| Discovery of 1-(4-Methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro- 1H-pyrazolo[3,4-c]pyridine-3-carboxamide (Apixaban, BMS-562247 … DJP Pinto, MJ Orwat, S Koch, KA Rossi, RS Alexander, A Smallwood, ... Journal of medicinal chemistry 50 (22), 5339-5356, 2007 | 516 | 2007 |
| Discovery of 1-[3-(Aminomethyl)phenyl]-N-[3-fluoro-2‘-(methylsulfonyl)- [1,1‘-biphenyl]-4-yl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide (DPC423), a Highly … DJP Pinto, MJ Orwat, S Wang, JM Fevig, ML Quan, E Amparo, J Cacciola, ... Journal of medicinal chemistry 44 (4), 566-578, 2001 | 261 | 2001 |
| Nitrogen containing heteroaromatics as factor Xa inhibitors DJP Pinto, JR Pruitt, J Cacciola, JM Fevig, Q Han, MJ Orwat, ML Quan, ... US Patent 6,020,357, 2000 | 237 | 2000 |
| Synthesis and Biological Evaluation of 1-Aryl-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-4-one Inhibitors of Cyclin-Dependent Kinases JA Markwalder, MR Arnone, PA Benfield, M Boisclair, CR Burton, ... Journal of medicinal chemistry 47 (24), 5894-5911, 2004 | 149 | 2004 |
| Structure-based design of novel guanidine/benzamidine mimics: potent and orally bioavailable factor Xa inhibitors as novel anticoagulants PYS Lam, CG Clark, R Li, DJP Pinto, MJ Orwat, RA Galemmo, JM Fevig, ... Journal of medicinal chemistry 46 (21), 4405-4418, 2003 | 120 | 2003 |
| Nitrogen containing heteroaromatics with ortho-substituted P1's as factor Xa inhibitors RA Galemmo Jr, LL Bostrom, DJP Pinto, KA Rossi US Patent 6,548,525, 2003 | 114 | 2003 |
| Five-membered heterocycles useful as serine protease inhibitors JJ Hangeland, ML Quan, JM Smallheer, GS Bisacchi, JR Corte, ... US Patent 7,453,002, 2008 | 110 | 2008 |
| Synthesis and evaluation of indenopyrazoles as cyclin-dependent kinase inhibitors. 2. Probing the indeno ring substituent pattern DA Nugiel, A Vidwans, AM Etzkorn, KA Rossi, PA Benfield, CR Burton, ... Journal of medicinal chemistry 45 (24), 5224-5232, 2002 | 100 | 2002 |
| Discovery of 1-(2-Aminomethylphenyl)-3-trifluoromethyl-N- [3-fluoro-2‘-(aminosulfonyl)[1,1‘-biphenyl)]-4-yl]-1H-pyrazole-5-carboxyamide (DPC602), a Potent … JR Pruitt, DJP Pinto, RA Galemmo, RS Alexander, KA Rossi, BL Wells, ... Journal of medicinal chemistry 46 (25), 5298-5315, 2003 | 93 | 2003 |
| Tetrahydroquinoline derivatives as potent and selective factor XIa inhibitors ML Quan, PC Wong, C Wang, F Woerner, JM Smallheer, FA Barbera, ... Journal of Medicinal Chemistry 57 (3), 955-969, 2014 | 79 | 2014 |
| 5-Amidinobenzo [b] thiophenes as dual inhibitors of factors IXa and Xa JX Qiao, X Cheng, DP Modi, KA Rossi, JM Luettgen, RM Knabb, ... Bioorganic & medicinal chemistry letters 15 (1), 29-35, 2005 | 78 | 2005 |
| Preparation of 1-(4-methoxyphenyl)-1H-pyrazolo [4, 3-d] pyrimidin-7 (6H)-ones as potent, selective and bioavailable inhibitors of coagulation factor Xa JM Fevig, J Cacciola, J Buriak Jr, KA Rossi, RM Knabb, JM Luettgen, ... Bioorganic & medicinal chemistry letters 16 (14), 3755-3760, 2006 | 69 | 2006 |
| 1-[3-Aminobenzisoxazol-5′-yl]-3-trifluoromethyl-6-[2′-(3-(R)-hydroxy-N-pyrrolidinyl) methyl-[1, 1′]-biphen-4-yl]-1, 4, 5, 6-tetrahydropyrazolo-[3, 4-c]-pyridin-7-one (BMS … DJP Pinto, MJ Orwat, ML Quan, Q Han, RA Galemmo Jr, E Amparo, ... Bioorganic & medicinal chemistry letters 16 (15), 4141-4147, 2006 | 62 | 2006 |
| Benzimidazolinones, benzoxazolinones, benzopiperazinones, indanones, and derivatives thereof as inhibitors of factor Xa Q Han, C Dominguez, EC Amparo, JM Park, ML Quan, KA Rossi US Patent 6,207,697, 2001 | 56 | 2001 |
| Discovery of 5-Chloro-4-((1-(5-chloropyrimidin-2-yl)piperidin-4-yl)oxy)-1-(2-fluoro-4-(methylsulfonyl)phenyl)pyridin-2(1H)-one (BMS-903452), an Antidiabetic … DA Wacker, Y Wang, M Broekema, K Rossi, S O’Connor, Z Hong, G Wu, ... Journal of Medicinal Chemistry 57 (18), 7499-7508, 2014 | 54 | 2014 |
| Discovery of a parenteral small molecule coagulation factor XIa inhibitor clinical candidate (BMS-962212) DJP Pinto, MJ Orwat, LM Smith, ML Quan, PYS Lam, KA Rossi, A Apedo, ... Journal of Medicinal Chemistry 60 (23), 9703-9723, 2017 | 53 | 2017 |
| Design, synthesis, and biological evaluation of potent and selective amidino bicyclic factor Xa inhibitors Q Han, C Dominguez, PFW Stouten, JM Park, DE Duffy, RA Galemmo, ... Journal of medicinal chemistry 43 (23), 4398-4415, 2000 | 53 | 2000 |
| Discovery of milvexian, a high-affinity, orally bioavailable inhibitor of factor XIa in clinical studies for antithrombotic therapy AK Dilger, KB Pabbisetty, JR Corte, I De Lucca, T Fang, W Yang, ... Journal of medicinal chemistry 65 (3), 1770-1785, 2021 | 50 | 2021 |
| Factor XIa inhibitors as new anticoagulants ML Quan, DJP Pinto, JM Smallheer, WR Ewing, KA Rossi, JM Luettgen, ... Journal of Medicinal Chemistry 61 (17), 7425-7447, 2018 | 50 | 2018 |
| Nitrogen containing heteroaromatics as factor Xa inhibitors DJP Pinto, JR Pruitt, J Cacciola, JM Fevig, Q Han, MJ Orwat, ML Quan, ... US Patent 6,548,512, 2003 | 50 | 2003 |
