| Protein kinases: evolution of dynamic regulatory proteins SS Taylor, AP Kornev Trends in biochemical sciences 36 (2), 65-77, 2011 | 1020 | 2011 |
| Surface comparison of active and inactive protein kinases identifies a conserved activation mechanism AP Kornev, NM Haste, SS Taylor, LF Ten Eyck Proceedings of the National Academy of Sciences 103 (47), 17783-17788, 2006 | 873 | 2006 |
| Assembly of allosteric macromolecular switches: lessons from PKA SS Taylor, R Ilouz, P Zhang, AP Kornev Nature reviews Molecular cell biology 13 (10), 646-658, 2012 | 498 | 2012 |
| A helix scaffold for the assembly of active protein kinases AP Kornev, SS Taylor, LF Ten Eyck Proceedings of the National Academy of Sciences 105 (38), 14377-14382, 2008 | 493 | 2008 |
| PKA: lessons learned after twenty years SS Taylor, P Zhang, JM Steichen, MM Keshwani, AP Kornev Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics 1834 (7), 1271-1278, 2013 | 315 | 2013 |
| Allosteric activation of functionally asymmetric RAF kinase dimers J Hu, EC Stites, H Yu, EA Germino, HS Meharena, PJS Stork, AP Kornev, ... Cell 154 (5), 1036-1046, 2013 | 312 | 2013 |
| Defining the conserved internal architecture of a protein kinase AP Kornev, SS Taylor Biochimica Et Biophysica Acta (BBA)-Proteins and Proteomics 1804 (3), 440-444, 2010 | 310 | 2010 |
| Dynamics-driven allostery in protein kinases AP Kornev, SS Taylor Trends in biochemical sciences 40 (11), 628-647, 2015 | 285 | 2015 |
| Dynamic architecture of a protein kinase CL McClendon, AP Kornev, MK Gilson, SS Taylor Proceedings of the National Academy of Sciences 111 (43), E4623-E4631, 2014 | 278 | 2014 |
| The cAMP binding domain: an ancient signaling module HM Berman, LF Ten Eyck, DS Goodsell, NM Haste, A Kornev, SS Taylor Proceedings of the National Academy of Sciences 102 (1), 45-50, 2005 | 261 | 2005 |
| Evolution of the eukaryotic protein kinases as dynamic molecular switches SS Taylor, MM Keshwani, JM Steichen, AP Kornev Philosophical Transactions of the Royal Society B: Biological Sciences 367 …, 2012 | 256 | 2012 |
| Dynamics connect substrate recognition to catalysis in protein kinase A LR Masterson, C Cheng, T Yu, M Tonelli, A Kornev, SS Taylor, G Veglia Nature chemical biology 6 (11), 821-828, 2010 | 223 | 2010 |
| Deciphering the structural basis of eukaryotic protein kinase regulation HS Meharena, P Chang, MM Keshwani, K Oruganty, AK Nene, N Kannan, ... PLoS biology 11 (10), e1001680, 2013 | 217 | 2013 |
| Structure and allostery of the PKA RIIβ tetrameric holoenzyme P Zhang, EV Smith-Nguyen, MM Keshwani, MS Deal, AP Kornev, ... Science 335 (6069), 712-716, 2012 | 184 | 2012 |
| Kinases and pseudokinases: lessons from RAF AS Shaw, AP Kornev, J Hu, LG Ahuja, SS Taylor Molecular and cellular biology 34 (9), 1538-1546, 2014 | 161 | 2014 |
| Mutation that blocks ATP binding creates a pseudokinase stabilizing the scaffolding function of kinase suppressor of Ras, CRAF and BRAF J Hu, H Yu, AP Kornev, J Zhao, EL Filbert, SS Taylor, AS Shaw Proceedings of the National Academy of Sciences 108 (15), 6067-6072, 2011 | 148 | 2011 |
| Kinase regulation by hydrophobic spine assembly in cancer J Hu, LG Ahuja, HS Meharena, N Kannan, AP Kornev, SS Taylor, ... Molecular and cellular biology 35 (1), 264-276, 2015 | 112 | 2015 |
| A dynamic hydrophobic core orchestrates allostery in protein kinases J Kim, LG Ahuja, FA Chao, Y Xia, CL McClendon, AP Kornev, SS Taylor, ... Science advances 3 (4), e1600663, 2017 | 105 | 2017 |
| Allostery through the computational microscope: cAMP activation of a canonical signalling domain RD Malmstrom, AP Kornev, SS Taylor, RE Amaro Nature communications 6 (1), 7588, 2015 | 96 | 2015 |
| The dynamic switch mechanism that leads to activation of LRRK2 is embedded in the DFGψ motif in the kinase domain SH Schmidt, MJ Knape, D Boassa, N Mumdey, AP Kornev, MH Ellisman, ... Proceedings of the National Academy of Sciences 116 (30), 14979-14988, 2019 | 76 | 2019 |
Andrey ShawSenior Staff Scientist, Genentech在 gene.com 的电子邮件经过验证
