Extremely high genetic diversity in a single tumor points to prevalence of non-Darwinian cell evolution S Ling#, Z Hu#, Z Yang#, F Yang#, Y Li, P Lin, K Chen, L Dong, L Cao, ... Proceedings of the National Academy of Sciences 112 (47), E6496-E6505, 2015 | 394 | 2015 |
Quantitative evidence for early metastatic seeding in colorectal cancer Z Hu, J Ding, Z Ma, R Sun, JA Seoane, J Scott Shaffer, CJ Suarez, ... Nature genetics 51 (7), 1113-1122, 2019 | 375 | 2019 |
Multi-cancer analysis of clonality and the timing of systemic spread in paired primary tumors and metastases Z Hu, Z Li, Z Ma, C Curtis Nature Genetics 52, 701–708, 2020 | 261 | 2020 |
Between-region genetic divergence reflects the mode and tempo of tumor evolution R Sun#, Z Hu#, A Sottoriva, TA Graham, A Harpak, Z Ma, JM Fischer, ... Nature Genetics 49 (7), 1015-1024, 2017 | 170 | 2017 |
A population genetics perspective on the determinants of intra-tumor heterogeneity Z Hu, R Sun, C Curtis Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1867 (2), 109–126, 2017 | 62 | 2017 |
Clonal replacement and heterogeneity in breast tumors treated with neoadjuvant HER2-targeted therapy JL Caswell-Jin, K McNamara, JG Reiter, R Sun, Z Hu, Z Ma, J Ding, ... Nature communications 10 (1), 657, 2019 | 56 | 2019 |
Intron 3 16 bp duplication polymorphism of TP53 contributes to cancer susceptibility Z Hu, X Li, X Qu, Y He, BZ Ring, L Su Carcinogenesis 31 (4), 643-647, 2010 | 55 | 2010 |
Looking backward in time to define the chronology of metastasis Z Hu, C Curtis Nature Communications 11 (1), 1-4, 2020 | 49 | 2020 |
Big Bang tumor growth and clonal evolution R Sun, Z Hu, C Curtis Cold Spring Harbor Perspectives in Medicine, doi: 10.1101/cshperspect.a028381, 2017 | 48 | 2017 |
Putative EPHX1 Enzyme Activity Is Related with Risk of Lung and Upper Aerodigestive Tract Cancers X Li#, Z Hu#, X Qu, J Zhu, L Li, BZ Ring, L Su PLoS ONE 6 ((3):e14749), 2011 | 46 | 2011 |
Is the evolution in tumors Darwinian or non-Darwinian? HY Wang, Y Chen, D Tong, S Ling, Z Hu, Y Tao, X Lu, CI Wu National Science Review, https://doi.org/10.1093/nsr/nwx076, 2018 | 30 | 2018 |
Genetic load and potential mutational meltdown in cancer cell populations Y Zhang, Y Li, T Li, X Shen, T Zhu, Y Tao, X Li, D Wang, Q Ma, Z Hu, J Liu, ... Molecular biology and evolution 36 (3), 541-552, 2019 | 24 | 2019 |
Age-dependent transition from cell-level to population-level control in murine intestinal homeostasis revealed by coalescence analysis Z Hu, YX Fu, AJ Greenberg, CI Wu, W Zhai PLoS Genetics 9 ((2):e1003326), 2013 | 17 | 2013 |
Patient‐Derived Upper Tract Urothelial Carcinoma Organoids as a Platform for Drug Screening Z Li, H Xu, Y Gong, W Chen, Y Zhan, L Yu, Y Sun, A Li, S He, B Guan, ... Advanced Science 9 (4), 2103999, 2022 | 13 | 2022 |
A genetic bottleneck of mitochondrial DNA during human lymphocyte development Z Tang#, Z Lu#, B Chen, W Zhang, H Chang*, Z Hu*, J Xu* Molecular Biology and Evolution, 2022 | 12 | 2022 |
Further genetic diversification in multiple tumors and an evolutionary perspective on therapeutics Y Tao#, Z Hu#, S Ling#, SH Yeh, W Zhai, K Chen, C Li, Y Wang, K Wang, ... bioRxiv, 2015 | 11 | 2015 |
PhyloVelo enhances transcriptomic velocity field mapping using monotonically expressed genes K Wang, L Hou, X Wang, X Zhai, Z Lu, Z Zi, W Zhai, X He, C Curtis, ... Nature Biotechnology 42 (5), 778-789, 2024 | 10 | 2024 |
Delineating the longitudinal tumor evolution using organoid models Z Lu, B Nie, W Zhai, Z Hu Journal of Genetics and Genomics 48 (7), 560-570, 2021 | 10 | 2021 |
Cell division history encodes directional information of fate transitions K Wang, L Hou, Z Lu, X Wang, Z Zi, W Zhai, X He, C Curtis, D Zhou, Z Hu bioRxiv, 2022.10. 06.511094, 2022 | 5 | 2022 |
Genome instability is associated with ethnic differences between Asians and Europeans in hepatocellular carcinoma NA Kaya, J Chen, H Lai, H Yang, L Ma, X Liu, JS Alvarez, J Liu, ... Theranostics 12 (10), 4703, 2022 | 5 | 2022 |