A modular approach to the ECVAM principles on test validity T Hartung, S Bremer, S Casati, S Coecke, R Corvi, S Fortaner, L Gribaldo, ... Alternatives to Laboratory Animals 32 (5), 467-472, 2004 | 375 | 2004 |
“ToxRTool”, a new tool to assess the reliability of toxicological data K Schneider, M Schwarz, I Burkholder, A Kopp-Schneider, L Edler, ... Toxicology letters 189 (2), 138-144, 2009 | 334 | 2009 |
The ECVAM international validation study on in vitro tests for acute skin irritation: report on the validity of the EPISKIN and EpiDerm assays and on the Skin Integrity … H Spielmann, S Hoffmann, M Liebsch, P Botham, JH Fentem, C Eskes, ... Alternatives to Laboratory Animals 35 (6), 559-601, 2007 | 248 | 2007 |
A roadmap for the development of alternative (non-animal) methods for systemic toxicity testing D Basketter, H Clewell, I Kimber, A Rossi, B Blaauboer, R Burrier, ... | 247 | 2012 |
International validation of novel pyrogen tests based on human monocytoid cells S Hoffmann, A Peterbauer, S Schindler, S Fennrich, S Poole, Y Mistry, ... Journal of immunological methods 298 (1-2), 161-173, 2005 | 235 | 2005 |
Categorization of chemicals according to their relative human skin sensitizing potency DA Basketter, N Alépée, T Ashikaga, J Barroso, N Gilmour, C Goebel, ... Dermatitis 25 (1), 11-21, 2014 | 219 | 2014 |
A proposed eye irritation testing strategy to reduce and replace in vivo studies using bottom–up and top–down approaches L Scott, C Eskes, S Hoffmann, E Adriaens, N Alepée, M Bufo, R Clothier, ... Toxicology in Vitro 24 (1), 1-9, 2010 | 206 | 2010 |
Integrated Testing Strategies (ITS) for safety assessment. C Rovida, N Alépée, AM Api, DA Basketter, F y Bois, F Caloni, E Corsini, ... ALTEX-Alternatives to Animal Experimentations 32 (1), 25-40, 2015 | 173 | 2015 |
ECVAM retrospective validation of in vitro micronucleus test (MNT) R Corvi, S Albertini, T Hartung, S Hoffmann, D Maurici, S Pfuhler, ... Mutagenesis 23 (4), 271-283, 2008 | 173 | 2008 |
Non-animal methods to predict skin sensitization (II): an assessment of defined approaches NC Kleinstreuer, S Hoffmann, N Alépée, D Allen, T Ashikaga, W Casey, ... Critical reviews in toxicology 48 (5), 359-374, 2018 | 170 | 2018 |
Toward an evidence-based toxicology S Hoffmann, T Hartung Human & experimental toxicology 25 (9), 497-513, 2006 | 161 | 2006 |
Non-animal methods to predict skin sensitization (I): the Cosmetics Europe database S Hoffmann, N Kleinstreuer, N Alépée, D Allen, AM Api, T Ashikaga, ... Critical reviews in toxicology 48 (5), 344-358, 2018 | 154 | 2018 |
Systematic evaluation of non-animal test methods for skin sensitisation safety assessment K Reisinger, S Hoffmann, N Alépée, T Ashikaga, J Barroso, C Elcombe, ... Toxicology in Vitro 29 (1), 259-270, 2015 | 150 | 2015 |
Food for thought... on in silico methods in toxicology T Hartung, S Hoffmann ALTEX-Alternatives to animal experimentation 26 (3), 155-166, 2009 | 118 | 2009 |
Heterozygous toll-like receptor 4 polymorphism does not influence lipopolysaccharide-induced cytokine release in human whole blood S Von Aulock, NWJ Schröder, K Gueinzius, S Traub, S Hoffmann, K Graf, ... The Journal of infectious diseases 188 (6), 938-943, 2003 | 104 | 2003 |
Retrospective analysis of the Draize test for serious eye damage/eye irritation: importance of understanding the in vivo endpoints under UN GHS/EU CLP for the development and … E Adriaens, J Barroso, C Eskes, S Hoffmann, P McNamee, N Alépée, ... Archives of toxicology 88, 701-723, 2014 | 102 | 2014 |
International validation of pyrogen tests based on cryopreserved human primary blood cells S Schindler, I Spreitzer, B Löschner, S Hoffmann, K Hennes, M Halder, ... Journal of immunological methods 316 (1-2), 42-51, 2006 | 101 | 2006 |
Food for thought... Mechanistic validation T Hartung, S Hoffmann, M Stephens Altex 30 (2), 119, 2013 | 93 | 2013 |
Implementing systematic review techniques in chemical risk assessment: Challenges, opportunities and recommendations P Whaley, C Halsall, M Ågerstrand, E Aiassa, D Benford, G Bilotta, ... Environment international 92, 556-564, 2016 | 91 | 2016 |
The principles of weight of evidence validation of test methods and testing strategies: The report and recommendations of ECVAM workshop 58 M Balls, P Amcoff, S Bremer, S Casati, S Coecke, R Clothier, R Combes, ... Alternatives to laboratory animals 34 (6), 603-620, 2006 | 86 | 2006 |