The PTEN/PI3K/AKT signalling pathway in cancer, therapeutic implications A Carnero, C Blanco-Aparicio, O Renner, W Link, JFM Leal Current cancer drug targets 8 (3), 187-198, 2008 | 1033 | 2008 |
Somatodendritic expression of an immediate early gene is regulated by synaptic activity. W Link, UWE Konietzko, G Kauselmann, M Krug, B Schwanke, U Frey, ... Proceedings of the National Academy of Sciences 92 (12), 5734-5738, 1995 | 841 | 1995 |
DREAM is a Ca2+-regulated transcriptional repressor AM Carrion, WA Link, F Ledo, B Mellström, JR Naranjo Nature 398 (6722), 80-84, 1999 | 732 | 1999 |
Long live FOXO: unraveling the role of FOXO proteins in aging and longevity R Martins, GJ Lithgow, W Link Aging cell 15 (2), 196-207, 2016 | 683 | 2016 |
High content screening: seeing is believing F Zanella, JB Lorens, W Link Trends in biotechnology 28 (5), 237-245, 2010 | 504 | 2010 |
Protein localization in disease and therapy MC Hung, W Link Journal of cell science 124 (20), 3381-3392, 2011 | 477 | 2011 |
Components and regulation of nuclear transport processes B Cautain, R Hill, N de Pedro, W Link The FEBS journal 282 (3), 445-462, 2015 | 304 | 2015 |
Therapeutic strategies targeting FOXO transcription factors G Calissi, EWF Lam, W Link Nature reviews Drug discovery 20 (1), 21-38, 2021 | 198 | 2021 |
Introduction to FOXO biology W Link FOXO Transcription Factors: Methods and Protocols, 1-9, 2019 | 143 | 2019 |
Targeting nucleocytoplasmic transport in cancer therapy R Hill, B Cautain, N De Pedro, W Link Oncotarget 5 (1), 11, 2014 | 135 | 2014 |
Human TRIB2 is a repressor of FOXO that contributes to the malignant phenotype of melanoma cells F Zanella, O Renner, B García, S Callejas, A Dopazo, S Peregrina, ... Oncogene 29 (20), 2973-2982, 2010 | 126 | 2010 |
DREAM-αCREM interaction via leucine-charged domains derepresses downstream regulatory element-dependent transcription F Ledo, AM Carrión, WA Link, B Mellström, JR Naranjo Molecular and cellular biology, 2000 | 116 | 2000 |
Interleukin 3-dependent activation of DREAM is involved in transcriptional silencing of the apoptotic Hrk gene in hematopoietic progenitor cells C Sanz, B Mellstrom, WA Link, JR Naranjo, JL Fernandez-Luna The EMBO journal 20 (9), 2286-2292, 2001 | 114 | 2001 |
CRISPR/Cas9‐mediated genome editing: From basic research to translational medicine FV Jacinto, W Link, BI Ferreira Journal of cellular and molecular medicine 24 (7), 3766-3778, 2020 | 108 | 2020 |
FOXO transcription factors at the interface of metabolism and cancer W Link, PJ Fernandez‐Marcos International journal of cancer 141 (12), 2379-2391, 2017 | 101 | 2017 |
Day-night changes in downstream regulatory element antagonist modulator/potassium channel interacting protein activity contribute to circadian gene expression in pineal gland WA Link, F Ledo, B Torres, M Palczewska, TM Madsen, M Savignac, ... Journal of Neuroscience 24 (23), 5346-5355, 2004 | 101 | 2004 |
Chemical interrogation of FOXO3a nuclear translocation identifies potent and selective inhibitors of phosphoinositide 3-kinases W Link, J Oyarzabal, BG Serelde, MI Albarran, O Rabal, A Cebriá, ... Journal of Biological Chemistry 284 (41), 28392-28400, 2009 | 99 | 2009 |
Chemical Genetic Analysis of FOXO Nuclear–Cytoplasmic Shuttling by Using Image‐Based Cell Screening F Zanella, A Rosado, B García, A Carnero, W Link Chembiochem 9 (14), 2229-2237, 2008 | 93 | 2008 |
RETRACTED ARTICLE: TRIB2 confers resistance to anti-cancer therapy by activating the serine/threonine protein kinase AKT R Hill, PA Madureira, B Ferreira, I Baptista, S Machado, L Colaco, ... Nature communications 8 (1), 14687, 2017 | 84 | 2017 |
A novel imaging‐based high‐throughput screening approach to anti‐angiogenic drug discovery L Evensen, DR Micklem, W Link, JB Lorens Cytometry Part A: The Journal of the International Society for Advancement …, 2010 | 64 | 2010 |