| Structural basis for the autoinhibition of focal adhesion kinase D Lietha, X Cai, DFJ Ceccarelli, Y Li, MD Schaller, MJ Eck Cell 129 (6), 1177-1187, 2007 | 544 | 2007 |
| The FERM domain: organizing the structure and function of FAK MC Frame, H Patel, B Serrels, D Lietha, MJ Eck Nature reviews Molecular cell biology 11 (11), 802-814, 2010 | 427 | 2010 |
| Spatial and temporal regulation of focal adhesion kinase activity in living cells X Cai, D Lietha, DF Ceccarelli, AV Karginov, Z Rajfur, K Jacobson, ... Molecular and cellular biology, 2008 | 212 | 2008 |
| FAK structure and regulation by membrane interactions and force in focal adhesions P Tapial Martínez, P López Navajas, D Lietha Biomolecules 10 (2), 179, 2020 | 168 | 2020 |
| Phosphatidylinositol 4, 5-bisphosphate triggers activation of focal adhesion kinase by inducing clustering and conformational changes GM Goñi, C Epifano, J Boskovic, M Camacho-Artacho, J Zhou, ... Proceedings of the National Academy of Sciences 111 (31), E3177-E3186, 2014 | 152 | 2014 |
| Crystal structures of NK1–heparin complexes reveal the basis for NK1 activity and enable engineering of potent agonists of the MET receptor D Lietha, DY Chirgadze, B Mulloy, TL Blundell, E Gherardi The EMBO Journal 20 (20), 5543-5555, 2001 | 138 | 2001 |
| Structural and mechanistic insights into mechanoactivation of focal adhesion kinase MS Bauer, F Baumann, C Daday, P Redondo, E Durner, MA Jobst, ... Proceedings of the National Academy of Sciences 116 (14), 6766-6774, 2019 | 116 | 2019 |
| Crystal structures of the FAK kinase in complex with TAE226 and related bis-anilino pyrimidine inhibitors reveal a helical DFG conformation D Lietha, MJ Eck PloS one 3 (11), e3800, 2008 | 116 | 2008 |
| Tyrosine phosphorylation of Rac1: a role in regulation of cell spreading F Chang, C Lemmon, D Lietha, M Eck, L Romer PloS one 6 (12), e28587, 2011 | 89 | 2011 |
| The interactions of hepatocyte growth factor/scatter factor and its NK1 and NK2 variants with glycosaminoglycans using a modified gel mobility shift assay: elucidation of the … M Lyon, JA Deakin, D Lietha, E Gherardi, JT Gallagher Journal of Biological Chemistry 279 (42), 43560-43567, 2004 | 67 | 2004 |
| Synthesis of novel diarylamino-1, 3, 5-triazine derivatives as FAK inhibitors with anti-angiogenic activity P Dao, R Jarray, J Le Coq, D Lietha, A Loukaci, Y Lepelletier, ... Bioorganic & medicinal chemistry letters 23 (16), 4552-4556, 2013 | 62 | 2013 |
| Design, Synthesis, and Evaluation of Novel Imidazo[1,2-a][1,3,5]triazines and Their Derivatives as Focal Adhesion Kinase Inhibitors with Antitumor Activity P Dao, N Smith, C Tomkiewicz-Raulet, E Yen-Pon, M Camacho-Artacho, ... Journal of medicinal chemistry 58 (1), 237-251, 2015 | 58 | 2015 |
| Structural basis of Focal Adhesion Kinase activation on lipid membranes I Acebrón, RD Righetto, C Schoenherr, S de Buhr, P Redondo, J Culley, ... The EMBO journal 39 (19), e104743, 2020 | 54 | 2020 |
| Allosteric regulation of focal adhesion kinase by PIP2 and ATP J Zhou, A Bronowska, J Le Coq, D Lietha, F Gräter Biophysical journal 108 (3), 698-705, 2015 | 54 | 2015 |
| ORP2 couples LDL‐cholesterol transport to FAK activation by endosomal cholesterol/PI(4,5)P2 exchange K Takahashi, K Kanerva, L Vanharanta, L Almeida‐Souza, D Lietha, ... The EMBO Journal 40 (14), e106871, 2021 | 44 | 2021 |
| Exome sequencing of plasma DNA portrays the mutation landscape of colorectal cancer and discovers mutated VEGFR2 receptors as modulators of antiangiogenic therapies RA Toledo, E Garralda, M Mitsi, T Pons, J Monsech, E Vega, Á Otero, ... Clinical Cancer Research 24 (15), 3550-3559, 2018 | 44 | 2018 |
| A tethered ligand assay to probe SARS-CoV-2: ACE2 interactions MS Bauer, S Gruber, A Hausch, PSFC Gomes, LF Milles, T Nicolaus, ... Proceedings of the National Academy of Sciences 119 (14), e2114397119, 2022 | 43 | 2022 |
| Synthesis of novel 1, 2, 4-triazine scaffold as FAK inhibitors with antitumor activity P Dao, D Lietha, M Etheve-Quelquejeu, C Garbay, H Chen Bioorganic & Medicinal Chemistry Letters 27 (8), 1727-1730, 2017 | 41 | 2017 |
| Roles of membrane domains in integrin-mediated cell adhesion D Lietha, T Izard International Journal of Molecular Sciences 21 (15), 5531, 2020 | 40 | 2020 |
| Structural basis for interdomain communication in SHIP2 providing high phosphatase activity J Le Coq, M Camacho-Artacho, JV Velazquez, CM Santiveri, LH Gallego, ... Elife 6, e26640, 2017 | 38 | 2017 |
