The ribosomal stalk binds to translation factors IF2, EF-Tu, EF-G and RF3 via a conserved region of the L12 C-terminal domain M Helgstrand, CS Mandava, FAA Mulder, A Liljas, S Sanyal, M Akke Journal of molecular biology 365 (2), 468-479, 2007 | 145 | 2007 |
Structural and functional insights into the mode of action of a universally conserved Obg GTPase B Feng, CS Mandava, Q Guo, J Wang, W Cao, N Li, Y Zhang, Y Zhang, ... PLoS biology 12 (5), e1001866, 2014 | 139 | 2014 |
HflX is a ribosome-splitting factor rescuing stalled ribosomes under stress conditions Y Zhang, CS Mandava, W Cao, X Li, D Zhang, N Li, Y Zhang, X Zhang, ... Nature structural & molecular biology 22 (11), 906-913, 2015 | 102 | 2015 |
A single-step method for purification of active His-tagged ribosomes from a genetically engineered Escherichia coli J Ederth, CS Mandava, S Dasgupta, S Sanyal Nucleic acids research 37 (2), e15-e15, 2009 | 93 | 2009 |
The ribosomal stalk plays a key role in IF2-mediated association of the ribosomal subunits C Huang, CS Mandava, S Sanyal Journal of Molecular Biology 399 (1), 145-153, 2010 | 59 | 2010 |
Bacterial ribosome requires multiple L12 dimers for efficient initiation and elongation of protein synthesis involving IF2 and EF-G CS Mandava, K Peisker, J Ederth, R Kumar, X Ge, W Szaflarski, S Sanyal Nucleic Acids Research 40 (5), 2054-2064, 2012 | 49 | 2012 |
Repurposing tRNAs for nonsense suppression S Albers, B Beckert, MC Matthies, CS Mandava, R Schuster, C Seuring, ... Nature Communications 12 (1), 3850, 2021 | 42 | 2021 |
Cryo-EM shows stages of initial codon selection on the ribosome by aa-tRNA in ternary complex with GTP and the GTPase-deficient EF-TuH84A M Fislage, J Zhang, ZP Brown, CS Mandava, S Sanyal, M Ehrenberg, ... Nucleic Acids Research 46 (11), 5861-5874, 2018 | 41 | 2018 |
Ribosomes lacking protein S20 are defective in mRNA binding and subunit association C Tobin, CS Mandava, M Ehrenberg, DI Andersson, S Sanyal Journal of molecular biology 397 (3), 767-776, 2010 | 37 | 2010 |
Structure and function of FusB: an elongation factor G-binding fusidic acid resistance protein active in ribosomal translocation and recycling X Guo, K Peisker, K Bäckbro, Y Chen, RK Koripella, CS Mandava, ... Open biology 2 (3), 120016, 2012 | 34 | 2012 |
A conserved histidine in switch-II of EF-G moderates release of inorganic phosphate RK Koripella, M Holm, D Dourado, CS Mandava, S Flores, S Sanyal Scientific reports 5 (1), 12970, 2015 | 33 | 2015 |
Loss of a single methylation in 23S rRNA delays 50S assembly at multiple late stages and impairs translation initiation and elongation W Wang, W Li, X Ge, K Yan, CS Mandava, S Sanyal, N Gao Proceedings of the National Academy of Sciences 117 (27), 15609-15619, 2020 | 32 | 2020 |
Micrococcin P1–A bactericidal thiopeptide active against Mycobacterium tuberculosis G Degiacomi, Y Personne, G Mondésert, X Ge, CS Mandava, ... Tuberculosis 100, 95-101, 2016 | 31 | 2016 |
Regulation of PfEMP1–VAR2CSA translation by a Plasmodium translation-enhancing factor S Chan, A Frasch, CS Mandava, JH Ch'Ng, MP Quintana, M Vesterlund, ... Nature microbiology 2 (7), 1-11, 2017 | 27 | 2017 |
Complementary charge-based interaction between the ribosomal-stalk protein L7/12 and IF2 is the key to rapid subunit association X Ge, CS Mandava, C Lind, J Åqvist, S Sanyal Proceedings of the National Academy of Sciences 115 (18), 4649-4654, 2018 | 23 | 2018 |
The mechanism of error induction by the antibiotic viomycin provides insight into the fidelity mechanism of translation M Holm, CS Mandava, M Ehrenberg, S Sanyal Elife 8, e46124, 2019 | 13 | 2019 |
Mechanistic insights into translation inhibition by aminoglycoside antibiotic arbekacin NP Parajuli, CS Mandava, MY Pavlov, S Sanyal Nucleic Acids Research 49 (12), 6880-6892, 2021 | 11 | 2021 |
Insights into translocation mechanism and ribosome evolution from cryo-EM structures of translocation intermediates of Giardia intestinalis S Majumdar, A Emmerich, S Krakovka, CS Mandava, SG Svärd, S Sanyal Nucleic acids research 51 (7), 3436-3451, 2023 | 7 | 2023 |
Optimization of a fluorescent-mRNA based real-time assay for precise kinetic measurements of ribosomal translocation C Kim, M Holm, CS Mandava, S Sanyal RNA biology 18 (12), 2363-2375, 2021 | 5 | 2021 |
Lamotrigine compromises the fidelity of initiator tRNA recruitment to the ribosomal P-site by IF2 and the RbfA release from 30S ribosomes in Escherichia coli S Singh, K Lahry, CS Mandava, J Singh, RA Shah, S Sanyal, U Varshney RNA biology 20 (1), 681-692, 2023 | 3 | 2023 |