| Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics A Letai, MC Bassik, LD Walensky, MD Sorcinelli, S Weiler, SJ Korsmeyer Cancer cell 2 (3), 183-192, 2002 | 2121 | 2002 |
| Activation of apoptosis in vivo by a hydrocarbon-stapled BH3 helix LD Walensky, AL Kung, I Escher, TJ Malia, S Barbuto, RD Wright, ... science 305 (5689), 1466-1470, 2004 | 1673 | 2004 |
| BAX activation is initiated at a novel interaction site E Gavathiotis, M Suzuki, ML Davis, K Pitter, GH Bird, SG Katz, HC Tu, ... Nature 455 (7216), 1076-1081, 2008 | 843 | 2008 |
| Hydrocarbon-stapled peptides: principles, practice, and progress: miniperspective LD Walensky, GH Bird Journal of medicinal chemistry 57 (15), 6275-6288, 2014 | 799 | 2014 |
| Reactivation of the p53 tumor suppressor pathway by a stapled p53 peptide F Bernal, AF Tyler, SJ Korsmeyer, LD Walensky, GL Verdine Journal of the American Chemical Society 129 (9), 2456-2457, 2007 | 679 | 2007 |
| A stapled BID BH3 helix directly binds and activates BAX LD Walensky, K Pitter, J Morash, KJ Oh, S Barbuto, J Fisher, E Smith, ... Molecular cell 24 (2), 199-210, 2006 | 498 | 2006 |
| The MCL-1 BH3 helix is an exclusive MCL-1 inhibitor and apoptosis sensitizer ML Stewart, E Fire, AE Keating, LD Walensky Nature chemical biology 6 (8), 595-601, 2010 | 490 | 2010 |
| The challenge of drugging undruggable targets in cancer: lessons learned from targeting BCL-2 family members GL Verdine, LD Walensky Clinical cancer research 13 (24), 7264-7270, 2007 | 479 | 2007 |
| Complementary genomic approaches highlight the PI3K/mTOR pathway as a common vulnerability in osteosarcoma JA Perry, A Kiezun, P Tonzi, EM Van Allen, SL Carter, SC Baca, ... Proceedings of the National Academy of Sciences 111 (51), E5564-E5573, 2014 | 438 | 2014 |
| Immunophilin FK506 binding protein associated with inositol 1, 4, 5-trisphosphate receptor modulates calcium flux. AM Cameron, JP Steiner, DM Sabatini, AI Kaplin, LD Walensky, ... Proceedings of the National Academy of Sciences 92 (5), 1784-1788, 1995 | 428 | 1995 |
| SWI/SNF-mutant cancers depend on catalytic and non-catalytic activity of EZH2 KH Kim, W Kim, TP Howard, F Vazquez, A Tsherniak, JN Wu, W Wang, ... Nature medicine 21 (12), 1491-1496, 2015 | 405 | 2015 |
| Regulation of AMPA receptor GluR1 subunit surface expression by a 4.1 N-linked actin cytoskeletal association L Shen, F Liang, LD Walensky, RL Huganir Journal of Neuroscience 20 (21), 7932-7940, 2000 | 399 | 2000 |
| Hydrocarbon double-stapling remedies the proteolytic instability of a lengthy peptide therapeutic GH Bird, N Madani, AF Perry, AM Princiotto, JG Supko, X He, ... Proceedings of the National Academy of Sciences 107 (32), 14093-14098, 2010 | 395 | 2010 |
| Targeted disruption of the EZH2–EED complex inhibits EZH2-dependent cancer W Kim, GH Bird, T Neff, G Guo, MA Kerenyi, LD Walensky, SH Orkin Nature chemical biology 9 (10), 643-650, 2013 | 377 | 2013 |
| Dual role of proapoptotic BAD in insulin secretion and beta cell survival NN Danial, LD Walensky, CY Zhang, CS Choi, JK Fisher, AJA Molina, ... Nature medicine 14 (2), 144-153, 2008 | 364 | 2008 |
| A stapled p53 helix overcomes HDMX-mediated suppression of p53 F Bernal, M Wade, M Godes, TN Davis, DG Whitehead, AL Kung, ... Cancer cell 18 (5), 411-422, 2010 | 359 | 2010 |
| BCL-2 in the crosshairs: tipping the balance of life and death LD Walensky Cell Death & Differentiation 13 (8), 1339-1350, 2006 | 351 | 2006 |
| BH3-triggered structural reorganization drives the activation of proapoptotic BAX E Gavathiotis, DE Reyna, ML Davis, GH Bird, LD Walensky Molecular cell 40 (3), 481-492, 2010 | 339 | 2010 |
| Inositol 1, 4, 5-trisphosphate receptors selectively localized to the acrosomes of mammalian sperm. LD Walensky, SH Snyder The Journal of cell biology 130 (4), 857-869, 1995 | 336 | 1995 |
| Targeted disruption of the BCL9/β-catenin complex inhibits oncogenic Wnt signaling K Takada, D Zhu, GH Bird, K Sukhdeo, JJ Zhao, M Mani, M Lemieux, ... Science translational medicine 4 (148), 148ra117-148ra117, 2012 | 270 | 2012 |
