LD Hub: a centralized database and web interface to perform LD score regression that maximizes the potential of summary level GWAS data for SNP heritability and genetic … J Zheng, AM Erzurumluoglu, BL Elsworth, JP Kemp, L Howe, PC Haycock, ... Bioinformatics 33 (2), 272-279, 2017 | 939 | 2017 |
Avoiding dynastic, assortative mating, and population stratification biases in Mendelian randomization through within-family analyses B Brumpton, E Sanderson, K Heilbron, FP Hartwig, S Harrison, GÅ Vie, ... Nature Communications 11 (1), 1-13, 2020 | 253 | 2020 |
Within-sibship genome-wide association analyses decrease bias in estimates of direct genetic effects LJ Howe, MG Nivard, TT Morris, AF Hansen, H Rasheed, Y Cho, ... Nature genetics 54 (5), 581-592, 2022 | 213 | 2022 |
UK phenomics platform for developing and validating electronic health record phenotypes: CALIBER S Denaxas, A Gonzalez-Izquierdo, K Direk, NK Fitzpatrick, G Fatemifar, ... Journal of the American Medical Informatics Association 26 (12), 1545-1559, 2019 | 177 | 2019 |
Within family Mendelian randomization studies NM Davies, LJ Howe, B Brumpton, A Havdahl, DM Evans, G Davey Smith Human molecular genetics 28 (R2), R170-R179, 2019 | 133 | 2019 |
Genome-wide analysis identifies novel susceptibility loci for myocardial infarction JA Hartiala, Y Han, Q Jia, JR Hilser, P Huang, J Gukasyan, ... European heart journal 42 (9), 919-933, 2021 | 130 | 2021 |
Facial genetics: a brief overview S Richmond, LJ Howe, S Lewis, E Stergiakouli, A Zhurov Frontiers in genetics 9, 462, 2018 | 127 | 2018 |
Is population structure in the genetic biobank era irrelevant, a challenge, or an opportunity? DJ Lawson, NM Davies, S Haworth, B Ashraf, L Howe, A Crawford, ... Human genetics 139 (1), 23-41, 2020 | 104 | 2020 |
Novel genetic loci affecting facial shape variation in humans Z Xiong, G Dankova, LJ Howe, MK Lee, PG Hysi, MA de Jong, G Zhu, ... Elife 8, e49898, 2019 | 73 | 2019 |
Genetic evidence for assortative mating on alcohol consumption in the UK Biobank LJ Howe, DJ Lawson, NM Davies, BS Pourcain, SJ Lewis, G Davey Smith, ... Nature Communications 10 (1), 1-10, 2019 | 67 | 2019 |
Investigating the shared genetics of non-syndromic cleft lip/palate and facial morphology LJ Howe, MK Lee, GC Sharp, G Davey Smith, B St Pourcain, JR Shaffer, ... PLoS Genetics 14 (8), e1007501, 2018 | 59 | 2018 |
Modeling assortative mating and genetic similarities between partners, siblings, and in-laws FA Torvik, EM Eilertsen, LJ Hannigan, R Cheesman, LJ Howe, P Magnus, ... Nature Communications 13 (1), 1-10, 2022 | 51 | 2022 |
A GWAS in Latin Americans identifies novel face shape loci, implicating VPS13B and a Denisovan introgressed region in facial variation B Bonfante, P Faux, N Navarro, J Mendoza-Revilla, M Dubied, C Montillot, ... Science Advances 7 (6), eabc6160, 2021 | 49 | 2021 |
Body mass index, body dissatisfaction and adolescent smoking initiation LJ Howe, L Trela-Larsen, M Taylor, J Heron, MR Munafò, AE Taylor Drug & Alcohol Dependence 178, 143-149, 2017 | 46 | 2017 |
Association of Chromosome 9p21 with subsequent coronary heart disease events: a GENIUS-CHD study of individual participant data RS Patel, AF Schmidt, V Tragante, RO McCubrey, MV Holmes, LJ Howe, ... Circulation: Genomic and Precision Medicine 12 (4), e002471, 2019 | 33 | 2019 |
Evidence for DNA methylation mediating genetic liability to non-syndromic cleft lip/palate LJ Howe, TG Richardson, R Arathimos, L Alvizi, MR Passos-Bueno, ... Epigenomics 11 (2), 133-145, 2019 | 31 | 2019 |
Cleft lip/palate and educational attainment: cause, consequence or correlation? A Mendelian randomization study C Dardani, LJ Howe, N Mukhopadhyay, E Stergiakouli, Y Wren, ... International journal of epidemiology 49 (4), 1282-1293, 2020 | 29 | 2020 |
Polygenic risk scores for coronary artery disease and subsequent event risk amongst established cases LJ Howe, F Dudbridge, AF Schmidt, C Finan, S Denaxas, FW Asselbergs, ... Human molecular genetics 29 (8), 1388-1395, 2020 | 29 | 2020 |
Subsequent event risk in individuals with established coronary heart disease: design and rationale of the GENIUS-CHD consortium RS Patel, V Tragante, AF Schmidt, RO McCubrey, MV Holmes, LJ Howe, ... Circulation: Genomic and Precision Medicine 12 (4), e002470, 2019 | 28 | 2019 |
Interpreting Mendelian randomization estimates of the effects of categorical exposures such as disease status and educational attainment LJ Howe, M Tudball, GD Smith, NM Davies International journal of epidemiology, 0 | 27* | |