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Steven Gunawan
Steven Gunawan
在 moffitt.org 的电子邮件经过验证 - 首页
标题
引用次数
引用次数
年份
Selective inhibition of leukemia-associated SHP2E69K mutant by the allosteric SHP2 inhibitor SHP099
X Sun, Y Ren, S Gunawan, P Teng, Z Chen, HR Lawrence, J Cai, ...
Leukemia 32 (5), 1246-1249, 2018
672018
Structural insights into JAK2 inhibition by ruxolitinib, fedratinib, and derivatives thereof
RR Davis, B Li, SY Yun, A Chan, P Nareddy, S Gunawan, M Ayaz, ...
Journal of medicinal chemistry 64 (4), 2228-2241, 2021
622021
Bifunctional building blocks in the Ugi-azide condensation reaction: a general strategy toward exploration of new molecular diversity
S Gunawan, C Hulme
Organic & biomolecular chemistry 11 (36), 6036-6046, 2013
622013
Synthesis of tetrazolo-fused benzodiazepines and benzodiazepinones by a two-step protocol using an Ugi-azide reaction for initial diversity generation
S Gunawan, M Ayaz, F De Moliner, B Frett, C Kaiser, N Patrick, Z Xu, ...
Tetrahedron 68 (27-28), 5606-5611, 2012
622012
Concise one-pot preparation of unique bis-pyrrolidinone tetrazoles
S Gunawan, J Petit, C Hulme
ACS Combinatorial Science 14 (3), 160-163, 2012
512012
Potent dual BET bromodomain-kinase inhibitors as value-added multitargeted chemical probes and cancer therapeutics
SW Ember, QT Lambert, N Berndt, S Gunawan, M Ayaz, M Tauro, JY Zhu, ...
Molecular cancer therapeutics 16 (6), 1054-1067, 2017
502017
Targeting Aurora kinase A and JAK2 prevents GVHD while maintaining Treg and antitumor CTL function
BC Betts, A Veerapathran, J Pidala, H Yang, P Horna, K Walton, CL Cubitt, ...
Science translational medicine 9 (372), eaai8269, 2017
442017
Ligand-mediated protein degradation reveals functional conservation among sequence variants of the CUL4-type E3 ligase substrate receptor cereblon
AA Akuffo, AY Alontaga, R Metcalf, MS Beatty, A Becker, JM McDaniel, ...
Journal of Biological Chemistry 293 (16), 6187-6200, 2018
432018
Targeting the BRD4-HOXB13 coregulated transcriptional networks with bromodomain-kinase inhibitors to suppress metastatic castration-resistant prostate cancer
N Nerlakanti, J Yao, DT Nguyen, AK Patel, AM Eroshkin, HR Lawrence, ...
Molecular cancer therapeutics 17 (12), 2796-2810, 2018
322018
Concise route to a series of novel 3-(tetrazol-5-yl) quinoxalin-2 (1H)-ones
S Gunawan, G Nichol, C Hulme
Tetrahedron letters 53 (13), 1664-1667, 2012
302012
Concise preparation of novel tricyclic chemotypes: fused hydantoin–benzodiazepines
S Gunawan, GS Nichol, S Chappeta, J Dietrich, C Hulme
Tetrahedron letters 51 (36), 4689-4692, 2010
222010
Construction of functionalized tricyclic dihydropyrazino-quinazolinedione chemotypes via an Ugi/N-acyliminium ion cyclization cascade
S Gunawan, C Hulme
Tetrahedron letters 54 (33), 4467-4470, 2013
192013
Synthesis of peptidomimetics, δ-and-lactam tetrazoles
S Gunawan, K Keck, A Laetsch, C Hulme
Molecular diversity 16 (3), 601-606, 2012
192012
Differential BET bromodomain inhibition by dihydropteridinone and pyrimidodiazepinone kinase inhibitors
RM Karim, MJ Bikowitz, A Chan, JY Zhu, D Grassie, A Becker, N Berndt, ...
Journal of medicinal chemistry 64 (21), 15772-15786, 2021
132021
Efficient synthesis of indole derivatives containing the tetrazole moeity utilizing an Ugi-Azide post-transformation strategy
A Nikbakht, S Balalaie, F Baghestani, F Rominger
Synlett 29 (14), 1892-1896, 2018
102018
Mutation selectivity of the allosteric SHP2 inhibitor SHP099
X Sun, Y Ren, S Gunawan, P Teng, Z Chen, HR Lawrence, J Cai, ...
Cancer Research 78 (13_Supplement), 4879-4879, 2018
22018
2-Butyl-11-phenyl-5, 10-dihydro-1H-benzo [e] imidazo [1, 5-a][1, 4] diazepine-1, 3 (2H)-dione
GS Nichol, S Gunawan, J Dietrich, C Hulme
Acta Crystallographica Section E: Structure Reports Online 66 (3), o625-o625, 2010
22010
Intracellular protein degradation of BRD4 by dBET1 reveals conserved in vivo cereblon function in human and mouse T-cells
AA Akuffo, A Alontaga, R Metclaf, MS Beatty, J McDaniel, S Gunawan, ...
The Journal of Immunology 198 (1_Supplement), 52.18-52.18, 2017
12017
Targeting the acetyl-lysine binding site of BRD4 with dual nanomolar BET-JAK2 inhibitors: A new anticancer therapeutic strategy
S Gunawan, A Muhammad, SWJ Ember, JY Zhu, RA Jacobsen, N Berndt, ...
Cancer Research 75 (15_Supplement), 3643-3643, 2015
12015
2-Propyl 3, 3-dibromo-2-hydroxypyrrolidine-1-carboxylate
GS Nichol, S Gunawan, Z Xu, J Dietrich, C Hulme
Acta Crystallographica Section E: Structure Reports Online 66 (3), o597-o597, 2010
12010
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