The p97 inhibitor CB-5083 is a unique disrupter of protein homeostasis in models of multiple myeloma R Le Moigne, BT Aftab, S Djakovic, E Dhimolea, E Valle, M Murnane, ... Molecular cancer therapeutics 16 (11), 2375-2386, 2017 | 115 | 2017 |
The hexosamine biosynthetic pathway and cancer: Current knowledge and future therapeutic strategies C Lam, JY Low, PT Tran, H Wang Cancer letters 503, 11-18, 2021 | 68 | 2021 |
Proteasome inhibitor-induced modulation reveals the spliceosome as a specific therapeutic vulnerability in multiple myeloma HH Huang, ID Ferguson, AM Thornton, P Bastola, C Lam, YHT Lin, ... Nature communications 11 (1), 1931, 2020 | 47 | 2020 |
Repurposing tofacitinib as an anti-myeloma therapeutic to reverse growth-promoting effects of the bone marrow microenvironment C Lam, ID Ferguson, MC Mariano, YHT Lin, M Murnane, H Liu, GA Smith, ... Haematologica 103 (7), 1218, 2018 | 37 | 2018 |
Allosteric HSP70 inhibitors perturb mitochondrial proteostasis and overcome proteasome inhibitor resistance in multiple myeloma ID Ferguson, YHT Lin, C Lam, H Shao, KM Tharp, M Hale, C Kasap, ... Cell chemical biology 29 (8), 1288-1302. e7, 2022 | 15 | 2022 |
Bittersweet tumor development and progression: Emerging roles of epithelial plasticity glycosylations RM Phillips, C Lam, H Wang, PT Tran Advances in cancer research 142, 23-62, 2019 | 11 | 2019 |
Griseofulvin Radiosensitizes Non–Small Cell Lung Cancer Cells and Activates cGAS X Wang, N Raman, G Lemtiri-Chlieh, J Chang, S Jagtap, DD Chowdhury, ... Molecular cancer therapeutics 22 (4), 519-528, 2023 | 4 | 2023 |
Allosteric HSP70 inhibitors perturb mitochondrial proteostasis and overcome proteasome inhibitor resistance in multiple myeloma ID Ferguson, YHT Lin, C Lam, H Shao, M Hale, KM Tharp, MC Mariano, ... bioRxiv, 2020.04. 21.052456, 2020 | 2 | 2020 |
Novel allosteric inhibitors of heat shock protein 70 as agents to probe protein homeostasis and overcome proteasome inhibitor resistance in multiple myeloma I Ferguson, C Lam, MC Mariano, D Wang, P Phojanakong, S Toumivaara, ... Blood 132, 3212, 2018 | 2 | 2018 |
Hijacking myeloma metabolism to target cytotoxic chemotherapy to malignant plasma cells with decreased bone marrow toxicity H Liu, C Lam, B Jandeleit, WN Fischer, B Hann, KJ Koller, AP Wiita | 1 | 2017 |
TWIST1-induced suppression of oncogene-induced senescence in non-small cell lung cancer requires the transactivation domain of TWIST1 AM Lafargue, H Wang, ST Chettiar, RP Gajula, AC Shetty, Y Song, ... Cancer Research 84 (6_Supplement), 2968-2968, 2024 | | 2024 |
Modeling Twist1 overexpression in a pancreatic ductal adenocarcinoma mouse model MA Khan, J Chang, T Nguyen, DN Council, DD Chowdhury, A Shetty, ... Cancer Research 84 (6_Supplement), 1444-1444, 2024 | | 2024 |
Real-World Safety and Health Care Resource Utilization Analysis of Venetoclax and Hypomethylating-Agent Treatment for AML in an Academic-Affiliated Urban Community Oncology Network SG Carlson, J Boiarsky, CE Daniel, D Gaut, C Cascavita, C Lam, M Doyel, ... Blood 140 (Supplement 1), 13282-13284, 2022 | | 2022 |
P-100: Allosteric HSP70 inhibitors perturb mitochondrial proteostasis and overcome proteasome inhibitor resistance in multiple myeloma I Ferguson, T Lin, C Lam, H Shao, K Tharp, B Van Ness, J Gestwicki, ... Clinical Lymphoma Myeloma and Leukemia 22, S90, 2022 | | 2022 |
Integrated Transcriptomic and Proteomic Analysis Reveals Role of the Hexosamine Biosynthetic Pathway in Invasion and Metastasis of Hepatocellular Carcinoma C Lam Johns Hopkins University, 2021 | | 2021 |
Abstract PO-030: The harmala alkaloid harmine as a novel cancer cell radiosensitizer CRP Smack, A Lafargue, C Lam, FA Carrieri, I Siddiqui, H Wang, PT Tran Clinical Cancer Research 27 (8_Supplement), PO-030-PO-030, 2021 | | 2021 |
Abstract PO-067: The transactivation domain of TWIST1 is required for TWIST1-induced aggressiveness in non-small cell lung cancer A Lafargue, H Wang, ST Chettiar, RP Gajula, C Smack, I Siddiqui, ... Clinical Cancer Research 27 (8_Supplement), PO-067-PO-067, 2021 | | 2021 |
Integrated Transcriptomic and Proteomic Analyses Reveal Role of the Hexosamine Biosynthetic Pathway in Invasion and Metastasis of Hepatocellular Carcinoma C Lam, MA Barbhuiya, M Considine, E Henriet, H Wang, FA Carrieri, ... International Journal of Radiation Oncology, Biology, Physics 108 (3), S49-S50, 2020 | | 2020 |
Establishment of patient-derived organoids as ex vivo tool to characterize the molecular mechanisms of SCLC chemo-radiation resistance FA Carrieri, N Connis, EM Grasset, IS Chan, E Luidy-Imada, C Lam, ... Cancer Research 80 (16_Supplement), 3926-3926, 2020 | | 2020 |
Allosteric HSP70 inhibitors overcome proteasome inhibitor resistance by perturbing mitochondrial proteostasis I Ferguson, C Lam, S Toumivaara, M Mariano, P Phojanakong, D Wang, ... MOLECULAR & CELLULAR PROTEOMICS 18 (8), S63-S63, 2019 | | 2019 |