Structural evidence for regulation and specificity of flaviviral proteases and evolution of the Flaviviridae fold AE Aleshin, SA Shiryaev, AY Strongin, RC Liddington Protein science 16 (5), 795-806, 2007 | 253 | 2007 |
Epitope-resolved profiling of the SARS-CoV-2 antibody response identifies cross-reactivity with endemic human coronaviruses JT Ladner, SN Henson, AS Boyle, AL Engelbrektson, ZW Fink, F Rahee, ... Cell Reports Medicine 2 (1), 2021 | 189 | 2021 |
Substrate cleavage analysis of furin and related proprotein convertases: a comparative study AG Remacle, SA Shiryaev, ES Oh, P Cieplak, A Srinivasan, G Wei, ... Journal of Biological Chemistry 283 (30), 20897-20906, 2008 | 162 | 2008 |
Emetine inhibits Zika and Ebola virus infections through two molecular mechanisms: inhibiting viral replication and decreasing viral entry S Yang, M Xu, EM Lee, K Gorshkov, SA Shiryaev, S He, W Sun, ... Cell discovery 4 (1), 31, 2018 | 151 | 2018 |
Novel MT1-MMP small-molecule inhibitors based on insights into hemopexin domain function in tumor growth AG Remacle, VS Golubkov, SA Shiryaev, R Dahl, JL Stebbins, ... Cancer research 72 (9), 2339-2349, 2012 | 146 | 2012 |
The MMP-9/TIMP-1 axis controls the status of differentiation and function of myelin-forming Schwann cells in nerve regeneration Y Kim, AG Remacle, AV Chernov, H Liu, I Shubayev, C Lai, J Dolkas, ... PloS one 7 (3), e33664, 2012 | 142 | 2012 |
Repurposing of the anti-malaria drug chloroquine for Zika Virus treatment and prophylaxis SA Shiryaev, P Mesci, A Pinto, I Fernandes, N Sheets, S Shresta, C Farhy, ... Scientific reports 7 (1), 15771, 2017 | 141 | 2017 |
Simultaneous visualization of protumorigenic Src and MT1-MMP activities with fluorescence resonance energy transfer M Ouyang, H Huang, NC Shaner, AG Remacle, SA Shiryaev, AY Strongin, ... Cancer research 70 (6), 2204-2212, 2010 | 135 | 2010 |
Tissue inhibitor of metalloproteinases-2 binding to membrane-type 1 matrix metalloproteinase induces MAPK activation and cell growth by a non-proteolytic mechanism S D'Alessio, G Ferrari, K Cinnante, W Scheerer, AC Galloway, DF Roses, ... Journal of Biological Chemistry 283 (1), 87-99, 2008 | 133 | 2008 |
Targeting host cell furin proprotein convertases as a therapeutic strategy against bacterial toxins and viral pathogens SA Shiryaev, AG Remacle, BI Ratnikov, NA Nelson, AY Savinov, G Wei, ... Journal of Biological Chemistry 282 (29), 20847-20853, 2007 | 127 | 2007 |
Matrix metalloproteinase proteolysis of the myelin basic protein isoforms is a source of immunogenic peptides in autoimmune multiple sclerosis SA Shiryaev, AY Savinov, P Cieplak, BI Ratnikov, K Motamedchaboki, ... PloS one 4 (3), e4952, 2009 | 123 | 2009 |
NS4A regulates the ATPase activity of the NS3 helicase: a novel cofactor role of the non-structural protein NS4A from West Nile virus SA Shiryaev, AV Chernov, AE Aleshin, TN Shiryaeva, AY Strongin Journal of General Virology 90 (9), 2081-2085, 2009 | 122 | 2009 |
Characterization of the Zika virus two-component NS2B-NS3 protease and structure-assisted identification of allosteric small-molecule antagonists SA Shiryaev, C Farhy, A Pinto, CT Huang, N Simonetti, AE Ngono, ... Antiviral research 143, 218-229, 2017 | 120 | 2017 |
HTS identifies novel and specific uncompetitive inhibitors of the two-component NS2B-NS3 proteinase of West Nile virus PA Johnston, J Phillips, TY Shun, S Shinde, JS Lazo, DM Huryn, ... Assay and drug development technologies 5 (6), 737-750, 2007 | 117 | 2007 |
Cleavage targets and the D-arginine-based inhibitors of the West Nile virus NS3 processing proteinase SA Shiryaev, BI Ratnikov, AV Chekanov, S Sikora, DV Rozanov, A Godzik, ... Biochemical Journal 393 (2), 503-511, 2006 | 107 | 2006 |
Cleavage preference distinguishes the two-component NS2B–NS3 serine proteinases of Dengue and West Nile viruses SA Shiryaev, IA Kozlov, BI Ratnikov, JW Smith, M Lebl, AY Strongin Biochemical Journal 401 (3), 743-752, 2007 | 91 | 2007 |
Zika virus protease cleavage of host protein septin-2 mediates mitotic defects in neural progenitors H Li, L Saucedo-Cuevas, L Yuan, D Ross, A Johansen, D Sands, ... Neuron 101 (6), 1089-1098. e4, 2019 | 81 | 2019 |
Zika virus: origins, pathological action, and treatment strategies K Gorshkov, SA Shiryaev, S Fertel, YW Lin, CT Huang, A Pinto, C Farhy, ... Frontiers in microbiology 9, 3252, 2019 | 76 | 2019 |
Blocking Zika virus vertical transmission P Mesci, A Macia, SM Moore, SA Shiryaev, A Pinto, CT Huang, L Tejwani, ... Scientific reports 8 (1), 1218, 2018 | 76 | 2018 |
Structure–activity relationship and improved hydrolytic stability of pyrazole derivatives that are allosteric inhibitors of West Nile Virus NS2B-NS3 proteinase S Sidique, SA Shiryaev, BI Ratnikov, A Herath, Y Su, AY Strongin, ... Bioorganic & medicinal chemistry letters 19 (19), 5773-5777, 2009 | 74 | 2009 |