| Recon 2.2: from reconstruction to model of human metabolism N Swainston, K Smallbone, H Hefzi, PD Dobson, J Brewer, M Hanscho, ... Metabolomics 12, 1-7, 2016 | 316 | 2016 |
| A consensus genome-scale reconstruction of Chinese hamster ovary cell metabolism H Hefzi, KS Ang, M Hanscho, A Bordbar, D Ruckerbauer, M Lakshmanan, ... Cell systems 3 (5), 434-443. e8, 2016 | 245 | 2016 |
| Evolutionary and structural analyses of SARS-CoV-2 D614G spike protein mutation now documented worldwide S Isabel, L Graña-Miraglia, JM Gutierrez, C Bundalovic-Torma, HE Groves, ... Scientific reports 10 (1), 14031, 2020 | 228 | 2020 |
| Genome-scale reconstructions of the mammalian secretory pathway predict metabolic costs and limitations of protein secretion JM Gutierrez, A Feizi, S Li, TB Kallehauge, H Hefzi, LM Grav, D Ley, ... Nature communications 11 (1), 68, 2020 | 108 | 2020 |
| The emerging role of systems biology for engineering protein production in CHO cells CC Kuo, AWT Chiang, I Shamie, M Samoudi, JM Gutierrez, NE Lewis Current Opinion in Biotechnology 51, 64-69, 2018 | 105 | 2018 |
| Multiplex secretome engineering enhances recombinant protein production and purity S Kol, D Ley, T Wulff, M Decker, J Arnsdorf, S Schoffelen, AH Hansen, ... Nature communications 11 (1), 1908, 2020 | 90 | 2020 |
| Optimizing eukaryotic cell hosts for protein production through systems biotechnology and genome‐scale modeling JM Gutierrez, NE Lewis Biotechnology journal 10 (7), 939-949, 2015 | 60 | 2015 |
| Quantitative feature extraction from the Chinese hamster ovary bioprocess bibliome using a novel meta-analysis workflow A Golabgir, JM Gutierrez, H Hefzi, S Li, BO Palsson, C Herwig, NE Lewis Biotechnology advances 34 (5), 621-633, 2016 | 51 | 2016 |
| Cardiovascular events associated with chimeric antigen receptor T cell therapy: cross-sectional FDA adverse events reporting system analysis A Guha, D Addison, P Jain, JM Gutierrez, A Ghosh, C Roddie, M de Lima, ... Biology of Blood and Marrow Transplantation 26 (12), 2211-2216, 2020 | 50 | 2020 |
| Antibody optimization enabled by artificial intelligence predictions of binding affinity and naturalness S Bachas, G Rakocevic, D Spencer, AV Sastry, R Haile, JM Sutton, ... BioRxiv, 2022.08. 16.504181, 2022 | 40 | 2022 |
| Model-based assessment of mammalian cell metabolic functionalities using omics data A Richelle, BP Kellman, AT Wenzel, AWT Chiang, T Reagan, ... Cell reports methods 1 (3), 2021 | 30* | 2021 |
| Cardiovascular adverse events are associated with usage of immune checkpoint inhibitors in real-world clinical data across the United States P Jain, JG Bugarin, A Guha, C Jain, N Patil, T Shen, I Stanevich, V Nikore, ... ESMO Open 6 (5), 2021 | 30 | 2021 |
| Coordinate regulation of systemic and kidney tryptophan metabolism by the drug transporters OAT1 and OAT3 JC Granados, A Richelle, JM Gutierrez, P Zhang, X Zhang, V Bhatnagar, ... Journal of Biological Chemistry 296, 2021 | 26 | 2021 |
| Unlocking de novo antibody design with generative artificial intelligence A Shanehsazzadeh, S Bachas, M McPartlon, G Kasun, JM Sutton, ... bioRxiv, 2023.01. 08.523187, 2023 | 25 | 2023 |
| Cardiovascular adverse events associated with BRAF versus BRAF/MEK inhibitor: Cross‐sectional and longitudinal analysis using two large national registries A Guha, P Jain, MG Fradley, D Lenihan, JM Gutierrez, C Jain, M de Lima, ... Cancer medicine 10 (12), 3862-3872, 2021 | 18 | 2021 |
| Combating viral contaminants in CHO cells by engineering innate immunity AWT Chiang, S Li, BP Kellman, G Chattopadhyay, Y Zhang, CC Kuo, ... Scientific reports 9 (1), 8827, 2019 | 16 | 2019 |
| The human secretome–the proteins secreted from human cells M Uhlen, H Tegel, Å Sivertsson, CC Kuo, JM Gutierrez, NE Lewis, ... BioRxiv, 465815, 2018 | 16 | 2018 |
| Evolutionary and structural analyses of SARS-CoV-2 D614G spike protein mutation now documented worldwide. Sci Rep 10: 14031 S Isabel, L Graña-Miraglia, JM Gutierrez, C Bundalovic-Torma, HE Groves, ... | 12 | 2020 |
| Deep learning-based codon optimization with large-scale synonymous variant datasets enables generalized tunable protein expression DA Constant, JM Gutierrez, AV Sastry, R Viazzo, NR Smith, J Hossain, ... BioRxiv, 2023.02. 11.528149, 2023 | 8 | 2023 |
| Risk stratification for COVID-19 hospitalization: a multivariable model based on gradient-boosting decision trees JM Gutierrez, M Volkovs, T Poutanen, T Watson, LC Rosella Canadian Medical Association Open Access Journal 9 (4), E1223-E1231, 2021 | 6 | 2021 |
Nathan E LewisProfessor, University of California, San Diego在 ucsd.edu 的电子邮件经过验证
