关注
Stephen Connelly B.Sc., Ph.D.,
Stephen Connelly B.Sc., Ph.D.,
在 scripps.edu 的电子邮件经过验证
标题
引用次数
引用次数
年份
A structural analysis of M protein in coronavirus assembly and morphology
BW Neuman, G Kiss, AH Kunding, D Bhella, MF Baksh, S Connelly, ...
Journal of structural biology 174 (1), 11-22, 2011
10222011
Tafamidis, a potent and selective transthyretin kinetic stabilizer that inhibits the amyloid cascade
CE Bulawa, S Connelly, M DeVit, L Wang, C Weigel, JA Fleming, ...
Proceedings of the National Academy of Sciences, 2012
7402012
The transthyretin amyloidoses: from delineating the molecular mechanism of aggregation linked to pathology to a regulatory-agency-approved drug
SM Johnson, S Connelly, C Fearns, ET Powers, JW Kelly
Journal of Molecular Biology, 2012
3692012
Structure-based design of kinetic stabilizers that ameliorate the transthyretin amyloidoses
S Connelly, S Choi, SM Johnson, JW Kelly, IA Wilson
Current opinion in structural biology 20 (1), 54-62, 2010
1982010
AG10 inhibits amyloidogenesis and cellular toxicity of the familial amyloid cardiomyopathy-associated V122I transthyretin
SC Penchala, S Connelly, Y Wang, MS Park, L Zhao, A Baranczak, ...
Proceedings of the National Academy of Sciences 110 (24), 9992-9997, 2013
1712013
Aromatic sulfonyl fluorides covalently kinetically stabilize transthyretin to prevent amyloidogenesis while affording a fluorescent conjugate
NP Grimster, S Connelly, A Baranczak, J Dong, LB Krasnova, ...
Journal of the American Chemical Society 135 (15), 5656-5668, 2013
1652013
Biochemical and structural evaluation of highly selective 2-arylbenzoxazole-based transthyretin amyloidogenesis inhibitors
SM Johnson, S Connelly, IA Wilson, JW Kelly
Journal of medicinal chemistry 51 (2), 260-270, 2008
1612008
Chemoselective small molecules that covalently modify one lysine in a non-enzyme protein in plasma
S Choi, S Connelly, N Reixach, IA Wilson, JW Kelly
Nature chemical biology 6 (2), 133-139, 2010
1132010
A Fluorogenic Aryl Fluorosulfate for Intraorganellar Transthyretin Imaging in Living Cells and in Caenorhabditis elegans
A Baranczak, Y Liu, S Connelly, WGH Du, ER Greiner, JC Genereux, ...
Journal of the American Chemical Society 137 (23), 7404-7414, 2015
1042015
Potent kinetic stabilizers that prevent transthyretin-mediated cardiomyocyte proteotoxicity
MM Alhamadsheh, S Connelly, A Cho, N Reixach, ET Powers, DW Pan, ...
Science translational medicine 3 (97), 97ra81-97ra81, 2011
972011
Toward optimization of the linker substructure common to transthyretin amyloidogenesis inhibitors using biochemical and structural studies
SM Johnson, S Connelly, IA Wilson, JW Kelly
Journal of medicinal chemistry 51 (20), 6348-6358, 2008
962008
Akt phosphorylation and regulation of transketolase is a nodal point for amino acid control of purine synthesis
A Saha, S Connelly, J Jiang, S Zhuang, DT Amador, T Phan, RB Pilz, ...
Molecular cell 55 (2), 264-276, 2014
922014
Inhibition of Hsp90 with synthetic macrolactones: synthesis and structural and biological evaluation of ring and conformational analogs of radicicol
N Proisy, SY Sharp, K Boxall, S Connelly, SM Roe, C Prodromou, ...
Chemistry & biology 13 (11), 1203-1215, 2006
862006
A substructure combination strategy to create potent and selective transthyretin kinetic stabilizers that prevent amyloidogenesis and cytotoxicity
S Choi, N Reixach, S Connelly, SM Johnson, IA Wilson, JW Kelly
Journal of the American Chemical Society 132 (4), 1359-1370, 2010
752010
The phosphatidylinositol 3-kinase/akt cassette regulates purine nucleotide synthesis
W Wang, A Fridman, W Blackledge, S Connelly, IA Wilson, RB Pilz, ...
Journal of Biological Chemistry 284 (6), 3521-3528, 2009
742009
Natural methods of protein stabilization: thermostable biocatalysts
JA Littlechild, J Guy, S Connelly, L Mallett, S Waddell, CA Rye, K Line, ...
Biochemical Society Transactions 35 (6), 1558-1563, 2007
662007
Toward optimization of the second aryl substructure common to transthyretin amyloidogenesis inhibitors using biochemical and structural studies
SM Johnson, S Connelly, IA Wilson, JW Kelly
Journal of medicinal chemistry 52 (4), 1115-1125, 2009
582009
Stabilizing the CH2 Domain of an Antibody by Engineering in an Enhanced Aromatic Sequon
W Chen, L Kong, S Connelly, JM Dendle, Y Liu, IA Wilson, ET Powers, ...
ACS chemical biology 11 (7), 1852-1861, 2016
492016
The CD6/ALCAM pathway promotes lupus nephritis via T cell–mediated responses
SA Chalmers, RA Ramachandran, SJ Garcia, E Der, L Herlitz, J Ampudia, ...
The Journal of Clinical Investigation 132 (1), 2022
432022
Bifunctional coumarin derivatives that inhibit transthyretin amyloidogenesis and serve as fluorescent transthyretin folding sensors
N Myung, S Connelly, B Kim, SJ Park, IA Wilson, JW Kelly, S Choi
Chemical Communications 49 (80), 9188-9190, 2013
412013
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