Structural basis of membrane disruption and cellular toxicity by α-synuclein oligomers G Fusco, SW Chen, PTF Williamson, R Cascella, M Perni, JA Jarvis, ... Science 358 (6369), 1440-1443, 2017 | 604 | 2017 |
A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity M Perni, C Galvagnion, A Maltsev, G Meisl, MBD Müller, PK Challa, ... Proceedings of the National Academy of Sciences 114 (6), E1009-E1017, 2017 | 308 | 2017 |
An anticancer drug suppresses the primary nucleation reaction that initiates the production of the toxic Aβ42 aggregates linked with Alzheimer’s disease J Habchi, P Arosio, M Perni, AR Costa, M Yagi-Utsumi, P Joshi, S Chia, ... Science advances 2 (2), e1501244, 2016 | 223 | 2016 |
Systematic development of small molecules to inhibit specific microscopic steps of Aβ42 aggregation in Alzheimer’s disease J Habchi, S Chia, R Limbocker, B Mannini, M Ahn, M Perni, O Hansson, ... Proceedings of the National Academy of Sciences 114 (2), E200-E208, 2017 | 212 | 2017 |
Selective targeting of primary and secondary nucleation pathways in Aβ42 aggregation using a rational antibody scanning method FA Aprile, P Sormanni, M Perni, P Arosio, S Linse, TPJ Knowles, ... Science advances 3 (6), e1700488, 2017 | 146 | 2017 |
Trodusquemine enhances Aβ42 aggregation but suppresses its toxicity by displacing oligomers from cell membranes R Limbocker, S Chia, FS Ruggeri, M Perni, R Cascella, GT Heller, G Meisl, ... Nature communications 10 (1), 225, 2019 | 135 | 2019 |
Small-molecule sequestration of amyloid-β as a drug discovery strategy for Alzheimer’s disease GT Heller, FA Aprile, TCT Michaels, R Limbocker, M Perni, FS Ruggeri, ... Science advances 6 (45), eabb5924, 2020 | 108 | 2020 |
Multistep Inhibition of α-Synuclein Aggregation and Toxicity in Vitro and in Vivo by Trodusquemine M Perni, P Flagmeier, R Limbocker, R Cascella, FA Aprile, C Galvagnion, ... ACS chemical biology 13 (8), 2308-2319, 2018 | 108 | 2018 |
TDP-43 inclusion bodies formed in bacteria are structurally amorphous, non-amyloid and inherently toxic to neuroblastoma cells C Capitini, S Conti, M Perni, F Guidi, R Cascella, A De Poli, A Penco, ... PloS one 9 (1), e86720, 2014 | 84 | 2014 |
Rational design of a conformation-specific antibody for the quantification of Aβ oligomers FA Aprile, P Sormanni, M Podpolny, S Chhangur, LM Needham, ... Proceedings of the National Academy of Sciences 117 (24), 13509-13518, 2020 | 75 | 2020 |
Massively parallel C. elegans tracking provides multi-dimensional fingerprints for phenotypic discovery M Perni, PK Challa, JB Kirkegaard, R Limbocker, M Koopman, ... Journal of neuroscience methods 306, 57-67, 2018 | 59 | 2018 |
Cytosolic aggregation of mitochondrial proteins disrupts cellular homeostasis by stimulating the aggregation of other proteins U Nowicka, P Chroscicki, K Stroobants, M Sladowska, M Turek, ... Elife 10, e65484, 2021 | 58 | 2021 |
Trodusquemine displaces protein misfolded oligomers from cell membranes and abrogates their cytotoxicity through a generic mechanism R Limbocker, B Mannini, FS Ruggeri, R Cascella, CK Xu, M Perni, S Chia, ... Communications biology 3 (1), 435, 2020 | 53 | 2020 |
Stabilization and Characterization of Cytotoxic Aβ40 Oligomers Isolated from an Aggregation Reaction in the Presence of Zinc Ions B Mannini, J Habchi, S Chia, FS Ruggeri, M Perni, TPJ Knowles, ... ACS chemical neuroscience 9 (12), 2959-2971, 2018 | 47 | 2018 |
Probing the origin of the toxicity of oligomeric aggregates of α-synuclein with antibodies R Cascella, M Perni, SW Chen, G Fusco, C Cecchi, M Vendruscolo, ... ACS chemical biology 14 (6), 1352-1362, 2019 | 42 | 2019 |
Squalamine and its derivatives modulate the aggregation of amyloid-β and α-synuclein and suppress the toxicity of their oligomers R Limbocker, R Staats, S Chia, FS Ruggeri, B Mannini, CK Xu, M Perni, ... Frontiers in Neuroscience 15, 680026, 2021 | 40 | 2021 |
A dopamine metabolite stabilizes neurotoxic amyloid-β oligomers R Cataldi, S Chia, K Pisani, FS Ruggeri, CK Xu, T Šneideris, M Perni, ... Communications biology 4 (1), 19, 2021 | 34 | 2021 |
Assessing motor-related phenotypes of Caenorhabditis elegans with the wide field-of-view nematode tracking platform M Koopman, Q Peter, RI Seinstra, M Perni, M Vendruscolo, CM Dobson, ... Nature protocols 15 (6), 2071-2106, 2020 | 33 | 2020 |
Fast Fluorescence Lifetime Imaging Reveals the Aggregation Processes of α-Synuclein and Polyglutamine in Aging Caenorhabditis elegans RF Laine, T Sinnige, KY Ma, AJ Haack, C Poudel, P Gaida, N Curry, ... ACS chemical biology 14 (7), 1628-1636, 2019 | 27 | 2019 |
Delivery of Native Proteins into C. elegans Using a Transduction Protocol Based on Lipid Vesicles M Perni, FA Aprile, S Casford, B Mannini, P Sormanni, CM Dobson, ... Scientific Reports 7 (1), 15045, 2017 | 21 | 2017 |