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Jun Chen
Jun Chen
在 gene.com 的电子邮件经过验证
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A structural basis for drug-induced long QT syndrome
JS Mitcheson, J Chen, M Lin, C Culberson, MC Sanguinetti
Proceedings of the National Academy of Sciences 97 (22), 12329-12333, 2000
11462000
Selective blockade of TRPA1 channel attenuates pathological pain without altering noxious cold sensation or body temperature regulation
J Chen, SK Joshi, S DiDomenico, RJ Perner, JP Mikusa, DM Gauvin, ...
Pain 152 (5), 1165-1172, 2011
3192011
Trapping of a methanesulfonanilide by closure of the HERG potassium channel activation gate
JS Mitcheson, J Chen, MC Sanguinetti
The Journal of general physiology 115 (3), 229-240, 2000
3022000
Species differences and molecular determinant of TRPA1 cold sensitivity
J Chen, D Kang, J Xu, M Lake, JO Hogan, C Sun, K Walter, B Yao, D Kim
Nature communications 4 (1), 2501, 2013
2922013
Long QT syndrome-associated mutations in the Per-Arnt-Sim (PAS) domain of HERG potassium channels accelerate channel deactivation
J Chen, A Zou, I Splawski, MT Keating, MC Sanguinetti
Journal of Biological Chemistry 274 (15), 10113-10118, 1999
2821999
ALARM NMR: a rapid and robust experimental method to detect reactive false positives in biochemical screens
JR Huth, R Mendoza, ET Olejniczak, RW Johnson, DA Cothron, Y Liu, ...
Journal of the American Chemical Society 127 (1), 217-224, 2005
2512005
Position of aromatic residues in the S6 domain, not inactivation, dictates cisapride sensitivity of HERG and eag potassium channels
J Chen, G Seebohm, MC Sanguinetti
Proceedings of the National Academy of Sciences 99 (19), 12461-12466, 2002
2272002
Structural basis of Nav1. 7 inhibition by a gating-modifier spider toxin
H Xu, T Li, A Rohou, CP Arthur, F Tzakoniati, E Wong, A Estevez, C Kugel, ...
Cell 176 (4), 702-715. e14, 2019
2222019
Molecular determinants of voltage-dependent human ether-a-go-go related gene (HERG) K+ channel block
JA Sánchez-Chapula, RA Navarro-Polanco, C Culberson, J Chen, ...
Journal of Biological Chemistry 277 (26), 23587-23595, 2002
2072002
Interactions between S4-S5 linker and S6 transmembrane domain modulate gating of HERG K+ channels
M Tristani-Firouzi, J Chen, MC Sanguinetti
Journal of Biological Chemistry 277 (21), 18994-19000, 2002
1942002
TRPA1 as a drug target—promise and challenges
J Chen, DH Hackos
Naunyn-Schmiedeberg's archives of pharmacology 388, 451-463, 2015
1912015
Molecular biology of K+ channels and their role in cardiac arrhythmias
M Tristani-Firouzi, J Chen, JS Mitcheson, MC Sanguinetti
The American journal of medicine 110 (1), 50-59, 2001
1912001
The S4–S5 linker couples voltage sensing and activation of pacemaker channels
J Chen, JS Mitcheson, M Tristani-Firouzi, M Lin, MC Sanguinetti
Proceedings of the National Academy of Sciences 98 (20), 11277-11282, 2001
1852001
Voltage-dependent gating of hyperpolarization-activated, cyclic nucleotide-gated pacemaker channels: molecular coupling between the S4–S5 and C-linkers
N Decher, J Chen, MC Sanguinetti
Journal of Biological Chemistry 279 (14), 13859-13865, 2004
1482004
Pore dilation occurs in TRPA1 but not in TRPM8 channels
J Chen, D Kim, BR Bianchi, EJ Cavanaugh, CR Faltynek, PR Kym, ...
Molecular pain 5, 1744-8069-5-3, 2009
1422009
Transient receptor potential A1 mediates an osmotically activated ion channel
XF Zhang, J Chen, CR Faltynek, RB Moreland, TR Neelands
European Journal of Neuroscience 27 (3), 605-611, 2008
1282008
Molecular determinants of species-specific activation or blockade of TRPA1 channels
J Chen, XF Zhang, ME Kort, JR Huth, C Sun, LJ Miesbauer, SC Cassar, ...
Journal of Neuroscience 28 (19), 5063-5071, 2008
1272008
Functional roles of charged residues in the putative voltage sensor of the HCN2 pacemaker channel
J Chen, JS Mitcheson, M Lin, MC Sanguinetti
Journal of Biological Chemistry 275 (46), 36465-36471, 2000
1172000
Pharmacological activation of normal and arrhythmia-associated mutant KCNQ1 potassium channels
G Seebohm, M Pusch, J Chen, MC Sanguinetti
Circulation research 93 (10), 941-947, 2003
1072003
Molecular determinants of KCNQ1 channel block by a benzodiazepine
G Seebohm, J Chen, N Strutz, C Culberson, C Lerche, MC Sanguinetti
Molecular pharmacology 64 (1), 70-77, 2003
1052003
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