关注
Laurence Howe
Laurence Howe
Associate Director, GSK
在 gsk.com 的电子邮件经过验证
标题
引用次数
引用次数
年份
LD Hub: a centralized database and web interface to perform LD score regression that maximizes the potential of summary level GWAS data for SNP heritability and genetic …
J Zheng, AM Erzurumluoglu, BL Elsworth, JP Kemp, L Howe, PC Haycock, ...
Bioinformatics 33 (2), 272-279, 2017
9392017
Avoiding dynastic, assortative mating, and population stratification biases in Mendelian randomization through within-family analyses
B Brumpton, E Sanderson, K Heilbron, FP Hartwig, S Harrison, GÅ Vie, ...
Nature Communications 11 (1), 1-13, 2020
2532020
Within-sibship genome-wide association analyses decrease bias in estimates of direct genetic effects
LJ Howe, MG Nivard, TT Morris, AF Hansen, H Rasheed, Y Cho, ...
Nature genetics 54 (5), 581-592, 2022
2132022
UK phenomics platform for developing and validating electronic health record phenotypes: CALIBER
S Denaxas, A Gonzalez-Izquierdo, K Direk, NK Fitzpatrick, G Fatemifar, ...
Journal of the American Medical Informatics Association 26 (12), 1545-1559, 2019
1772019
Within family Mendelian randomization studies
NM Davies, LJ Howe, B Brumpton, A Havdahl, DM Evans, G Davey Smith
Human molecular genetics 28 (R2), R170-R179, 2019
1332019
Genome-wide analysis identifies novel susceptibility loci for myocardial infarction
JA Hartiala, Y Han, Q Jia, JR Hilser, P Huang, J Gukasyan, ...
European heart journal 42 (9), 919-933, 2021
1302021
Facial genetics: a brief overview
S Richmond, LJ Howe, S Lewis, E Stergiakouli, A Zhurov
Frontiers in genetics 9, 462, 2018
1272018
Is population structure in the genetic biobank era irrelevant, a challenge, or an opportunity?
DJ Lawson, NM Davies, S Haworth, B Ashraf, L Howe, A Crawford, ...
Human genetics 139 (1), 23-41, 2020
1042020
Novel genetic loci affecting facial shape variation in humans
Z Xiong, G Dankova, LJ Howe, MK Lee, PG Hysi, MA de Jong, G Zhu, ...
Elife 8, e49898, 2019
732019
Genetic evidence for assortative mating on alcohol consumption in the UK Biobank
LJ Howe, DJ Lawson, NM Davies, BS Pourcain, SJ Lewis, G Davey Smith, ...
Nature Communications 10 (1), 1-10, 2019
672019
Investigating the shared genetics of non-syndromic cleft lip/palate and facial morphology
LJ Howe, MK Lee, GC Sharp, G Davey Smith, B St Pourcain, JR Shaffer, ...
PLoS Genetics 14 (8), e1007501, 2018
592018
Modeling assortative mating and genetic similarities between partners, siblings, and in-laws
FA Torvik, EM Eilertsen, LJ Hannigan, R Cheesman, LJ Howe, P Magnus, ...
Nature Communications 13 (1), 1-10, 2022
512022
A GWAS in Latin Americans identifies novel face shape loci, implicating VPS13B and a Denisovan introgressed region in facial variation
B Bonfante, P Faux, N Navarro, J Mendoza-Revilla, M Dubied, C Montillot, ...
Science Advances 7 (6), eabc6160, 2021
492021
Body mass index, body dissatisfaction and adolescent smoking initiation
LJ Howe, L Trela-Larsen, M Taylor, J Heron, MR Munafò, AE Taylor
Drug & Alcohol Dependence 178, 143-149, 2017
462017
Association of Chromosome 9p21 with subsequent coronary heart disease events: a GENIUS-CHD study of individual participant data
RS Patel, AF Schmidt, V Tragante, RO McCubrey, MV Holmes, LJ Howe, ...
Circulation: Genomic and Precision Medicine 12 (4), e002471, 2019
332019
Evidence for DNA methylation mediating genetic liability to non-syndromic cleft lip/palate
LJ Howe, TG Richardson, R Arathimos, L Alvizi, MR Passos-Bueno, ...
Epigenomics 11 (2), 133-145, 2019
312019
Cleft lip/palate and educational attainment: cause, consequence or correlation? A Mendelian randomization study
C Dardani, LJ Howe, N Mukhopadhyay, E Stergiakouli, Y Wren, ...
International journal of epidemiology 49 (4), 1282-1293, 2020
292020
Polygenic risk scores for coronary artery disease and subsequent event risk amongst established cases
LJ Howe, F Dudbridge, AF Schmidt, C Finan, S Denaxas, FW Asselbergs, ...
Human molecular genetics 29 (8), 1388-1395, 2020
292020
Subsequent event risk in individuals with established coronary heart disease: design and rationale of the GENIUS-CHD consortium
RS Patel, V Tragante, AF Schmidt, RO McCubrey, MV Holmes, LJ Howe, ...
Circulation: Genomic and Precision Medicine 12 (4), e002470, 2019
282019
Interpreting Mendelian randomization estimates of the effects of categorical exposures such as disease status and educational attainment
LJ Howe, M Tudball, GD Smith, NM Davies
International journal of epidemiology, 0
27*
系统目前无法执行此操作,请稍后再试。
文章 1–20