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Bartholomew P. Roland
Bartholomew P. Roland
Septerna Inc.
在 septerna.com 的电子邮件经过验证
标题
引用次数
引用次数
年份
Genetically engineered mesenchymal stem cells reduce behavioral deficits in the YAC 128 mouse model of Huntington's disease
ND Dey, MC Bombard, BP Roland, S Davidson, M Lu, J Rossignol, ...
Behavioural brain research 214 (2), 193-200, 2010
1862010
Inhibiting the nucleation of amyloid structure in a huntingtin fragment by targeting α-helix-rich oligomeric intermediates
R Mishra, M Jayaraman, BP Roland, E Landrum, T Fullam, R Kodali, ...
Journal of molecular biology 415 (5), 900-917, 2012
932012
Yeast and human P4-ATPases transport glycosphingolipids using conserved structural motifs
BP Roland, T Naito, JT Best, C Arnaiz-Yépez, H Takatsu, JY Roger, ...
Journal of Biological Chemistry 294 (6), 1794-1806, 2019
642019
Mechanisms of endothelial cell dysfunction in cystic fibrosis
L Totani, R Plebani, A Piccoli, S Di Silvestre, P Lanuti, A Recchiuti, ...
Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1863 (12 …, 2017
612017
A tutorial for pharmacogenomics implementation through end‐to‐end clinical decision support based on ten years of experience from PREDICT
M Liu, CL Vnencak‐Jones, BP Roland, CL Gatto, JL Mathe, SL Just, ...
Clinical Pharmacology & Therapeutics 109 (1), 101-115, 2021
452021
Decoding P4-ATPase substrate interactions
BP Roland, TR Graham
Critical reviews in biochemistry and molecular biology 51 (6), 513-527, 2016
402016
Adaptive substitutions underlying cardiac glycoside insensitivity in insects exhibit epistasis in vivo
AM Taverner, L Yang, ZJ Barile, B Lin, J Peng, AP Pinharanda, AS Rao, ...
Elife 8, e48224, 2019
392019
Triosephosphate isomerase I170V alters catalytic site, enhances stability and induces pathology in a Drosophila model of TPI deficiency
BP Roland, CG Amrich, CJ Kammerer, KA Stuchul, SB Larsen, S Rode, ...
Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1852 (1), 61-69, 2015
382015
Evidence of a triosephosphate isomerase non-catalytic function crucial to behavior and longevity
BP Roland, KA Stuchul, SB Larsen, CG Amrich, AP VanDemark, ...
Journal of Cell Science 126 (14), 3151-3158, 2013
372013
Structural and genetic studies demonstrate neurologic dysfunction in triosephosphate isomerase deficiency is associated with impaired synaptic vesicle dynamics
BP Roland, AM Zeccola, SB Larsen, CG Amrich, AD Talsma, KA Stuchul, ...
PLoS Genetics 12 (3), e1005941, 2016
322016
Directed evolution of a sphingomyelin flippase reveals mechanism of substrate backbone discrimination by a P4-ATPase
BP Roland, TR Graham
Proceedings of the National Academy of Sciences 113 (31), E4460-E4466, 2016
262016
A serendipitous survey of prediction algorithms for amyloidogenicity
BP Roland, R Kodali, R Mishra, R Wetzel
Peptide Science 100 (6), 780-789, 2013
232013
Missense variant in TPI1 (Arg189Gln) causes neurologic deficits through structural changes in the triosephosphate isomerase catalytic site and reduced enzyme levels in vivo
BP Roland, KR Richards, SL Hrizo, S Eicher, ZJ Barile, TC Chang, ...
Biochimica Et Biophysica Acta (BBA)-Molecular Basis of Disease 1865 (9 …, 2019
182019
Exofacial membrane composition and lipid metabolism regulates plasma membrane P4-ATPase substrate specificity
BK Jain, BP Roland, TR Graham
Journal of Biological Chemistry 295 (52), 17997-18009, 2020
82020
Impact of updating pharmacogenetic results: lessons learned from the PREDICT program
M Liu, SL Van Driest, CL Vnencak-Jones, LAG Saucier, BP Roland, ...
Journal of Personalized Medicine 11 (11), 1051, 2021
62021
Predatory fireflies and their toxic firefly prey have evolved distinct toxin resistance strategies
L Yang, F Borne, A Betz, ML Aardema, Y Zhen, J Peng, R Visconti, M Wu, ...
Current Biology 33 (23), 5160-5168. e7, 2023
5*2023
Intrastriatal transplantation of bone marrow stem cells that are genetically engineered to overexpress brain-derived neurotrophic factor reduces behavioral deficits in the …
MC Bombard, ND Dey, BP Roland, M Lu, J Matchynski, S Lowrance, ...
CELL TRANSPLANTATION 17 (4), 462-462, 2008
32008
The novel neuroimmunophillin, GPI 1485, attenuates age-related cognitive deficits in rats
ND Dey, MC Bombard, RA Myers, AJ Boersen, BP Roland, MI Sandstrom, ...
CELL TRANSPLANTATION 16 (3), 319-320, 2007
32007
Exofacial membrane composition and lipid metabolism regulates plasma membrane P4-ATPase substrate specificity
BP Roland, BK Jain, TR Graham
bioRxiv, 2020.06. 24.169672, 2020
22020
A Tutorial for Pharmacogenomics Implementation Through End-to-End Clinical Decision Support Based on Ten Years of Experience From PREDICT (vol 109, pg 101, 2021)
M Liu, CL Vnencak-Jones, BP Roland, CL Gatto, JL Mathe, SL Just, ...
CLINICAL PHARMACOLOGY & THERAPEUTICS 112 (5), 1130-1130, 2022
2022
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