Acylpeptide hydrolase inhibition as targeted strategy to induce proteasomal down-regulation G Palmieri, P Bergamo, A Luini, M Ruvo, M Gogliettino, E Langella, ... PloS one 6 (10), e25888, 2011 | 57 | 2011 |
Identification of p38 MAPK and JNK as new targets for correction of Wilson disease‐causing ATP7B mutants G Chesi, RN Hegde, S Iacobacci, M Concilli, S Parashuraman, BP Festa, ... Hepatology 63 (6), 1842-1859, 2016 | 50 | 2016 |
TBK1 phosphorylates mutant Huntingtin and suppresses its aggregation and toxicity in Huntington's disease models RN Hegde, A Chiki, L Petricca, P Martufi, N Arbez, L Mouchiroud, ... The EMBO journal 39 (17), e104671, 2020 | 37 | 2020 |
A NAC domain mutation (E83Q) unlocks the pathogenicity of human alpha-synuclein and recapitulates its pathological diversity ST Kumar, AL Mahul-Mellier, RN Hegde, G Rivière, R Moons, ... Science advances 8 (17), eabn0044, 2022 | 36 | 2022 |
Unravelling druggable signalling networks that control F508del-CFTR proteostasis RN Hegde, S Parashuraman, F Iorio, F Ciciriello, F Capuani, A Carissimo, ... Elife 4, e10365, 2015 | 30 | 2015 |
Revisiting the specificity and ability of phospho-S129 antibodies to capture alpha-synuclein biochemical and pathological diversity HA Lashuel, AL Mahul-Mellier, S Novello, RN Hegde, Y Jasiqi, MF Altay, ... npj Parkinson's Disease 8 (1), 136, 2022 | 22 | 2022 |
Site‐specific phosphorylation of Huntingtin exon 1 recombinant proteins enabled by the discovery of novel kinases C Anass, R Jonathan, H Ramanath, Narayana, A Luciano, A, R Andreas, ... ChemBioChem, 2020 | 20* | 2020 |
The unique enzymatic function of field bean (Dolichos lablab) d-galactose specific lectin: a polyphenol oxidase SR Kanade, DH Rao, RN Hegde, LR Gowda Glycoconjugate journal 26, 535-545, 2009 | 15 | 2009 |
Rare ER protein misfolding-mistrafficking disorders: therapeutic developments RN Hegde, A Subramanian, P Pothukuchi, S Parashuraman, A Luini Tissue and Cell 49 (2), 175-185, 2017 | 14 | 2017 |
Neighbouring modifications interfere with the detection of phosphorylated alpha-synuclein at Serine 129: Revisiting the specificity of pS129 antibodies HA Lashuel, AL Mahul-Mellier, S Novello, RN Hegde, Y Jasiqi, MF Altay, ... bioRxiv, 2022.03. 30.486322, 2022 | 3 | 2022 |
TBK1 regulates autophagic clearance of soluble mutant huntingtin and inhibits aggregation/toxicity in different models of Huntington’s disease RN Hegde, A Chiki, L Petricca, P Martufi, N Arbez, L Mouchiroud, ... bioRxiv, 869586, 2019 | 2 | 2019 |
Kinase and ubiquitin ligase inhibitors and uses thereof A Luini, AR Beccari, RN Hegde, S Parashuraman | | 2017 |
Modulation of proteostasis for the efficient intracellular transport of the ΔF508 mutant of cystic fibrosis transmembrane conductance regulator RN Hegde PQDT-Global, 2014 | | 2014 |
Stress activated MAPK influence the quality control of misfolded cystic fibrosis transmembrane conductance regulator. RN Hegde, S Parashuraman, F Iorio, D Di Bernardo, A Luini The FASEB Journal 27, lb126-lb126, 2013 | | 2013 |