| The CDK4/6 inhibitor abemaciclib induces a T cell inflamed tumor microenvironment and enhances the efficacy of PD-L1 checkpoint blockade DA Schaer, RP Beckmann, JA Dempsey, L Huber, A Forest, N Amaladas, ... Cell reports 22 (11), 2978-2994, 2018 | 379 | 2018 |
| Phosphorylation of eIF2 directs ATF5 translational control in response to diverse stress conditions D Zhou, LR Palam, L Jiang, J Narasimhan, KA Staschke, RC Wek Journal of Biological Chemistry 283 (11), 7064-7073, 2008 | 347 | 2008 |
| A critical role for IRAK4 kinase activity in Toll-like receptor–mediated innate immunity TW Kim, K Staschke, K Bulek, J Yao, K Peters, KH Oh, Y Vandenburg, ... The Journal of experimental medicine 204 (5), 1025-1036, 2007 | 335 | 2007 |
| Phosphorylation of hepatitis C virus NS5A nonstructural protein: a new paradigm for phosphorylation-dependent viral RNA replication? Y Huang, K Staschke, R De Francesco, SL Tan Virology 364 (1), 1-9, 2007 | 200 | 2007 |
| Oligomerization and cooperative RNA synthesis activity of hepatitis C virus RNA-dependent RNA polymerase QM Wang, MA Hockman, K Staschke, RB Johnson, KA Case, J Lu, ... Journal of virology 76 (8), 3865-3872, 2002 | 177 | 2002 |
| Identification of druggable cancer driver genes amplified across TCGA datasets Y Chen, J McGee, X Chen, TN Doman, X Gong, Y Zhang, N Hamm, X Ma, ... PloS one 9 (5), e98293, 2014 | 163 | 2014 |
| Molecular basis for the resistance of influenza viruses to 4-guanidino-Neu5Ac2en KA STASCHKE, JM COLACINO, AJ BAXTER, GM AIR, A BANSAL, ... Virology 214 (2), 642-646, 1995 | 147 | 1995 |
| Integration of general amino acid control and target of rapamycin (TOR) regulatory pathways in nitrogen assimilation in yeast KA Staschke, S Dey, JM Zaborske, LR Palam, JN McClintick, T Pan, ... Journal of Biological Chemistry 285 (22), 16893-16911, 2010 | 146 | 2010 |
| Dimerization is required for activation of eIF2 kinase Gcn2 in response to diverse environmental stress conditions J Narasimhan, KA Staschke, RC Wek Journal of Biological Chemistry 279 (22), 22820-22832, 2004 | 112 | 2004 |
| HCV NS5A: a multifunctional regulator of cellular pathways and virus replication Y He, KA Staschke, SL Tan Hepatitis C viruses: genomes and molecular biology, 2006 | 108 | 2006 |
| Mechanism of activation of the double‐stranded‐RNA‐dependent protein kinase, PKR: role of dimerization and cellular localization in the stimulation of PKR phosphorylation of … KM Vattem, KA Staschke, RC Wek European journal of biochemistry 268 (13), 3674-3684, 2001 | 93 | 2001 |
| IRAK4 kinase activity is required for Th17 differentiation and Th17-mediated disease KA Staschke, S Dong, J Saha, J Zhao, NA Brooks, DL Hepburn, J Xia, ... The Journal of Immunology 183 (1), 568-577, 2009 | 89 | 2009 |
| A Rab-GAP TBC domain protein binds hepatitis C virus NS5A and mediates viral replication EH Sklan, K Staschke, TM Oakes, M Elazar, M Winters, B Aroeti, T Danieli, ... Journal of virology 81 (20), 11096-11105, 2007 | 87 | 2007 |
| Genetic ablation of IRAK4 kinase activity inhibits vascular lesion formation M Rekhter, K Staschke, T Estridge, P Rutherford, N Jackson, ... Biochemical and biophysical research communications 367 (3), 642-648, 2008 | 74 | 2008 |
| Inhibition of influenza virus hemagglutinin-mediated membrane fusion by a compound related to podocarpic acid KA Staschke, SD Hatch, JC Tang, WJ Hornback, JE Munroe, JM Colacino, ... Virology 248 (2), 264-274, 1998 | 74 | 1998 |
| The critical role of IL-1 receptor-associated kinase 4-mediated NF-κB activation in modified low-density lipoprotein-induced inflammatory gene expression and atherosclerosis TW Kim, M Febbraio, P Robinet, B DuGar, D Greene, A Cerny, E Latz, ... The Journal of Immunology 186 (5), 2871-2880, 2011 | 64 | 2011 |
| The identification and development of antiviral agents for the treatment of chronic hepatitis B virus infection PN Kaul, G Edwards, AH Weston, M Rohmer, RW Rockhold, TD Johnson, ... Progress in drug research, 259-322, 1998 | 64 | 1998 |
| Comparative characterization of two DEAD-box RNA helicases in superfamily II: human translation-initiation factor 4A and hepatitis C virus non-structural protein 3 (NS3) helicase RB JOHNSON, SUN Xin-Lai, KA STASCHKE, J COLACINO, QM WANG Biochemical Journal 363 (1), 147-155, 2002 | 62 | 2002 |
| Pellino 3b negatively regulates interleukin-1-induced TAK1-dependent NFκB activation H Xiao, W Qian, K Staschke, Y Qian, G Cui, L Deng, M Ehsani, X Wang, ... Journal of biological chemistry 283 (21), 14654-14664, 2008 | 55 | 2008 |
| PERK is a haploinsufficient tumor suppressor: gene dose determines tumor-suppressive versus tumor promoting properties of PERK in melanoma D Pytel, Y Gao, K Mackiewicz, YV Katlinskaya, KA Staschke, ... PLoS genetics 12 (12), e1006518, 2016 | 51 | 2016 |
