An essential role for nuclear receptors SXR/PXR in detoxification of cholestatic bile acids W Xie, A Radominska-Pandya, Y Shi, CM Simon, MC Nelson, ES Ong, ... Proceedings of the National Academy of Sciences 98 (6), 3375-3380, 2001 | 921 | 2001 |
Structural and functional studies of UDP-glucuronosyltransferases A Radominska-Pandya, PJ Czernik, JM Little, E Battaglia, PI Mackenzie Drug metabolism reviews 31 (4), 817-899, 1999 | 622 | 1999 |
Control of steroid, heme, and carcinogen metabolism by nuclear pregnane X receptor and constitutive androstane receptor W Xie, MF Yeuh, A Radominska-Pandya, SPS Saini, Y Negishi, ... Proceedings of the National Academy of Sciences 100 (7), 4150-4155, 2003 | 426 | 2003 |
Distinct pharmacology and metabolism of K2 synthetic cannabinoids compared to Δ9-THC: mechanism underlying greater toxicity? WE Fantegrossi, JH Moran, A Radominska-Pandya, PL Prather Life sciences 97 (1), 45-54, 2014 | 302 | 2014 |
Crystal structure of the cofactor-binding domain of the human phase II drug-metabolism enzyme UDP-glucuronosyltransferase 2B7 MJ Miley, AK Zielinska, JE Keenan, SM Bratton, A Radominska-Pandya, ... Journal of molecular biology 369 (2), 498-511, 2007 | 233 | 2007 |
Studies on the substrate specificity of human intestinal UDP-glucuronosyltransferases 1A8 and 1A10 Z Cheng, A Radominska-Pandya, TR Tephly Drug Metabolism and Disposition 27 (10), 1165-1170, 1999 | 227 | 1999 |
Cytochrome P450-mediated oxidative metabolism of abused synthetic cannabinoids found in K2/Spice: identification of novel cannabinoid receptor ligands KC Chimalakonda, KA Seely, SM Bratton, LK Brents, CL Moran, ... Drug metabolism and disposition 40 (11), 2174-2184, 2012 | 223 | 2012 |
Quantitative measurement of JWH-018 and JWH-073 metabolites excreted in human urine CL Moran, VH Le, KC Chimalakonda, AL Smedley, FD Lackey, SN Owen, ... Analytical chemistry 83 (11), 4228-4236, 2011 | 211 | 2011 |
Human PXR variants and their differential effects on the regulation of human UDP-glucuronosyltransferase gene expression D Gardner-Stephen, JM Heydel, A Goyal, Y Lu, W Xie, T Lindblom, ... Drug Metabolism and Disposition 32 (3), 340-347, 2004 | 207 | 2004 |
Monohydroxylated metabolites of the K2 synthetic cannabinoid JWH-073 retain intermediate to high cannabinoid 1 receptor (CB1R) affinity and exhibit neutral antagonist to … LK Brents, A Gallus-Zawada, A Radominska-Pandya, T Vasiljevik, ... Biochemical pharmacology 83 (7), 952-961, 2012 | 204 | 2012 |
Differential glucuronidation of bile acids, androgens and estrogens by human UGT1A3 and 2B7 WE Gall, G Zawada, B Mojarrabi, TR Tephly, MD Green, BL Coffman, ... The Journal of steroid biochemistry and molecular biology 70 (1-3), 101-108, 1999 | 179 | 1999 |
Characterization of human hepatic and extrahepatic UDP-glucuronosyltransferase enzymes involved in the metabolism of classic cannabinoids A Mazur, CF Lichti, PL Prather, AK Zielinska, SM Bratton, ... Drug Metabolism and Disposition 37 (7), 1496-1504, 2009 | 172 | 2009 |
Regulation of UDP glucuronosyltransferase genes PI MacKenzie, PA Gregory, DA Gardner-Stephen, RH Lewinsky, ... Current drug metabolism 4 (3), 249-257, 2003 | 163 | 2003 |
Cloning and expression of human UDP-glucuronosyltransferase (UGT) 1A8 Z Cheng, A Radominska-Pandya, TR Tephly Archives of Biochemistry and Biophysics 356 (2), 301-305, 1998 | 156 | 1998 |
UDP-glucuronosyltransferases in human intestinal mucosa A Radominska-Pandya, JM Little, JT Pandya, TR Tephly, CD King, ... Biochimica et Biophysica Acta (BBA)-Lipids and Lipid Metabolism 1394 (2-3 …, 1998 | 147 | 1998 |
4-hydroxyretinoic acid, a novel substrate for human liver microsomal UDP-glucuronosyltransferase (s) and recombinant UGT2B7 VM Samokyszyn, WE Gall, G Zawada, MA Freyaldenhoven, G Chen, ... Journal of Biological Chemistry 275 (10), 6908-6914, 2000 | 144 | 2000 |
Glucuronidation of 2-hydroxyamino-1-methyl-6-phenylimidazo [4, 5-b] pyridine by human microsomal UDP-glucuronosyltransferases: identification of specific UGT1A family isoforms … SA Nowell, JS Massengill, S Williams, A Radominska-Pandya, TR Tephly, ... Carcinogenesis 20 (6), 1107-1114, 1999 | 139 | 1999 |
Orphan nuclear receptor-mediated xenobiotic regulation in drug metabolism W Xie, H Uppal, SPS Saini, Y Mu, JM Little, A Radominska-Pandya, ... Drug discovery today 9 (10), 442-449, 2004 | 138 | 2004 |
Direct interaction of all-trans-retinoic acid with protein kinase C (PKC): implications for PKC signaling and cancer therapy A Radominska-Pandya, G Chen, PJ Czernik, JM Little, VM Samokyszyn, ... Journal of Biological Chemistry 275 (29), 22324-22330, 2000 | 136 | 2000 |
K2 toxicity: fatal case of psychiatric complications following AM2201 exposure AL Patton, KC Chimalakonda, CL Moran, KR McCain, ... Journal of forensic sciences 58 (6), 1676-1680, 2013 | 129 | 2013 |