| Ribosome display efficiently selects and evolves high-affinity antibodies in vitro from immune libraries J Hanes, L Jermutus, S Weber-Bornhauser, HR Bosshard, A Plückthun Proceedings of the National Academy of Sciences 95 (24), 14130-14135, 1998 | 487 | 1998 |
| Unbinding forces of single antibody-antigen complexes correlate with their thermal dissociation rates F Schwesinger, R Ros, T Strunz, D Anselmetti, HJ Güntherodt, ... Proceedings of the National Academy of Sciences 97 (18), 9972-9977, 2000 | 418 | 2000 |
| Ribosome display: an in vitro method for selection and evolution of antibodies from libraries C Schaffitzel, J Hanes, L Jermutus, A Plückthun Journal of immunological methods 231 (1-2), 119-135, 1999 | 384 | 1999 |
| Tailoring in vitro evolution for protein affinity or stability L Jermutus, A Honegger, F Schwesinger, J Hanes, A Plückthun Proceedings of the National Academy of Sciences 98 (1), 75-80, 2001 | 352 | 2001 |
| MEDI0382, a GLP-1 and glucagon receptor dual agonist, in obese or overweight patients with type 2 diabetes: a randomised, controlled, double-blind, ascending dose and phase 2a … P Ambery, VE Parker, M Stumvoll, MG Posch, T Heise, L Plum-Moerschel, ... The Lancet 391 (10140), 2607-2618, 2018 | 294 | 2018 |
| Challenges and opportunities for non-antibody scaffold drugs R Vazquez-Lombardi, TG Phan, C Zimmermann, D Lowe, L Jermutus, ... Drug discovery today 20 (10), 1271-1283, 2015 | 285 | 2015 |
| Recent advances in producing and selecting functional proteins by using cell-free translation L Jermutus, LA Ryabova, A Plückthun Current Opinion in Biotechnology 9 (5), 534-548, 1998 | 275 | 1998 |
| LEAP2 is an endogenous antagonist of the ghrelin receptor X Ge, H Yang, MA Bednarek, H Galon-Tilleman, P Chen, M Chen, ... Cell metabolism 27 (2), 461-469. e6, 2018 | 271 | 2018 |
| Concepts in antibody phage display S Carmen, L Jermutus Briefings in Functional Genomics 1 (2), 189-203, 2002 | 257 | 2002 |
| Robust anti‐obesity and metabolic effects of a dual GLP‐1/glucagon receptor peptide agonist in rodents and non‐human primates SJ Henderson, A Konkar, DC Hornigold, JL Trevaskis, R Jackson, ... Diabetes, Obesity and Metabolism 18 (12), 1176-1190, 2016 | 233 | 2016 |
| Aggregation, stability, and formulation of human antibody therapeutics D Lowe, K Dudgeon, R Rouet, P Schofield, L Jermutus, D Christ Advances in protein chemistry and structural biology 84, 41-61, 2011 | 200 | 2011 |
| Effects of cotadutide on metabolic and hepatic parameters in adults with overweight or obesity and type 2 diabetes: a 54-week randomized phase 2b study R Nahra, T Wang, KM Gadde, J Oscarsson, M Stumvoll, L Jermutus, ... Diabetes care 44 (6), 1433-1442, 2021 | 198 | 2021 |
| Identification of broadly protective human antibodies to Pseudomonas aeruginosa exopolysaccharide Psl by phenotypic screening A Digiandomenico, P Warrener, M Hamilton, S Guillard, P Ravn, R Minter, ... Journal of Experimental Medicine 209 (7), 1273-1287, 2012 | 192 | 2012 |
| Harnessing phage and ribosome display for antibody optimisation P Dufner, L Jermutus, RR Minter Trends in biotechnology 24 (11), 523-529, 2006 | 187 | 2006 |
| Resolution of NASH and hepatic fibrosis by the GLP-1R and GCGR dual-agonist cotadutide via modulating mitochondrial function and lipogenesis ML Boland, RC Laker, K Mather, A Nawrocki, S Oldham, BB Boland, ... Nature metabolism 2 (5), 413-431, 2020 | 176 | 2020 |
| [24] Selecting and evolving functional proteins in vitro by ribosome display J Hanes, L Jermutus, A Plückthun Methods in enzymology 328, 404-430, 2000 | 160 | 2000 |
| Selection of hapten-specific single-domain antibodies from a non-immunized llama ribosome display library KYF Yau, MAT Groves, S Li, C Sheedy, H Lee, J Tanha, CR MacKenzie, ... Journal of immunological methods 281 (1-2), 161-175, 2003 | 152 | 2003 |
| In vitro selection and evolution of proteins A Plückthun, C Schaffitzel, J Hanes, L Jermutus Advances in protein chemistry 55, 367-403, 2001 | 138 | 2001 |
| Probing a protein–protein interaction by in vitro evolution G Thom, AC Cockroft, AG Buchanan, C Joberty Candotti, ES Cohen, ... Proceedings of the National Academy of Sciences 103 (20), 7619-7624, 2006 | 115 | 2006 |
| Affinity maturation of a VHH by mutational hotspot randomization KYF Yau, G Dubuc, S Li, T Hirama, CR MacKenzie, L Jermutus, JC Hall, ... Journal of immunological methods 297 (1-2), 213-224, 2005 | 113 | 2005 |
Andreas PluckthunBiochemisches Institut, Universität Zürich在 bioc.uzh.ch 的电子邮件经过验证
