| Structural basis of a phototropin light switch SM Harper, LC Neil, KH Gardner Science 301 (5639), 1541-1544, 2003 | 929 | 2003 |
| THE USE OF 2H, 13C, 15N MULTIDIMENSIONAL NMR GTO STUDY THE STRUCTURE AND DYNAMICS OF PROTEINS KH Gardner, LE Kay Annual review of biophysics and biomolecular structure 27 (1), 357-406, 1998 | 810 | 1998 |
| Targeting renal cell carcinoma with a HIF-2 antagonist W Chen, H Hill, A Christie, MS Kim, E Holloman, A Pavia-Jimenez, ... Nature 539 (7627), 112-117, 2016 | 666 | 2016 |
| A robust and cost-effective method for the production of Val, Leu, Ile (δ1) methyl-protonated 15N-, 13C-, 2H-labeled proteins NK Goto, KH Gardner, GA Mueller, RC Willis, LE Kay Journal of biomolecular NMR 13, 369-374, 1999 | 637 | 1999 |
| White collar-1, a DNA binding transcription factor and a light sensor Q He, P Cheng, Y Yang, L Wang, KH Gardner, Y Liu Science 297 (5582), 840-843, 2002 | 514 | 2002 |
| Evolutionary information for specifying a protein fold M Socolich, SW Lockless, WP Russ, H Lee, KH Gardner, R Ranganathan Nature 437 (7058), 512-518, 2005 | 512 | 2005 |
| An optogenetic gene expression system with rapid activation and deactivation kinetics LB Motta-Mena, A Reade, MJ Mallory, S Glantz, OD Weiner, KW Lynch, ... Nature chemical biology 10 (3), 196-202, 2014 | 391 | 2014 |
| Selective methyl group protonation of perdeuterated proteins MK Rosen, KH Gardner, RC Willis, WE Parris, T Pawson, LE Kay Journal of molecular biology 263 (5), 627-636, 1996 | 372 | 1996 |
| Disruption of the LOV− Jα helix interaction activates phototropin kinase activity SM Harper, JM Christie, KH Gardner Biochemistry 43 (51), 16184-16192, 2004 | 367 | 2004 |
| Production and incorporation of 15N, 13C, 2H (1H-δ1 methyl) isoleucine into proteins for multidimensional NMR studies KH Gardner, LE Kay Journal of the American Chemical Society 119 (32), 7599-7600, 1997 | 345 | 1997 |
| Global folds of highly deuterated, methyl-protonated proteins by multidimensional NMR KH Gardner, MK Rosen, LE Kay Biochemistry 36 (6), 1389-1401, 1997 | 335 | 1997 |
| Allosteric inhibition of hypoxia inducible factor-2 with small molecules TH Scheuermann, Q Li, HW Ma, J Key, L Zhang, R Chen, JA Garcia, ... Nature chemical biology 9 (4), 271-276, 2013 | 315 | 2013 |
| Artificial ligand binding within the HIF2α PAS-B domain of the HIF2 transcription factor TH Scheuermann, DR Tomchick, M Machius, Y Guo, RK Bruick, ... Proceedings of the National Academy of Sciences 106 (2), 450-455, 2009 | 308 | 2009 |
| Structural basis for PAS domain heterodimerization in the basic helix–loop–helix-PAS transcription factor hypoxia-inducible factor PJA Erbel, PB Card, O Karakuzu, RK Bruick, KH Gardner Proceedings of the National Academy of Sciences 100 (26), 15504-15509, 2003 | 273 | 2003 |
| Solution NMR spectroscopy beyond 25 kDa LE Kay, KH Gardner Current opinion in structural biology 7 (5), 722-731, 1997 | 244 | 1997 |
| Identification of small-molecule antagonists that inhibit an activator: coactivator interaction JL Best, CA Amezcua, B Mayr, L Flechner, CM Murawsky, B Emerson, ... Proceedings of the National Academy of Sciences 101 (51), 17622-17627, 2004 | 239 | 2004 |
| Rationally improving LOV domain–based photoswitches D Strickland, X Yao, G Gawlak, MK Rosen, KH Gardner, TR Sosnick Nature methods 7 (8), 623-626, 2010 | 229 | 2010 |
| PAS domain-mediated WC-1/WC-2 interaction is essential for maintaining the steady-state level of WC-1 and the function of both proteins in circadian clock and light responses … P Cheng, Y Yang, KH Gardner, Y Liu Molecular and Cellular Biology 22 (2), 517-524, 2002 | 219 | 2002 |
| Structural basis of photosensitivity in a bacterial light-oxygen-voltage/helix-turn-helix (LOV-HTH) DNA-binding protein AI Nash, R McNulty, ME Shillito, TE Swartz, RA Bogomolni, H Luecke, ... Proceedings of the National Academy of Sciences 108 (23), 9449-9454, 2011 | 216 | 2011 |
| Structure of a bacterial BLUF photoreceptor: insights into blue light-mediated signal transduction A Jung, T Domratcheva, M Tarutina, Q Wu, W Ko, RL Shoeman, ... Proceedings of the National Academy of Sciences 102 (35), 12350-12355, 2005 | 216 | 2005 |
Lewis E KayUniversity of Toronto在 pound.med.utoronto.ca 的电子邮件经过验证
