular Neurobiology 55, 4207-4224, 2018 | 90 | 2018 |
Extension of retinofugal projections in an assembled model of human pluripotent stem cell-derived organoids CM Fligor, SS Lavekar, J Harkin, PK Shields, KB VanderWall, KC Huang, ... Stem Cell Reports 16 (9), 2228-2241, 2021 | 80 | 2021 |
Cortical neurotoxic astrocytes with early ALS pathology and miR-146a deficit replicate gliosis markers of symptomatic SOD1G93A mouse model C Gomes, C Cunha, F Nascimento, JA Ribeiro, AR Vaz, D Brites Molecular Neurobiology 56, 2137-2158, 2019 | 75 | 2019 |
Glycoursodeoxycholic acid reduces matrix metalloproteinase-9 and caspase-9 activation in a cellular model of superoxide dismutase-1 neurodegeneration AR Vaz, C Cunha, C Gomes, N Schmucki, M Barbosa, D Brites Molecular neurobiology 51, 864-877, 2015 | 64 | 2015 |
Recovery of depleted miR-146a in ALS cortical astrocytes reverts cell aberrancies and prevents paracrine pathogenicity on microglia and motor neurons M Barbosa, C Gomes, C Sequeira, J Gonçalves-Ribeiro, CC Pina, ... Frontiers in Cell and Developmental Biology 9, 634355, 2021 | 41 | 2021 |
Astrocyte regional diversity in ALS includes distinct aberrant phenotypes with common and causal pathological processes C Gomes, C Sequeira, M Barbosa, C Cunha, AR Vaz, D Brites Experimental Cell Research 395 (2), 112209, 2020 | 38 | 2020 |
Cross-talk between neurons and astrocytes in response to bilirubin: adverse secondary impacts AS Falcao, RFM Silva, AR Vaz, C Gomes, A Fernandes, A Barateiro, ... Neurotoxicity research 26, 1-15, 2014 | 29 | 2014 |
Neurotoxic astrocytes directly converted from sporadic and familial ALS patient fibroblasts reveal signature diversities and miR-146a theragnostic potential in specific subtypes C Gomes, C Sequeira, S Likhite, CN Dennys, SJ Kolb, PJ Shaw, AR Vaz, ... Cells 11 (7), 1186, 2022 | 26 | 2022 |
Astrocytes modulate neurodegenerative phenotypes associated with glaucoma in OPTN (E50K) human stem cell-derived retinal ganglion cells C Gomes, KB VanderWall, Y Pan, X Lu, SS Lavekar, KC Huang, ... Stem cell reports 17 (7), 1636-1649, 2022 | 24 | 2022 |
Directing mouse embryonic neurosphere differentiation toward an enriched neuronal population EF Torrado, C Gomes, G Santos, A Fernandes, D Brites, AS Falcão International Journal of Developmental Neuroscience 37, 94-99, 2014 | 16 | 2014 |
Development of a three-dimensional organoid model to explore early retinal phenotypes associated with Alzheimer’s disease SS Lavekar, J Harkin, M Hernandez, C Gomes, S Patil, KC Huang, ... Scientific Reports 13 (1), 13827, 2023 | 9 | 2023 |
A highly reproducible and efficient method for retinal organoid differentiation from human pluripotent stem cells J Harkin, KH Peña, C Gomes, M Hernandez, SS Lavekar, K So, K Lentsch, ... Proceedings of the National Academy of Sciences 121 (25), e2317285121, 2024 | 3 | 2024 |
Autophagy disruption reduces mTORC1 activation leading to retinal ganglion cell neurodegeneration associated with glaucoma KC Huang, C Gomes, Y Shiga, N Belforte, KB VanderWall, SS Lavekar, ... bioRxiv, 2023 | 3 | 2023 |
Induction of astrocyte reactivity promotes neurodegeneration in human pluripotent stem cell models C Gomes, KC Huang, J Harkin, A Baker, JM Hughes, Y Pan, K Tutrow, ... Stem Cell Reports 19 (8), 1122-1136, 2024 | 2 | 2024 |
Upregulation of miR-146a attenuates ALS mouse cortical astrocytes reactivity and decrease miRNA-inflammatory associated exosomal cargo M Barbosa, C Gomes, AR Vaz, D Brites Free Radical Biology and Medicine 120, S158, 2018 | 2 | 2018 |
Retinal ganglion cells in a dish: Current strategies and recommended best practices for effective in vitro modeling of development and disease KC Huang, C Gomes, JS Meyer Human iPSC-derived Disease Models for Drug Discovery, 83-102, 2023 | 1 | 2023 |
Acquisition of neurodegenerative features in isogenic OPTN (E50K) human stem cell-derived retinal ganglion cells associated with autophagy disruption and mTORC1 signaling reduction KC Huang, C Gomes, Y Shiga, N Belforte, KB VanderWall, SS Lavekar, ... Acta Neuropathologica Communications 12 (1), 164, 2024 | | 2024 |
Generation of novel APBB2 SNP iPSC lines to study increased risk for glaucoma unique to individuals of African ancestry AT Baker, M Hernandez, J Harkin, C Gomes, JS Meyer Investigative Ophthalmology & Visual Science 65 (7), 1545-1545, 2024 | | 2024 |
Development of a human stem cell model of Neurofibromatosis Type 1 for assessment of optic pathway phenotypes SV Patil, M Hernandez, C Gomes, JS Meyer Investigative Ophthalmology & Visual Science 65 (7), 4517-4517, 2024 | | 2024 |