| PD-1 alters T-cell metabolic reprogramming by inhibiting glycolysis and promoting lipolysis and fatty acid oxidation N Patsoukis, K Bardhan, P Chatterjee, D Sari, B Liu, LN Bell, ED Karoly, ... Nature communications 6 (1), 6692, 2015 | 1101 | 2015 |
| Inhibiting glycolytic metabolism enhances CD8+ T cell memory and antitumor function M Sukumar, J Liu, Y Ji, M Subramanian, JG Crompton, Z Yu, ... The Journal of clinical investigation 123 (10), 4479-4488, 2013 | 939 | 2013 |
| Profiling the effects of isocitrate dehydrogenase 1 and 2 mutations on the cellular metabolome ZJ Reitman, G Jin, ED Karoly, I Spasojevic, J Yang, KW Kinzler, Y He, ... Proceedings of the National Academy of Sciences 108 (8), 3270-3275, 2011 | 489 | 2011 |
| MYC-driven accumulation of 2-hydroxyglutarate is associated with breast cancer prognosis A Terunuma, N Putluri, P Mishra, EA Mathé, TH Dorsey, M Yi, TA Wallace, ... The Journal of clinical investigation 124 (1), 398-412, 2014 | 426 | 2014 |
| Genetic predisposition to an impaired metabolism of the branched-chain amino acids and risk of type 2 diabetes: a Mendelian randomisation analysis LA Lotta, RA Scott, SJ Sharp, S Burgess, J Luan, T Tillin, AF Schmidt, ... PLoS medicine 13 (11), e1002179, 2016 | 421 | 2016 |
| Integrated metabolite and gene expression profiles identify lipid biomarkers associated with progression of hepatocellular carcinoma and patient outcomes A Budhu, S Roessler, X Zhao, Z Yu, M Forgues, J Ji, E Karoly, LX Qin, ... Gastroenterology 144 (5), 1066-1075. e1, 2013 | 240 | 2013 |
| Senescent human fibroblasts show increased glycolysis and redox homeostasis with extracellular metabolomes that overlap with those of irreparable DNA damage, aging, and disease EL James, RD Michalek, GN Pitiyage, AM De Castro, KS Vignola, J Jones, ... Journal of proteome research 14 (4), 1854-1871, 2015 | 235 | 2015 |
| Uremic solutes and risk of end-stage renal disease in type 2 diabetes: metabolomic study MA Niewczas, TL Sirich, AV Mathew, J Skupien, RP Mohney, JH Warram, ... Kidney international 85 (5), 1214-1224, 2014 | 230 | 2014 |
| A gradient of glycolytic activity coordinates FGF and Wnt signaling during elongation of the body axis in amniote embryos M Oginuma, P Moncuquet, F Xiong, E Karoly, J Chal, K Guevorkian, ... Developmental cell 40 (4), 342-353. e10, 2017 | 186 | 2017 |
| Ozone exposure increases circulating stress hormones and lipid metabolites in humans DB Miller, AJ Ghio, ED Karoly, LN Bell, SJ Snow, MC Madden, J Soukup, ... American journal of respiratory and critical care medicine 193 (12), 1382-1391, 2016 | 181 | 2016 |
| Landscape of the mitochondrial Hsp90 metabolome in tumours YC Chae, A Angelin, S Lisanti, AV Kossenkov, KD Speicher, H Wang, ... Nature communications 4 (1), 2139, 2013 | 175 | 2013 |
| Metabolomic analysis of prostate cancer risk in a prospective cohort: The alpha‐tocopherol, beta‐carotene cancer prevention (ATBC) study AM Mondul, SC Moore, SJ Weinstein, ED Karoly, JN Sampson, D Albanes International journal of cancer 137 (9), 2124-2132, 2015 | 165 | 2015 |
| Oncogene-induced senescence results in marked metabolic and bioenergetic alterations C Quijano, L Cao, MM Fergusson, H Romero, J Liu, S Gutkind, II Rovira, ... Cell Cycle 11 (7), 1383-1392, 2012 | 156 | 2012 |
| High-fat diet fuels prostate cancer progression by rewiring the metabolome and amplifying the MYC program DP Labbé, G Zadra, M Yang, JM Reyes, CY Lin, S Cacciatore, EM Ebot, ... Nature communications 10 (1), 4358, 2019 | 153 | 2019 |
| Inhaled ozone (O3)-induces changes in serum metabolomic and liver transcriptomic profiles in rats DB Miller, ED Karoly, JC Jones, WO Ward, BD Vallanat, DL Andrews, ... Toxicology and applied pharmacology 286 (2), 65-79, 2015 | 117 | 2015 |
| Metabolic alterations in lung cancer–associated fibroblasts correlated with increased glycolytic metabolism of the tumor VK Chaudhri, GG Salzler, SA Dick, MS Buckman, R Sordella, ED Karoly, ... Molecular Cancer Research 11 (6), 579-592, 2013 | 117 | 2013 |
| 1, 5-Anhydroglucitol in saliva is a noninvasive marker of short-term glycemic control DO Mook-Kanamori, MMED Selim, AH Takiddin, H Al-Homsi, ... The Journal of Clinical Endocrinology & Metabolism 99 (3), E479-E483, 2014 | 112 | 2014 |
| In vitro sulfoxidation of thioether compounds by human cytochrome P450 and flavin-containing monooxygenase isoforms with particular reference to the CYP2C subfamily KA Usmani, ED Karoly, E Hodgson, RL Rose Drug metabolism and disposition 32 (3), 333-339, 2004 | 108 | 2004 |
| A systems view of type 2 diabetes-associated metabolic perturbations in saliva, blood and urine at different timescales of glycaemic control NA Yousri, DO Mook-Kanamori, MMED Selim, AH Takiddin, H Al-Homsi, ... Diabetologia 58, 1855-1867, 2015 | 103 | 2015 |
| The role of particulate matter-associated zinc in cardiac injury in rats UP Kodavanti, MC Schladweiler, PS Gilmour, JG Wallenborn, ... Environmental health perspectives 116 (1), 13-20, 2008 | 93 | 2008 |
