| The exosome contains domains with specific endoribonuclease, exoribonuclease and cytoplasmic mRNA decay activities D Schaeffer, B Tsanova, A Barbas, FP Reis, EG Dastidar, ... Nature structural & molecular biology 16 (1), 56-62, 2009 | 355 | 2009 |
| Unravelling the dynamics of RNA degradation by ribonuclease II and its RNA-bound complex C Frazão, CE McVey, M Amblar, A Barbas, C Vonrhein, CM Arraiano, ... Nature 443 (7107), 110-114, 2006 | 256 | 2006 |
| Challenges in antibody development against Tn and Sialyl-Tn antigens LR Loureiro, MA Carrascal, A Barbas, JS Ramalho, C Novo, P Delannoy, ... Biomolecules 5 (3), 1783-1809, 2015 | 108 | 2015 |
| Characterization of the functional domains of Escherichia coli RNase II M Amblar, A Barbas, AM Fialho, CM Arraiano Journal of molecular biology 360 (5), 921-933, 2006 | 85 | 2006 |
| New insights into the mechanism of RNA degradation by ribonuclease II: identification of the residue responsible for setting the RNase II end product A Barbas, RG Matos, M Amblar, E Lopez-Vinas, P Gomez-Puertas, ... Journal of Biological Chemistry 283 (19), 13070-13076, 2008 | 64 | 2008 |
| The role of the S1 domain in exoribonucleolytic activity: substrate specificity and multimerization M Amblar, A Barbas, P Gomez-Puertas, CM Arraiano Rna 13 (3), 317-327, 2007 | 61 | 2007 |
| RNase R mutants elucidate the catalysis of structured RNA: RNA-binding domains select the RNAs targeted for degradation RG Matos, A Barbas, CM Arraiano Biochemical Journal 423 (2), 291-301, 2009 | 59 | 2009 |
| Notch-out for breast cancer therapies M Lamy, A Ferreira, JS Dias, S Braga, G Silva, A Barbas New biotechnology 39, 215-221, 2017 | 58 | 2017 |
| Novel monoclonal antibody L2A5 specifically targeting sialyl-Tn and short glycans terminated by alpha-2–6 sialic acids LR Loureiro, DP Sousa, D Ferreira, W Chai, L Lima, C Pereira, CB Lopes, ... Scientific reports 8 (1), 12196, 2018 | 54 | 2018 |
| A single mutation in Escherichia coli ribonuclease II inactivates the enzyme without affecting RNA binding M Amblar, CM Arraiano The FEBS journal 272 (2), 363-374, 2005 | 51 | 2005 |
| Determination of key residues for catalysis and RNA cleavage specificity: one mutation turns RNase II into a “SUPER-ENZYME” A Barbas, RG Matos, M Amblar, E Lopez-Vinas, P Gomez-Puertas, ... Journal of Biological Chemistry 284 (31), 20486-20498, 2009 | 44 | 2009 |
| Swapping the domains of exoribonucleases RNase II and RNase R: conferring upon RNase II the ability to degrade ds RNA RG Matos, A Barbas, P Gómez‐Puertas, CM Arraiano Proteins: Structure, Function, and Bioinformatics 79 (6), 1853-1867, 2011 | 35 | 2011 |
| Biochemical Characterization of the RNase II Family of Exoribonucleases from the Human Pathogens Salmonella typhimurium and Streptococcus pneumoniae S Domingues, RG Matos, FP Reis, AM Fialho, A Barbas, CM Arraiano Biochemistry 48 (50), 11848-11857, 2009 | 30 | 2009 |
| Antigenic response to CT‐P13 and infliximab originator in inflammatory bowel disease patients shows similar epitope recognition J Goncalves, M Santos, R Acurcio, I Iria, L Gouveia, P Matos Brito, ... Alimentary pharmacology & therapeutics 48 (5), 507-522, 2018 | 29 | 2018 |
| RNase II: The finer details of the Modus operandi of a molecular killer CM Arraiano, RG Matos, A Barbas RNA biology 7 (3), 276-281, 2010 | 27 | 2010 |
| The Notch ligand DLL1 exerts carcinogenic features in human breast cancer cells J Sales-Dias, G Silva, M Lamy, A Ferreira, A Barbas PloS one 14 (5), e0217002, 2019 | 26 | 2019 |
| Characterizing ribonucleases in vitro: examples of synergies between biochemical and structural analysis CM Arraiano, A Barbas, M Amblar Methods in enzymology 447, 131-160, 2008 | 20 | 2008 |
| Comparison of EMSA and SPR for the characterization of RNA–RNase II complexes RG Matos, A Barbas, CM Arraiano The Protein Journal 29, 394-397, 2010 | 19 | 2010 |
| Evaluation of AAV-mediated delivery of shRNA to target basal-like breast cancer genetic vulnerabilities C Pinto, G Silva, AS Ribeiro, M Oliveira, M Garrido, VS Bandeira, ... Journal of biotechnology 300, 70-77, 2019 | 18 | 2019 |
| Modulating the RNA processing and decay by the exosome: altering Rrp44/Dis3 activity and end-product FP Reis, A Barbas, AA Klauer-King, B Tsanova, D Schaeffer, ... PloS one 8 (11), e76504, 2013 | 16 | 2013 |
Paulino Gomez-PuertasCientífico Titular CSIC. Centro de Biología Molecular "Severo Ochoa".在 cbm.csic.es 的电子邮件经过验证
