Comparative Analysis of Mycobacterium tuberculosis pe and ppe Genes Reveals High Sequence Variation and an Apparent Absence of Selective Constraints CRE McEvoy, R Cloete, B Müller, AC Schürch, PD Van Helden, ... PloS one 7 (4), e30593, 2012 | 119 | 2012 |
Genetic variation in angiotensin-converting enzyme 2 gene is associated with extent of left ventricular hypertrophy in hypertrophic cardiomyopathy L van der Merwe, R Cloete, M Revera, M Heradien, A Goosen, ... Human genetics 124, 57-61, 2008 | 44 | 2008 |
Designing a course model for distance-based online bioinformatics training in Africa: the H3ABioNet experience KT Gurwitz, S Aron, S Panji, S Maslamoney, PL Fernandes, DP Judge, ... PLoS Computational Biology 13 (10), e1005715, 2017 | 38 | 2017 |
Analyses of HIV-1 integrase sequences prior to South African national HIV-treatment program and availability of integrase inhibitors in Cape Town, South Africa D Brado, AE Obasa, GM Ikomey, R Cloete, K Singh, S Engelbrecht, ... Scientific reports 8 (1), 4709, 2018 | 37 | 2018 |
Emerging evidence implicating a role for neurexins in neurodegenerative and neuropsychiatric disorders K Cuttler, M Hassan, J Carr, R Cloete, S Bardien Open biology 11 (10), 210091, 2021 | 35 | 2021 |
Resistance related metabolic pathways for drug target identification in Mycobacterium tuberculosis R Cloete, E Oppon, E Murungi, WD Schubert, A Christoffels Bmc Bioinformatics 17, 1-10, 2016 | 33 | 2016 |
Molecular modelling and simulation studies of the Mycobacterium tuberculosis multidrug efflux pump protein Rv1258c R Cloete, E Kapp, J Joubert, A Christoffels, SF Malan PLoS One 13 (11), e0207605, 2018 | 28 | 2018 |
Drug resistance mutations against protease, reverse transcriptase and integrase inhibitors in people living with HIV-1 receiving boosted protease inhibitors in South Africa AE Obasa, SG Mikasi, D Brado, R Cloete, K Singh, U Neogi, GB Jacobs Frontiers in microbiology 11, 438, 2020 | 26 | 2020 |
Molecular dynamic simulations to investigate the structural impact of known drug resistance mutations on HIV-1C Integrase-Dolutegravir binding R Chitongo, AE Obasa, SG Mikasi, GB Jacobs, R Cloete PLoS One 15 (5), e0223464, 2020 | 23 | 2020 |
HIV-1 integrase diversity and resistance-associated mutations and polymorphisms among integrase strand transfer inhibitor-naive HIV-1 patients from Cameroon SG Mikasi, JO Gichana, C Van der Walt, D Brado, AE Obasa, D Njenda, ... AIDS research and human retroviruses 36 (5), 450-455, 2020 | 17 | 2020 |
Structural and functional effects of nucleotide variation on the human TB drug metabolizing enzyme arylamine N-acetyltransferase 1 R Cloete, WA Akurugu, CJ Werely, PD van Helden, A Christoffels Journal of Molecular Graphics and Modelling 75, 330-339, 2017 | 16 | 2017 |
Prioritization of candidate genes for a South African family with Parkinson’s disease using in-silico tools B Sebate, K Cuttler, R Cloete, M Britz, A Christoffels, M Williams, J Carr, ... PloS one 16 (3), e0249324, 2021 | 15 | 2021 |
Aptamer-based diagnostic systems for the rapid screening of TB at the point-of-care DR Martin, NR Sibuyi, P Dube, AO Fadaka, R Cloete, M Onani, ... Diagnostics 11 (8), 1352, 2021 | 14 | 2021 |
Molecular modeling of subtype-specific Tat protein signatures to predict Tat-TAR interactions that may be involved in HIV-associated neurocognitive disorders ME Williams, R Cloete Frontiers in Microbiology 13, 866611, 2022 | 11 | 2022 |
Structural comparison of diverse Hiv-1 subtypes using molecular modelling and docking analyses of integrase inhibitors D Isaacs, SG Mikasi, AE Obasa, GM Ikomey, S Shityakov, R Cloete, ... Viruses 12 (9), 936, 2020 | 9 | 2020 |
Genome sequencing of a severe acute respiratory syndrome coronavirus 2 isolate obtained from a South African Patient with coronavirus disease 2019 M Allam, A Ismail, ZTH Khumalo, S Kwenda, P van Heusden, R Cloete, ... Microbiology Resource Announcements 9 (27), 10.1128/mra. 00572-20, 2020 | 9 | 2020 |
Interaction analysis of statistically enriched mutations identified in Cameroon recombinant subtype CRF02_AG that can influence the development of Dolutegravir drug resistance … SG Mikasi, D Isaacs, R Chitongo, GM Ikomey, GB Jacobs, R Cloete BMC infectious diseases 21 (1), 379, 2021 | 7 | 2021 |
HIV-1 drug resistance Mutation analyses of Cameroon-derived Integrase sequences SG Mikasi, D Isaacs, GM Ikomey, H Shimba, R Cloete, GB Jacobs AIDS Research and Human Retroviruses 37 (1), 54-56, 2021 | 6 | 2021 |
Structure based identification of novel inhibitors against ATP synthase of Mycobacterium tuberculosis: A combined in silico and in vitro study M Shahbaaz, R Cloete, M Grobbelaar, S Sampson, A Christoffels International journal of biological macromolecules 135, 582-590, 2019 | 6 | 2019 |
The flexible, extended coil of the PDZ-Binding motif of the three deadly human coronavirus E proteins plays a role in pathogenicity D Schoeman, R Cloete, BC Fielding Viruses 14 (8), 1707, 2022 | 5 | 2022 |