structure-based design, synthesis and preliminary evaluation of selective inhibitors of dihydrofolate reductase from Mycobacterium Tuberculosis. Bioorg. Med, Chem., 15, 4552 – 4576 MHRI El-Hamamsy, AW Smith, AS Thompson, MD Threadgill | 71* | 2007 |
Discovery of new carbonic anhydrase IX inhibitors as anticancer agents by toning the hydrophobic and hydrophilic rims of the active site to encounter the dual-tail approach HO Tawfik, A Petreni, CT Supuran, MH El-Hamamsy European journal of medicinal chemistry 232, 114190, 2022 | 37 | 2022 |
1,4-Dihydropyridine Calcium Channel Blockers: Homology Modeling of the Receptor and Assessment of Structure Activity Relationship TFEM Moataz A. Shaldam, Mervat H. Elhamamsy, Eman A. Esmat ISRN Medicinal Chemistry 2014, 14, 2014 | 28* | 2014 |
Design, synthesis, and bioactivity of dihydropyrimidine derivatives as kinesin spindle protein inhibitors HO Tawfik, TF El-Moselhy, NS El-Din, MH El-Hamamsy Bioorganic & Medicinal Chemistry 27 (23), 115126, 2019 | 23 | 2019 |
Synthesis, evaluation and docking study of 1, 3, 5-triazine derivatives as cytotoxic agents against lung cancer MF Balahaa, MH El-Hamamsyb, NAS El-Dinc, NA El-Mahdyd Journal of Applied Pharmaceutical Science 6 (4), 028-045, 2016 | 22 | 2016 |
Dependence on linkers’ flexibility designed for benzenesulfonamides targeting discovery of novel hCA IX inhibitors as potent anticancer agents HO Tawfik, A Belal, MAS Abourehab, A Angeli, A Bonardi, CT Supuran, ... Journal of Enzyme Inhibition and Medicinal Chemistry 37 (1), 2765-2785, 2022 | 16 | 2022 |
Design, synthesis, and molecular docking study of new monastrol analogues as kinesin spindle protein inhibitors MH El‐Hamamsy, NA Sharafeldin, TF El‐Moselhy, HO Tawfik Archiv der Pharmazie 353 (8), 2000060, 2020 | 15 | 2020 |
New genetic bomb trigger: Design, synthesis, molecular dynamics simulation, and biological evaluation of novel BIBR1532-related analogs targeting telomerase against non-small … HO Tawfik, AA El-Hamaky, EA El-Bastawissy, KA Shcherbakov, ... Pharmaceuticals 15 (4), 481, 2022 | 14 | 2022 |
Synthesis and anticancer activity of new benzensulfonamides incorporating s-triazines as cyclic linkers for inhibition of carbonic anhydrase IX AI Zain-Alabdeen, TF El-Moselhy, N Sharafeldin, A Angeli, CT Supuran, ... Scientific Reports 12 (1), 16756, 2022 | 13 | 2022 |
Discovery of new symmetrical and asymmetrical nitrile-containing 1,4-dihydropyridine derivatives as dual kinases and P-glycoprotein inhibitors: synthesis, in vitro assays, and … MH Saad, TF El-Moselhy, N S, El-Din, ABM Mehany, A Belal, ... Journal of Enzyme Inhibition and Medicinal Chemistry 37 (1), 2489-2511, 2022 | 8 | 2022 |
Synthesis, evaluation of pharmacological activity, and molecular docking of 1, 4-dihydropyridines as calcium antagonists MA Shaldam, MH El-Hamamsy, DO Saleh, TF El-Moselhy Chemical and Pharmaceutical Bulletin 64 (4), 297-304, 2016 | 7 | 2016 |
Discovery of novel enasidenib analogues targeting inhibition of mutant isocitrate dehydrogenase 2 as antileukaemic agents AF Khalil, TF El-Moselhy, EA El-Bastawissy, R Abdelhady, NS Younis, ... Journal of Enzyme Inhibition and Medicinal Chemistry 38 (1), 2157411, 2023 | 6 | 2023 |
Accessing the anti-proliferating activity of tankyrase-2 inhibitors via 2d, 3d-QSAR and molecular docking: assessment of structure activity relationships MH El-Hamamsy Journal of Applied Pharmaceutical Science 7 (12), 014-027, 2017 | 4 | 2017 |
Factorial analysis optimization of memantine hydrochloride spectrofluorimetric quantitation via derivatization withoff-phthalaldehyde in the absence of thiol MH El-Hamamsy Journal of Innovations in Pharmaceutical and Biological Science 4 (4), 176-184, 2017 | 4 | 2017 |
El-Din, NAESS Exploring the cytotoxicity of 1, 3, 5-triazines and triazine analogs against lung cancer by QSAR study using genetic function approximation MF Balaha, MH El-Hamamsy Pharma Chem 8 (3), 180-188, 2016 | 4 | 2016 |
Recruitment of hexahydroquinoline as anticancer scaffold targeting inhibition of wild and mutants EGFR (EGFRWT, EGFRT790M, and EGFRL858R) MG Abo Al-Hamd, HO Tawfik, O Abdullah, K Yamaguchi, M Sugiura, ... Journal of Enzyme Inhibition and Medicinal Chemistry 38 (1), 2241674, 2023 | 3 | 2023 |
Corrigendum to" Design, synthesis, and bioactivity of dihydropyrimidine derivatives as kinesin spindle protein inhibitors"[Bioorg. Med. Chem. 27 (2019) 115126]. HO Tawfik, TF El-Moselhy, NS El-Din, MH El-Hamamsy Bioorganic & medicinal chemistry 28 (19), 115687-115687, 2020 | 1 | 2020 |
Design, synthesis and biological evaluation of 1, 3, 5-triazine derivatives as potential inhibitors of dihydrofolate reductase M El-Hamamsy, N El-Mahdy Life Sci J 11 (11), 2014 | 1 | 2014 |
Potential antimycobacterial agent targeting dihydrofolate reductase MHRI El-Hamamsy PQDT-UK & Ireland, 2005 | 1 | 2005 |
Rationale design of novel substituted 1, 3, 5-triazine candidates as dual IDH1 (R132H)/IDH2 (R140Q) inhibitors with high selectivity against acute myeloid leukemia: In vitro … HO Tawfik, MHA Mousa, MY Zaky, AM El-Dessouki, M Sharaky, ... Bioorganic Chemistry 149, 107483, 2024 | | 2024 |