A review of protein-small molecule docking methods RD Taylor, PJ Jewsbury, JW Essex Journal of computer-aided molecular design 16, 151-166, 2002 | 1013 | 2002 |
Structure-based design of a potent purine-based cyclin-dependent kinase inhibitor TG Davies, J Bentley, CE Arris, FT Boyle, NJ Curtin, JA Endicott, ... Nature structural biology 9 (10), 745-749, 2002 | 282 | 2002 |
Identification of novel purine and pyrimidine cyclin-dependent kinase inhibitors with distinct molecular interactions and tumor cell growth inhibition profiles CE Arris, FT Boyle, AH Calvert, NJ Curtin, JA Endicott, EF Garman, ... Journal of medicinal chemistry 43 (15), 2797-2804, 2000 | 271 | 2000 |
Discovery of 4-{4-[(3R)-3-Methylmorpholin-4-yl]-6-[1-(methylsulfonyl)cyclopropyl]pyrimidin-2-yl}-1H-indole (AZ20): A Potent and Selective Inhibitor of ATR Protein … KM Foote, K Blades, A Cronin, S Fillery, SS Guichard, L Hassall, I Hickson, ... Journal of medicinal chemistry 56 (5), 2125-2138, 2013 | 248 | 2013 |
Discovery and characterization of AZD6738, a potent inhibitor of ataxia telangiectasia mutated and Rad3 related (ATR) kinase with application as an anticancer agent KM Foote, JWM Nissink, T McGuire, P Turner, S Guichard, JWT Yates, ... Journal of medicinal chemistry 61 (22), 9889-9907, 2018 | 237 | 2018 |
Aurora kinase inhibitor nanoparticles target tumors with favorable therapeutic index in vivo S Ashton, YH Song, J Nolan, E Cadogan, J Murray, R Odedra, J Foster, ... Science translational medicine 8 (325), 325ra17-325ra17, 2016 | 223 | 2016 |
N2-substituted O 6-cyclohexylmethylguanine derivatives: potent inhibitors of cyclin-dependent kinases 1 and 2 IR Hardcastle, CE Arris, J Bentley, FT Boyle, Y Chen, NJ Curtin, ... Journal of medicinal chemistry 47 (15), 3710-3722, 2004 | 153 | 2004 |
Imidazo [1, 2-a] pyridines: a potent and selective class of cyclin-dependent kinase inhibitors identified through structure-based hybridisation M Anderson, JF Beattie, GA Breault, J Breed, KF Byth, JD Culshaw, ... Bioorganic & Medicinal Chemistry Letters 13 (18), 3021-3026, 2003 | 151 | 2003 |
FDS: flexible ligand and receptor docking with a continuum solvent model and soft‐core energy function RD Taylor, PJ Jewsbury, JW Essex Journal of computational chemistry 24 (13), 1637-1656, 2003 | 126 | 2003 |
Cyclin-dependent kinase 4 inhibitors as a treatment for cancer. Part 1: identification and optimisation of substituted 4, 6-bis anilino pyrimidines JF Beattie, GA Breault, RPA Ellston, S Green, PJ Jewsbury, CJ Midgley, ... Bioorganic & medicinal chemistry letters 13 (18), 2955-2960, 2003 | 111 | 2003 |
Probing the ATP ribose-binding domain of cyclin-dependent kinases 1 and 2 with O 6-substituted guanine derivatives AE Gibson, CE Arris, J Bentley, FT Boyle, NJ Curtin, TG Davies, ... Journal of medicinal chemistry 45 (16), 3381-3393, 2002 | 109 | 2002 |
Structure-based design of 2-arylamino-4-cyclohexylmethyl-5-nitroso-6-aminopyrimidine inhibitors of cyclin-dependent kinases 1 and 2 KL Sayle, J Bentley, FT Boyle, AH Calvert, Y Cheng, NJ Curtin, ... Bioorganic & medicinal chemistry letters 13 (18), 3079-3082, 2003 | 92 | 2003 |
The proximal residue largely determines the CO distortion in carbon monoxy globin proteins. An ab initio study of a heme prosthetic unit P Jewsbury, S Yamamoto, T Minato, M Saito, T Kitagawa The Journal of Physical Chemistry 99 (33), 12677-12685, 1995 | 83 | 1995 |
Novel, potent and selective anilinoquinazoline and anilinopyrimidine inhibitors of p38 MAP kinase JG Cumming, CL McKenzie, SG Bowden, D Campbell, DJ Masters, ... Bioorganic & medicinal chemistry letters 14 (21), 5389-5394, 2004 | 75 | 2004 |
4-Alkoxy-2, 6-diaminopyrimidine derivatives: inhibitors of cyclin dependent kinases 1 and 2 V Mesguiche, RJ Parsons, CE Arris, J Bentley, FT Boyle, NJ Curtin, ... Bioorganic & medicinal chemistry letters 13 (2), 217-222, 2003 | 72 | 2003 |
The distal residue-CO interaction in carbonmonoxy myoglobins: a molecular dynamics study of two distal histidine tautomers P Jewsbury, T Kitagawa Biophysical journal 67 (6), 2236-2250, 1994 | 65 | 1994 |
Einstein A-coefficients and transition dipole moments for some ion-pair to valence transitions in I2 K Lawley, P Jewsbury, T Ridley, P Langridge-Smith, R Donovan Molecular Physics 75 (4), 811-828, 1992 | 65 | 1992 |
Cyclin-dependent kinase 4 inhibitors as a treatment for cancer. Part 2: identification and optimisation of substituted 2, 4-bis anilino pyrimidines GA Breault, RPA Ellston, S Green, SR James, PJ Jewsbury, CJ Midgley, ... Bioorganic & medicinal chemistry letters 13 (18), 2961-2966, 2003 | 64 | 2003 |
REPLACE: a strategy for iterative design of cyclin‐binding groove inhibitors MJI Andrews, G Kontopidis, C McInnes, A Plater, L Innes, A Cowan, ... ChemBioChem 7 (12), 1909-1915, 2006 | 63 | 2006 |
A novel systemically administered toll‐like receptor 7 agonist potentiates the effect of ionizing radiation in murine solid tumor models AL Adlard, SJ Dovedi, BA Telfer, E Koga‐Yamakawa, C Pollard, ... International journal of cancer 135 (4), 820-829, 2014 | 55 | 2014 |