关注
Douglas A. Hansen
Douglas A. Hansen
Totus Medicines
在 umich.edu 的电子邮件经过验证
标题
引用次数
引用次数
年份
Structure of a modular polyketide synthase
S Dutta, JR Whicher, DA Hansen, WA Hale, JA Chemler, GR Congdon, ...
Nature 510 (7506), 512-517, 2014
3782014
Structural rearrangements of a polyketide synthase module during its catalytic cycle
JR Whicher, S Dutta, DA Hansen, WA Hale, JA Chemler, AM Dosey, ...
Nature 510 (7506), 560-564, 2014
2232014
Evolution of a highly active and enantiospecific metalloenzyme from short peptides
S Studer, DA Hansen, ZL Pianowski, PRE Mittl, A Debon, SL Guffy, ...
Science 362 (6420), 1285-1288, 2018
1382018
Cyanobacterial polyketide synthase docking domains: a tool for engineering natural product biosynthesis
JR Whicher, SS Smaga, DA Hansen, WC Brown, WH Gerwick, ...
Chemistry & biology 20 (11), 1340-1351, 2013
1232013
Nonribosomal biosynthesis of backbone-modified peptides
DL Niquille, DA Hansen, T Mori, D Fercher, H Kries, D Hilvert
Nature chemistry 10 (3), 282-287, 2018
1122018
Inversion of extender unit selectivity in the erythromycin polyketide synthase by acyltransferase domain engineering
I Koryakina, C Kasey, JB McArthur, AN Lowell, JA Chemler, S Li, ...
ACS chemical biology 12 (1), 114-123, 2017
792017
Directing group-controlled regioselectivity in an enzymatic C–H bond oxygenation
S Negretti, ARH Narayan, KC Chiou, PM Kells, JL Stachowski, ...
Journal of the American Chemical Society 136 (13), 4901-4904, 2014
782014
Biocatalytic synthesis of pikromycin, methymycin, neomethymycin, novamethymycin, and ketomethymycin
DA Hansen, CM Rath, EB Eisman, ARH Narayan, JD Kittendorf, ...
Journal of the American Chemical Society 135 (30), 11232-11238, 2013
762013
Evolution of efficient modular polyketide synthases by homologous recombination
JA Chemler, A Tripathi, DA Hansen, M O’Neil-Johnson, RB Williams, ...
Journal of the American Chemical Society 137 (33), 10603-10609, 2015
502015
A single active site mutation in the pikromycin thioesterase generates a more effective macrocyclization catalyst
AA Koch, DA Hansen, VV Shende, LR Furan, KN Houk, G Jiménez-Osés, ...
Journal of the American Chemical Society 139 (38), 13456-13465, 2017
472017
Resistance to ketolide antibiotics by coordinated expression of rRNA methyltransferases in a bacterial producer of natural ketolides
MM Almutairi, SR Park, S Rose, DA Hansen, N Vázquez-Laslop, ...
Proceedings of the National Academy of Sciences 112 (42), 12956-12961, 2015
352015
Co-produced natural ketolides methymycin and pikromycin inhibit bacterial growth by preventing synthesis of a limited number of proteins
MM Almutairi, MS Svetlov, DA Hansen, NF Khabibullina, D Klepacki, ...
Nucleic acids research 45 (16), 9573-9582, 2017
332017
Identification of a thioesterase bottleneck in the pikromycin pathway through full-module processing of unnatural pentaketides
DA Hansen, AA Koch, DH Sherman
Journal of the American Chemical Society 139 (38), 13450-13455, 2017
302017
Substrate controlled divergence in polyketide synthase catalysis
DA Hansen, AA Koch, DH Sherman
Journal of the American Chemical Society 137 (11), 3735-3738, 2015
282015
Biocatalytic synthesis of α-amino ketones
SW Chun, ARH Narayan
Synlett 30 (11), 1269-1274, 2019
212019
Triple molecular target approach to selective melanoma cytotoxicity
EB Skibo, A Jamil, B Austin, D Hansen, A Ghodousi
Organic & Biomolecular Chemistry 8 (7), 1577-1587, 2010
152010
Probing selectivity and creating structural diversity through hybrid polyketide synthases
AA Koch, JJ Schmidt, AN Lowell, DA Hansen, KM Coburn, JA Chemler, ...
Angewandte Chemie 132 (32), 13677-13682, 2020
132020
Reprogramming nonribosomal peptide synthesis by surgical mutation
DL Niquille, DA Hansen, D Hilvert
Synlett 30 (19), 2123-2130, 2019
92019
High-throughput reprogramming of an NRPS condensation domain
IB Folger, NF Frota, A Pistofidis, DL Niquille, DA Hansen, TM Schmeing, ...
Nature Chemical Biology, 1-9, 2024
52024
ENGINEERING POLYKETIDE MOLECULAR GLUES
B Pang, E Crull, P Hawkins, J Wong, D Hansen, R Estrela, H Roth, ...
4th International Conference on Natural Product Discovery and Development in …, 2023
2023
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