Aryl and heteroaryllithium compounds by metal-halogen exchange. Synthesis of carbocyclic and heterocyclic systems N Sotomayor, E Lete Current Organic Chemistry 7 (3), 275-300, 2003 | 137 | 2003 |
General theory for multiple input-output perturbations in complex molecular systems. 1. Linear QSPR electronegativity models in physical, organic, and medicinal chemistry H Gonzalez-Diaz, S Arrasate, A Gomez-SanJuan, N Sotomayor, E Lete, ... Current topics in medicinal chemistry 13 (14), 1713-1741, 2013 | 126 | 2013 |
Metalation vs nucleophilic addition in the reactions of N-phenethylimides with organolithium reagents. Ready access to isoquinoline derivatives via N-acyliminium ions and … MI Collado, I Manteca, N Sotomayor, MJ Villa, E Lete The Journal of Organic Chemistry 62 (7), 2080-2092, 1997 | 115 | 1997 |
Bischler−Napieralski Cyclization−N/C-Alkylation Sequences for the Construction of Isoquinoline Alkaloids. Synthesis of Protoberberines and Benzo[c]phenanthridines via C … N Sotomayor, E Domínguez, E Lete The Journal of Organic Chemistry 61 (12), 4062-4072, 1996 | 107 | 1996 |
Brønsted acid catalyzed enantioselective α-amidoalkylation in the synthesis of isoindoloisoquinolines E Aranzamendi, N Sotomayor, E Lete The Journal of Organic Chemistry 77 (6), 2986-2991, 2012 | 76 | 2012 |
Tandem Parham cyclisation––α-amidoalkylation reaction in the synthesis of the isoindolo [1, 2-a] isoquinoline skeleton of nuevamine-type alkaloids I Osante, E Lete, N Sotomayor Tetrahedron letters 45 (6), 1253-1256, 2004 | 68 | 2004 |
Parham-type cycliacylation with Weinreb amides. Application to the synthesis of fused indolizinone systems J Ruiz, N Sotomayor, E Lete Organic letters 5 (7), 1115-1117, 2003 | 65 | 2003 |
Enantiodivergent Synthesis of Pyrrolo[2,1-a]isoquinolines Based on Diastereoselective Parham Cyclization and α-Amidoalkylation Reactions I González-Temprano, I Osante, E Lete, N Sotomayor The Journal of Organic Chemistry 69 (11), 3875-3885, 2004 | 63 | 2004 |
An efficient entry to pyrrolo [1, 2-b] isoquinolines and related systems through Parham cyclisation J Ruiz, A Ardeo, R Ignacio, N Sotomayor, E Lete Tetrahedron 61 (13), 3311-3324, 2005 | 62 | 2005 |
A practical approach to the fused β-carboline system. asymmetric synthesis of indolo [2, 3-a] indolizidinones via a diastereoselective intramolecular α-amidoalkylation reaction A Ardeo, E Garcı́a, S Arrasate, E Lete, N Sotomayor Tetrahedron Letters 44 (46), 8445-8448, 2003 | 54 | 2003 |
Synthesis of enantiomerically enriched amines by chiral ligand mediated addition of organolithium reagents to imines S Arrasate, E Lete, N Sotomayor Tetrahedron: Asymmetry 12 (14), 2077-2082, 2001 | 54 | 2001 |
Strategies Based on Aryllithium and N‐Acyliminium Ion Cyclizations for the Stereocontrolled Synthesis of Alkaloids and Related Systems U Martínez‐Estibalez, A Gómez‐SanJuan, O García‐Calvo, ... European Journal of Organic Chemistry 2011 (20‐21), 3610-3633, 2011 | 53 | 2011 |
Modeling antibacterial activity with machine learning and fusion of chemical structure information with microorganism metabolic networks D Nocedo-Mena, C Cornelio, MR Camacho-Corona, E Garza-González, ... Journal of chemical information and modeling 59 (3), 1109-1120, 2019 | 52 | 2019 |
Diastereoselective Intramolecular α-Amidoalkylation Reactions of l-DOPA Derivatives. Asymmetric Synthesis of Pyrrolo[2,1-a]isoquinolines E García, S Arrasate, E Lete, N Sotomayor The Journal of Organic Chemistry 70 (25), 10368-10374, 2005 | 52 | 2005 |
Functionalized organolithium compounds: generation via reductive lithiation and nucleophilic addition to N-phenethylimides. Access to functionalized dihydropyrrolo [2, 1-a … I Manteca, B Etxarri, A Ardeo, S Arrasate, I Osante, N Sotomayor, E Lete Tetrahedron 54 (40), 12361-12378, 1998 | 52 | 1998 |
Intramolecular Palladium‐Catalyzed Direct Arylation vs. Heck Reactions: Synthesis of Pyrroloisoquinolines and Isoindoles S Lage, U Martínez‐Estíbalez, N Sotomayor, E Lete Advanced Synthesis & Catalysis 351 (14‐15), 2460-2468, 2009 | 50 | 2009 |
Perturbation-theory and machine learning (PTML) model for high-throughput screening of parham reactions: experimental and theoretical studies L Simón-Vidal, O García-Calvo, U Oteo, S Arrasate, E Lete, N Sotomayor, ... Journal of Chemical Information and Modeling 58 (7), 1384-1396, 2018 | 47 | 2018 |
Pd-catalyzed arylation/ring-closing metathesis approach to azabicycles U Martínez-Estíbalez, N Sotomayor, E Lete Tetrahedron letters 48 (16), 2919-2922, 2007 | 44 | 2007 |
α-Aryl O-vinyl carbamates. Tandem carbolithiation—α-alkylation and-[1, 2]-Wittig rearrangement reactions S Superchi, N Sotomayor, G Miao, B Joseph, MG Campbell, V Snieckus Tetrahedron letters 37 (34), 6061-6064, 1996 | 44 | 1996 |
Intramolecular Direct Arylation and Heck Reactions in the Formation of Medium‐Sized Rings: Selective Synthesis of Fused Indolizine, Pyrroloazepine and Pyrroloazocine Systems E Coya, N Sotomayor, E Lete Advanced Synthesis & Catalysis 356 (8), 1853-1865, 2014 | 43 | 2014 |