| The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs YI Zhu, T Tchkonia, T Pirtskhalava, AC Gower, H Ding, N Giorgadze, ... Aging cell 14 (4), 644-658, 2015 | 2076 | 2015 |
| Senolytics improve physical function and increase lifespan in old age M Xu, T Pirtskhalava, JN Farr, BM Weigand, AK Palmer, MM Weivoda, ... Nature medicine 24 (8), 1246-1256, 2018 | 1767 | 2018 |
| Cellular senescence drives age-dependent hepatic steatosis M Ogrodnik, S Miwa, T Tchkonia, D Tiniakos, CL Wilson, A Lahat, CP Day, ... Nature communications 8 (1), 15691, 2017 | 812 | 2017 |
| Chronic senolytic treatment alleviates established vasomotor dysfunction in aged or atherosclerotic mice CM Roos, B Zhang, AK Palmer, MB Ogrodnik, T Pirtskhalava, NM Thalji, ... Aging cell 15 (5), 973-977, 2016 | 696 | 2016 |
| Targeting senescent cells enhances adipogenesis and metabolic function in old age M Xu, AK Palmer, H Ding, MM Weivoda, T Pirtskhalava, TA White, A Sepe, ... elife 4, e12997, 2015 | 542 | 2015 |
| Targeting senescent cells alleviates obesity‐induced metabolic dysfunction AK Palmer, M Xu, YI Zhu, T Pirtskhalava, MM Weivoda, CM Hachfeld, ... Aging cell 18 (3), e12950, 2019 | 479 | 2019 |
| Obesity-induced cellular senescence drives anxiety and impairs neurogenesis M Ogrodnik, YI Zhu, LGP Langhi, T Tchkonia, P Krüger, E Fielder, ... Cell metabolism 29 (5), 1061-1077. e8, 2019 | 435 | 2019 |
| Cellular senescence in type 2 diabetes: a therapeutic opportunity AK Palmer, T Tchkonia, NK LeBrasseur, EN Chini, M Xu, JL Kirkland Diabetes 64 (7), 2289-2298, 2015 | 419 | 2015 |
| Exercise prevents diet-induced cellular senescence in adipose tissue MJ Schafer, TA White, G Evans, JM Tonne, GC Verzosa, MB Stout, ... Diabetes 65 (6), 1606-1615, 2016 | 322 | 2016 |
| Aging and adipose tissue: potential interventions for diabetes and regenerative medicine AK Palmer, JL Kirkland Experimental gerontology 86, 97-105, 2016 | 317 | 2016 |
| Cellular senescence: at the nexus between ageing and diabetes AK Palmer, B Gustafson, JL Kirkland, U Smith Diabetologia 62, 1835-1841, 2019 | 243 | 2019 |
| Growth hormone action predicts age-related white adipose tissue dysfunction and senescent cell burden in mice MB Stout, T Tchkonia, T Pirtskhalava, AK Palmer, EO List, DE Berryman, ... Aging (Albany NY) 6 (7), 575, 2014 | 121 | 2014 |
| 17α-Estradiol alleviates age-related metabolic and inflammatory dysfunction in male mice without inducing feminization MB Stout, FJ Steyn, MJ Jurczak, JPG Camporez, YI Zhu, JR Hawse, ... Journals of Gerontology Series A: Biomedical Sciences and Medical Sciences …, 2017 | 112 | 2017 |
| Targeting p21Cip1 highly expressing cells in adipose tissue alleviates insulin resistance in obesity L Wang, B Wang, NS Gasek, Y Zhou, RL Cohn, DE Martin, W Zuo, ... Cell metabolism 34 (1), 75-89. e8, 2022 | 108 | 2022 |
| New horizons: novel approaches to enhance healthspan through targeting cellular senescence and related aging mechanisms T Tchkonia, AK Palmer, JL Kirkland The Journal of Clinical Endocrinology & Metabolism 106 (3), e1481-e1487, 2021 | 85 | 2021 |
| Metabolic changes in aging humans: current evidence and therapeutic strategies AK Palmer, MD Jensen The Journal of clinical investigation 132 (16), 2022 | 76 | 2022 |
| Senescence marker activin A is increased in human diabetic kidney disease: association with kidney function and potential implications for therapy X Bian, TP Griffin, X Zhu, MN Islam, SM Conley, A Eirin, H Tang, ... BMJ Open Diabetes Research and Care 7 (1), e000720, 2019 | 46 | 2019 |
| Orally-active, clinically-translatable senolytics restore α-Klotho in mice and humans Y Zhu, LGPL Prata, EOW Gerdes, JME Netto, T Pirtskhalava, N Giorgadze, ... EBioMedicine 77, 2022 | 39 | 2022 |
| Senolytics: potential for alleviating diabetes and its complications AK Palmer, T Tchkonia, JL Kirkland Endocrinology 162 (8), bqab058, 2021 | 28 | 2021 |
| Killing senescent cells and treating senescence-associated conditions using a src inhibitor and a flavonoid JL Kirkland, T Tchkonia, Y Zhu, AK Palmer, NK LeBrasseur, JD Miller US Patent App. 15/113,723, 2017 | 26 | 2017 |
