| Modeling sporadic ALS in iPSC-derived motor neurons identifies a potential therapeutic agent K Fujimori, M Ishikawa, A Otomo, N Atsuta, R Nakamura, T Akiyama, ... Nature medicine 24 (10), 1579-1589, 2018 | 400 | 2018 |
| TDP-43 represses cryptic exon inclusion in the FTD–ALS gene UNC13A XR Ma, M Prudencio, Y Koike, SC Vatsavayai, G Kim, F Harbinski, ... Nature 603 (7899), 124-130, 2022 | 293 | 2022 |
| Establishment of in vitro FUS-associated familial amyotrophic lateral sclerosis model using human induced pluripotent stem cells N Ichiyanagi, K Fujimori, M Yano, C Ishihara-Fujisaki, T Sone, T Akiyama, ... Stem cell reports 6 (4), 496-510, 2016 | 97 | 2016 |
| FALS with FUS mutation in Japan, with early onset, rapid progress and basophilic inclusion N Suzuki, M Aoki, H Warita, M Kato, H Mizuno, N Shimakura, T Akiyama, ... Journal of human genetics 55 (4), 252-254, 2010 | 81 | 2010 |
| Aberrant axon branching via Fos-B dysregulation in FUS-ALS motor neurons T Akiyama, N Suzuki, M Ishikawa, K Fujimori, T Sone, J Kawada, ... EBioMedicine 45, 362-378, 2019 | 66 | 2019 |
| Comprehensive targeted next-generation sequencing in Japanese familial amyotrophic lateral sclerosis A Nishiyama, T Niihori, H Warita, R Izumi, T Akiyama, M Kato, N Suzuki, ... Neurobiology of Aging 53, 194. e1-194. e8, 2017 | 57 | 2017 |
| Omics approach to axonal dysfunction of motor neurons in amyotrophic lateral sclerosis (ALS) N Suzuki, T Akiyama, H Warita, M Aoki Frontiers in Neuroscience 14, 194, 2020 | 42 | 2020 |
| Neuronal activity in the primate dorsomedial prefrontal cortex contributes to strategic selection of response tactics Y Matsuzaka, T Akiyama, J Tanji, H Mushiake Proceedings of the National Academy of Sciences 109 (12), 4633-4638, 2012 | 34 | 2012 |
| Genotype–phenotype relationships in familial amyotrophic lateral sclerosis with FUS/TLS mutations in Japan T Akiyama, H Warita, M Kato, A Nishiyama, R Izumi, C Ikeda, M Kamada, ... Muscle & Nerve 54 (3), 398-404, 2016 | 28 | 2016 |
| TARDBP p. G376D mutation, found in rapid progressive familial ALS, induces mislocalization of TDP-43 S Mitsuzawa, T Akiyama, A Nishiyama, N Suzuki, M Kato, H Warita, ... Eneurologicalsci 11, 20, 2018 | 26 | 2018 |
| Continuous administration of poloxamer 188 reduces overload-induced muscular atrophy in dysferlin-deficient SJL mice N Suzuki, T Akiyama, T Takahashi, H Komuro, H Warita, M Tateyama, ... Neuroscience Research 72 (2), 181-186, 2012 | 26 | 2012 |
| Extracellular α‐synuclein enters dopaminergic cells by modulating flotillin‐1–assisted dopamine transporter endocytosis J Kobayashi, T Hasegawa, N Sugeno, S Yoshida, T Akiyama, K Fujimori, ... The FASEB Journal 33 (9), 10240-10256, 2019 | 23 | 2019 |
| An amyotrophic lateral sclerosis-associated mutant of C21ORF2 is stabilized by NEK1-mediated hyperphosphorylation and the inability to bind FBXO3 Y Watanabe, T Nakagawa, T Akiyama, M Nakagawa, N Suzuki, H Warita, ... IScience 23 (9), 2020 | 22 | 2020 |
| Aberrant astrocytic expression of chondroitin sulfate proteoglycan receptors in a rat model of amyotrophic lateral sclerosis T Shijo, H Warita, N Suzuki, Y Kitajima, K Ikeda, T Akiyama, H Ono, ... Journal of Neuroscience Research 96 (2), 222-233, 2018 | 22 | 2018 |
| Genome-wide CRISPR screen reveals v-ATPase as a drug target to lower levels of ALS protein ataxin-2 G Kim, L Nakayama, JA Blum, T Akiyama, S Boeynaems, M Chakraborty, ... Cell reports 41 (4), 2022 | 16 | 2022 |
| AMPK complex activation promotes sarcolemmal repair in dysferlinopathy H Ono, N Suzuki, S Kanno, G Kawahara, R Izumi, T Takahashi, Y Kitajima, ... Molecular Therapy 28 (4), 1133-1153, 2020 | 16 | 2020 |
| Antagonizing bone morphogenetic protein 4 attenuates disease progression in a rat model of amyotrophic lateral sclerosis T Shijo, H Warita, N Suzuki, K Ikeda, S Mitsuzawa, T Akiyama, H Ono, ... Experimental Neurology 307, 164-179, 2018 | 16 | 2018 |
| Cracking the cryptic code in amyotrophic lateral sclerosis and frontotemporal dementia: Towards therapeutic targets and biomarkers T Akiyama, Y Koike, L Petrucelli, AD Gitler Clinical and Translational Medicine 12 (5), e818, 2022 | 15 | 2022 |
| Reduced PHOX2B stability causes axonal growth impairment in motor neurons with TARDBP mutations S Mitsuzawa, N Suzuki, T Akiyama, M Ishikawa, T Sone, J Kawada, ... Stem cell reports 16 (6), 1527-1541, 2021 | 12 | 2021 |
| Identification of hub molecules of FUS-ALS by Bayesian gene regulatory network analysis of iPSC model: iBRN M Nogami, M Ishikawa, A Doi, O Sano, T Sone, T Akiyama, M Aoki, ... Neurobiology of Disease 155, 105364, 2021 | 9 | 2021 |
