Site-selective C–C modification of proteins at neutral pH using organocatalyst-mediated cross aldol ligations RJ Spears, RL Brabham, D Budhadev, T Keenan, S McKenna, J Walton, ... Chemical Science 9 (25), 5585-5593, 2018 | 45 | 2018 |
Introducing affinity and selectivity into galectin-targeting nanoparticles with fluorinated glycan ligands SJ Richards, T Keenan, JB Vendeville, DE Wheatley, H Chidwick, ... Chemical science 12 (3), 905-910, 2021 | 31 | 2021 |
Cell-specific bioorthogonal tagging of glycoproteins A Cioce, B Calle, T Rizou, SC Lowery, VL Bridgeman, KE Mahoney, ... Nature Communications 13 (1), 6237, 2022 | 23 | 2022 |
Profiling substrate promiscuity of wild-type sugar kinases for multi-fluorinated monosaccharides T Keenan, F Parmeggiani, J Malassis, CQ Fontenelle, JB Vendeville, ... Cell Chemical Biology 27 (9), 1199-1206. e5, 2020 | 20 | 2020 |
Reconstitution and optimisation of the biosynthesis of bacterial sugar pseudaminic acid (Pse5Ac7Ac) enables preparative enzymatic synthesis of CMP-Pse5Ac7Ac HS Chidwick, EKP Flack, T Keenan, J Walton, GH Thomas, MA Fascione Scientific Reports 11 (1), 4756, 2021 | 15 | 2021 |
Characterization of the Streptomyces coelicolor glycoproteome reveals glycoproteins important for cell wall biogenesis T Keenan, A Dowle, R Bates, MCM Smith MBio 10 (3), 10.1128/mbio. 01092-19, 2019 | 14 | 2019 |
Rapid sodium periodate cleavage of an unnatural amino acid enables unmasking of a highly reactive α-oxo aldehyde for protein bioconjugation RL Brabham, T Keenan, A Husken, J Bilsborrow, R McBerney, V Kumar, ... Organic & Biomolecular Chemistry 18 (21), 4000-4003, 2020 | 12 | 2020 |
Biocatalytic transfer of pseudaminic acid (Pse5Ac7Ac) using promiscuous sialyltransferases in a chemoenzymatic approach to Pse5Ac7Ac-containing glycosides EKP Flack, HS Chidwick, G Guchhait, T Keenan, D Budhadev, K Huang, ... ACS Catalysis 10 (17), 9986-9993, 2020 | 11 | 2020 |
The characterisation of a galactokinase from Streptomyces coelicolor T Keenan, R Mills, E Pocock, D Budhadev, F Parmeggiani, S Flitsch, ... Carbohydrate research 472, 132-137, 2019 | 10 | 2019 |
Chemoenzymatic synthesis of 3-deoxy-3-fluoro-l-fucose and its enzymatic incorporation into glycoconjugates P Valverde, JB Vendeville, K Hollingsworth, AP Mattey, T Keenan, ... Chemical Communications 56 (47), 6408-6411, 2020 | 8 | 2020 |
A Tale of Two Bioconjugations: pH Controlled Divergent Reactivity of Protein α-oxo-Aldehydes in Competing α-oxo-Mannich and Catalyst-Free Aldol Ligations T Keenan, RJ Spears, S Akkad, CS Mahon, NE Hatton, J Walton, A Noble, ... ACS Chemical Biology 16 (11), 2387-2400, 2021 | 4 | 2021 |
The Retaining Pse5Ac7Ac Pseudaminyltransferase KpsS1 Defines a Previously Unreported glycosyltransferase family (GT118) AJ Walklett, EKP Flack, HS Chidwick, NE Hatton, T Keenan, D Budhadev, ... Angewandte Chemie 136 (15), e202318523, 2024 | 3 | 2024 |
Catalyst-free site-selective cross-aldol bioconjugations NDJ Yates, S Akkad, A Noble, T Keenan, NE Hatton, N Signoret, ... Green Chemistry 24 (20), 8046-8053, 2022 | 3 | 2022 |
Chemical Bioconjugation of Proteins in an Undergraduate Lab: One-Pot Oxidation and Derivatization of the N-Terminus NDJ Yates, RL Brabham, RJ Spears, T Keenan, PA Helliwell, DS Pugh, ... Journal of Chemical Education 96 (6), 1245-1249, 2019 | 3 | 2019 |
Characterization of the Streptomyces coelicolor glycoproteome reveals glycoproteins important for cell wall biogenesis. mBio 10: e01092-19 T Keenan, A Dowle, R Bates, MCM Smith | 2 | 2019 |
Cross aldol OPAL bioconjugation outcompetes intramolecular hemiaminal cyclisation of proline adjacent N-terminal α-oxo aldehydes at acidic pH A Tufail, S Akkad, NE Hatton, NDJ Yates, RJ Spears, T Keenan, A Parkin, ... RSC advances 14 (6), 3723-3729, 2024 | 1 | 2024 |
The retaining Pse5Ac7Ac pseudaminyltransferase KpsS1 defines a new glycosyltransferase family (GTXXX) A Walklett, E Flack, H Chidwick, N Hatton, T Keenan, D Budhadev, ... | 1 | 2023 |
A ‘glyco-fluorine’code revealing differential recognition by glycan binding partners K Hollingsworth, A Di Maio, SJ Richards, JB Vendeville, DE Wheatley, ... | 1 | 2023 |
SUPPLEMENTARY INFORMATION: In the G Beard RIN 7, 25-99, 2005 | 1 | 2005 |
3’-O-β-Glycosylation of nucleoside analogues using a promiscuous bacterial glycosyltransferase J Dolan, T Keenan, C Benckendorff, A Ní Cheallaigh, M Fascione, G Miller | | 2024 |