| β-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE R Vassar, BD Bennett, S Babu-Khan, S Kahn, EA Mendiaz, P Denis, ... Science 286 (5440), 735, 1999 | 5246 | 1999 |
| Secreted amyloid β–protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to … D Scheuner, C Eckman, M Jensen, X Song, M Citron, N Suzuki, TD Bird, ... Nature medicine 2 (8), 864-870, 1996 | 3581 | 1996 |
| Mutation of the β-amyloid precursor protein in familial Alzheimer's disease increases β-protein production M Citron, T Oltersdorf, C Haass, L McConlogue, AY Hung, P Seubert, ... Nature 360 (6405), 672-674, 1992 | 2612 | 1992 |
| Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid β-protein in both transfected cells and transgenic mice M Citron, D Westaway, W Xia, G Carlson, T Diehl, G Levesque, ... Nature medicine 3 (1), 67-72, 1997 | 1857 | 1997 |
| Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation Y Luo, B Bolon, S Kahn, BD Bennett, S Babu-Khan, P Denis, W Fan, ... Nature neuroscience 4 (3), 2001-03, 2001 | 1432 | 2001 |
| Alzheimer's disease: strategies for disease modification M Citron Nature reviews Drug discovery 9 (5), 387-398, 2010 | 1354 | 2010 |
| Control of peripheral nerve myelination by the ß-secretase BACE1 M Willem, AN Garratt, B Novak, M Citron, S Kaufmann, A Rittger, ... Science 314 (5799), 664, 2006 | 919 | 2006 |
| α-Synuclein fibrillogenesis is nucleation-dependent SJ Wood, J Wypych, S Steavenson, JC Louis, M Citron, AL Biere Journal of Biological Chemistry 274 (28), 19509, 1999 | 906 | 1999 |
| Elevated β-secretase expression and enzymatic activity detected in sporadic Alzheimer disease LB Yang, K Lindholm, R Yan, M Citron, W Xia, XL Yang, T Beach, L Sue, ... Nature medicine 9 (1), 3-4, 2003 | 903 | 2003 |
| Both familial Parkinson’s disease mutations accelerate α-synuclein aggregation L Narhi, SJ Wood, S Steavenson, Y Jiang, GM Wu, D Anafi, SA Kaufman, ... Journal of Biological Chemistry 274 (14), 9843, 1999 | 902 | 1999 |
| The Swedish mutation causes early-onset Alzheimer's disease by β-secretase cleavage within the secretory pathway C Haass, CA Lemere, A Capell, M Citron, P Seubert, D Schenk, L Lannfelt, ... Nature medicine 1 (12), 1291-1296, 1995 | 828 | 1995 |
| BACE1 deficiency rescues memory deficits and cholinergic dysfunction in a mouse model of Alzheimer's disease M Ohno, EA Sametsky, LH Younkin, H Oakley, SG Younkin, M Citron, ... Neuron 41 (1), 27-33, 2004 | 688 | 2004 |
| Strategies for disease modification in Alzheimer's disease M Citron Nature Reviews Neuroscience 5 (9), 677-685, 2004 | 680 | 2004 |
| Anti-inflammatory drug therapy alters β-amyloid processing and deposition in an animal model of Alzheimer's disease Q Yan, J Zhang, H Liu, S Babu-Khan, R Vassar, AL Biere, M Citron, ... Journal of Neuroscience 23 (20), 7504-7509, 2003 | 662 | 2003 |
| Amyloid β peptide load is correlated with increased β-secretase activity in sporadic Alzheimer's disease patients R Li, K Lindholm, LB Yang, X Yue, M Citron, R Yan, T Beach, L Sue, ... Proceedings of the National Academy of Sciences of the United States of …, 2004 | 656 | 2004 |
| Activation of protein kinase C inhibits cellular production of the amyloid beta-protein. AY Hung, C Haass, RM Nitsch, WQ Qiu, M Citron, RJ Wurtman, ... Journal of Biological Chemistry 268 (31), 22959-22962, 1993 | 514 | 1993 |
| Excessive production of amyloid beta-protein by peripheral cells of symptomatic and presymptomatic patients carrying the Swedish familial Alzheimer disease mutation M Citron, C Vigo-Pelfrey, DB Teplow, C Miller, D Schenk, J Johnston, ... Proceedings of the National Academy of Sciences 91 (25), 11993, 1994 | 503 | 1994 |
| The proteolytic fragments of the Alzheimer’s disease-associated presenilin-1 form heterodimers and occur as a 100–150-kDa molecular mass complex A Capell, J Grünberg, B Pesold, A Diehlmann, M Citron, R Nixon, ... Journal of Biological Chemistry 273 (6), 3205, 1998 | 451 | 1998 |
| Robust Central Reduction of Amyloid-β in Humans with an Orally Available, Non-Peptidic β-Secretase Inhibitor PC May, RA Dean, SL Lowe, F Martenyi, SM Sheehan, LN Boggs, ... The Journal of Neuroscience 31 (46), 16507-16516, 2011 | 443 | 2011 |
| Expression analysis of BACE2 in brain and peripheral tissues BD Bennett, S Babu-Khan, R Loeloff, JC Louis, E Curran, M Citron, ... Journal of Biological Chemistry 275 (27), 20647-20651, 2000 | 441 | 2000 |
