| Crucial role of protein flexibility in formation of a stable reaction transition state in an α-amylase catalysis T Kosugi, S Hayashi Journal of the American Chemical Society 134 (16), 7045-7055, 2012 | 57 | 2012 |
| Theoretical Study on Excited States of Bacteriochlorophyll a in Solutions with Density Functional Assessment M Higashi, T Kosugi, S Hayashi, S Saito The Journal of Physical Chemistry B 118 (37), 10906-10918, 2014 | 49 | 2014 |
| QM/MM reweighting free energy SCF for geometry optimization on extensive free energy surface of enzymatic reaction T Kosugi, S Hayashi Journal of Chemical Theory and Computation 8 (1), 322-334, 2012 | 46 | 2012 |
| Robust folding of a de novo designed ideal protein even with most of the core mutated to valine R Koga, M Yamamoto, T Kosugi, N Kobayashi, T Sugiki, T Fujiwara, ... Proceedings of the National Academy of Sciences 117 (49), 31149-31156, 2020 | 30 | 2020 |
| QM/MM geometry optimization on extensive free-Energy surfaces for examination of enzymatic reactions and design of novel functional properties of proteins S Hayashi, Y Uchida, T Hasegawa, M Higashi, T Kosugi, M Kamiya Annual Review of Physical Chemistry 68 (1), 135-154, 2017 | 18 | 2017 |
| ShadowR: a novel chromoprotein with reduced non-specific binding and improved expression in living cells H Murakoshi, H Horiuchi, T Kosugi, M Onda, A Sato, N Koga, J Nabekura Scientific Reports 9 (1), 12072, 2019 | 12 | 2019 |
| Local entropy difference upon a substrate binding of a psychrophilic α-amylase and a mesophilic homologue T Kosugi, S Hayashi Chemical Physics Letters 501 (4-6), 517-522, 2011 | 6 | 2011 |
| Design of allosteric sites into rotary motor V1-ATPase by restoring lost function of pseudo-active sites T Kosugi, T Iida, M Tanabe, R Iino, N Koga Nature Chemistry 15 (11), 1591-1598, 2023 | 5 | 2023 |
| Binding free energy calculations of adenosine deaminase inhibitor and the effect of methyl substitution in inhibitors T Kosugi, I Nakanishi, K Kitaura Journal of chemical information and modeling 49 (3), 615-622, 2009 | 5 | 2009 |
| Design of complicated all-α protein structures K Sakuma, N Kobayashi, T Sugiki, T Nagashima, T Fujiwara, K Suzuki, ... Nature Structural & Molecular Biology 31 (2), 275-282, 2024 | 4 | 2024 |
| State-Targeting Stabilization of Adenosine A2A Receptor by Fusing a Custom-Made De Novo Designed α-Helical Protein M Mitsumoto, K Sugaya, K Kazama, R Nakano, T Kosugi, T Murata, ... International Journal of Molecular Sciences 22 (23), 12906, 2021 | 3 | 2021 |
| De Novo Design of Allosteric Control into Rotary Motor V1-ATPase by Restoring Lost Function T Kosugi, T Iida, M Tanabe, R Iino, N Koga bioRxiv, 2020.09. 09.288571, 2020 | 1 | 2020 |
| Structure-based engineering of Tor complexes reveals that two types of yeast TORC1 produce distinct phenotypes Y Kamada, C Umeda, Y Mukai, H Ohtsuka, Y Otsubo, A Yamashita, ... Journal of Cell Science 137 (4), 2024 | | 2024 |
| Structure-based engineering of Tor complexes uncovers different roles of two types of yeast TORC1s Y Kamada, C Umeda, Y Mukai, H Ohtsuka, Y Otsubo, A Yamashita, ... bioRxiv, 2023.07. 04.547620, 2023 | | 2023 |
| Tackle “Molecular Engine” by early-career researchers A Otomo, T Kosugi Biophysics and Physicobiology 19, e190039, 2022 | | 2022 |
| Uncovering the design principles of supramolecular assemblies through manipulation of the structures, dynamics, and functions M Miyazaki, T Kosugi Biophysics and Physicobiology 19, e190031, 2022 | | 2022 |
| Operation and Design Principles of Biological Molecular Machines T Kosugi, T Iida, M Tanabe, R Iino, N Koga J. Biol. Chem 294, 17017-17030, 2019 | | 2019 |
| Theoretical Study of Structural Flexibility and Enzymatic Activity of a Psycrophilic α-Amylase T Kosugi 京都大学 (Kyoto University), 2012 | | 2012 |
| 機能を持った理想的な蛋白質の理論設計 B David, T Kosugi, N Koga, R Tatsumi-Koga, D Baker | | |
