Nicotinamide riboside augments the aged human skeletal muscle NAD+ metabolome and induces transcriptomic and anti-inflammatory signatures YS Elhassan, K Kluckova, RS Fletcher, MS Schmidt, A Garten, CL Doig, ... Cell reports 28 (7), 1717-1728. e6, 2019 | 334 | 2019 |
A switch in hepatic cortisol metabolism across the spectrum of non alcoholic fatty liver disease A Ahmed, E Rabbitt, T Brady, C Brown, P Guest, IJ Bujalska, C Doig, ... PloS one 7 (2), e29531, 2012 | 133 | 2012 |
Nicotinamide riboside kinases display redundancy in mediating nicotinamide mononucleotide and nicotinamide riboside metabolism in skeletal muscle cells RS Fletcher, J Ratajczak, CL Doig, LA Oakey, R Callingham, GDS Xavier, ... Molecular metabolism 6 (8), 819-832, 2017 | 108 | 2017 |
Epigenetic control of a VDR-governed feed-forward loop that regulates p21 ( waf1/cip1 ) expression and function in … JL Thorne, O Maguire, CL Doig, S Battaglia, L Fehr, LE Sucheston, ... Nucleic acids research 39 (6), 2045-2056, 2011 | 78 | 2011 |
Recruitment of NCOR1 to VDR target genes is enhanced in prostate cancer cells and associates with altered DNA methylation patterns CL Doig, PK Singh, VK Dhiman, JL Thorne, S Battaglia, M Sobolewski, ... Carcinogenesis 34 (2), 248-256, 2013 | 73 | 2013 |
Elevated NCOR1 disrupts PPARα/γ signaling in prostate cancer and forms a targetable epigenetic lesion S Battaglia, O Maguire, JL Thorne, LB Hornung, CL Doig, S Liu, ... Carcinogenesis 31 (9), 1650-1660, 2010 | 72 | 2010 |
Glucocorticoids reprogram β-cell signaling to preserve insulin secretion NHF Fine, CL Doig, YS Elhassan, NC Vierra, P Marchetti, M Bugliani, ... Diabetes 67 (2), 278-290, 2018 | 66 | 2018 |
Pituitary tumor transforming gene binding factor: a new gene in breast cancer RJ Watkins, ML Read, VE Smith, N Sharma, GM Reynolds, L Buckley, ... Cancer Research 70 (9), 3739-3749, 2010 | 61 | 2010 |
11β-HSD1 Modulates the Set Point of Brown Adipose Tissue Response to Glucocorticoids in Male Mice CL Doig, RS Fletcher, SA Morgan, EL McCabe, DP Larner, JW Tomlinson, ... Endocrinology 158 (6), 1964-1976, 2017 | 38 | 2017 |
Glucocorticoids and 11β-HSD1 are major regulators of intramyocellular protein metabolism SA Morgan, ZK Hassan-Smith, CL Doig, M Sherlock, PM Stewart, ... The Journal of Endocrinology 229 (3), 277, 2016 | 34 | 2016 |
11β-HSD1 plays a critical role in trabecular bone loss associated with systemic glucocorticoid therapy CG Fenton, CL Doig, S Fareed, A Naylor, AP Morrell, O Addison, ... Arthritis Research & Therapy 21, 1-10, 2019 | 33 | 2019 |
11β‐Hydroxysteroid dehydrogenase type 1 within muscle protects against the adverse effects of local inflammation RS Hardy, CL Doig, Z Hussain, M O'Leary, SA Morgan, MJ Pearson, ... The Journal of pathology 240 (4), 472-483, 2016 | 33 | 2016 |
Nicotinamide nucleotide transhydrogenase as a novel treatment target in adrenocortical carcinoma V Chortis, AE Taylor, CL Doig, MD Walsh, E Meimaridou, C Jenkinson, ... Endocrinology 159 (8), 2836-2849, 2018 | 31 | 2018 |
Male 11β-HSD1 knockout mice fed trans-fats and fructose are not protected from metabolic syndrome or nonalcoholic fatty liver disease DP Larner, SA Morgan, LL Gathercole, CL Doig, P Guest, C Weston, ... Endocrinology 157 (9), 3493-3504, 2016 | 27 | 2016 |
Metabolic tracing reveals novel adaptations to skeletal muscle cell energy production pathways in response to NAD+ depletion LA Oakey, RS Fletcher, YS Elhassan, DM Cartwright, CL Doig, A Garten, ... Wellcome open research 3, 2018 | 26 | 2018 |
Physiological roles of carnosine in myocardial function and health JV Creighton, L de Souza Gonçalves, GG Artioli, D Tan, KJ Elliott-Sale, ... Advances in Nutrition 13 (5), 1914-1929, 2022 | 23 | 2022 |
Knockdown of AKR1C3 exposes a potential epigenetic susceptibility in prostate cancer cells CL Doig, S Battaglia, FL Khanim, CM Bunce, MJ Campbell The Journal of steroid biochemistry and molecular biology 155, 47-55, 2016 | 23 | 2016 |
Epigenetic distortion to VDR transcriptional regulation in prostate cancer cells PK Singh, CL Doig, VK Dhiman, BM Turner, DJ Smiraglia, MJ Campbell The Journal of steroid biochemistry and molecular biology 136, 258-263, 2013 | 22 | 2013 |
NAD+ Degrading Enzymes, Evidence for Roles During Infection A Tan, CL Doig Frontiers in Molecular Biosciences 8, 697359, 2021 | 16 | 2021 |
Carnosine protects stimulus-secretion coupling through prevention of protein carbonyl adduction events in cells under metabolic stress MP Billacura, K Hanna, DJ Boocock, C Coveney, AK Miles, GA Foulds, ... Free Radical Biology and Medicine 175, 65-79, 2021 | 14 | 2021 |