Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila C Burnett, S Valentini, F Cabreiro, M Goss, M Somogyvári, MD Piper, ... nature 477 (7365), 482-485, 2011 | 762 | 2011 |
Delaying aging and the aging-associated decline in protein homeostasis by inhibition of tryptophan degradation AT Van Der Goot, W Zhu, RP Vázquez-Manrique, RI Seinstra, K Dettmer, ... Proceedings of the National Academy of Sciences 109 (37), 14912-14917, 2012 | 228 | 2012 |
Frataxin interacts functionally with mitochondrial electron transport chain proteins P Gonzalez-Cabo, RP Vázquez-Manrique, MA García-Gimeno, P Sanz, ... Human molecular genetics 14 (15), 2091-2098, 2005 | 181 | 2005 |
Reduction of Caenorhabditis elegans frataxin increases sensitivity to oxidative stress, reduces lifespan, and causes lethality in a mitochondrial complex II mutant RP Vázquez‐Manrique, P González‐Cabo, S Ros, H Aziz, HA Baylis, ... The FASEB Journal 20 (1), 172-174, 2006 | 116 | 2006 |
AMPK activation protects from neuronal dysfunction and vulnerability across nematode, cellular and mouse models of Huntington's disease RP Vázquez-Manrique, F Farina, K Cambon, M Dolores Sequedo, ... Human molecular genetics 25 (6), 1043-1058, 2016 | 103 | 2016 |
Targeted next generation sequencing for molecular diagnosis of Usher syndrome MJ Aparisi, E Aller, C Fuster-García, G García-García, R Rodrigo, ... Orphanet journal of rare diseases 9, 1-15, 2014 | 103 | 2014 |
Genotype and phenotype analysis of Friedreich's ataxia compound heterozygous patients M De Castro, J García-Planells, E Monrós, J Cañizares, ... Human genetics 106, 86-92, 2000 | 83 | 2000 |
Metformin intake associates with better cognitive function in patients with Huntington's disease D Hervás, V Fornés-Ferrer, AP Gómez-Escribano, MD Sequedo, C Peiró, ... PloS one 12 (6), e0179283, 2017 | 79 | 2017 |
USH2A gene editing using the CRISPR system C Fuster-García, G García-García, E González-Romero, T Jaijo, ... Molecular Therapy-Nucleic Acids 8, 529-541, 2017 | 72 | 2017 |
Large-scale functional RNAi screen in C. elegans identifies genes that regulate the dysfunction of mutant polyglutamine neurons FX Lejeune, L Mesrob, F Parmentier, C Bicep, RP Vazquez-Manrique, ... BMC genomics 13, 1-14, 2012 | 64 | 2012 |
Integration of β-catenin, sirtuin, and FOXO signaling protects from mutant huntingtin toxicity JA Parker, RP Vazquez-Manrique, C Tourette, F Farina, N Offner, ... Journal of Neuroscience 32 (36), 12630-12640, 2012 | 61 | 2012 |
Metformin treatment reduces motor and neuropsychiatric phenotypes in the zQ175 mouse model of Huntington disease A Sanchis, MA García-Gimeno, AJ Cañada-Martínez, MD Sequedo, ... Experimental & Molecular Medicine 51 (6), 1-16, 2019 | 56 | 2019 |
The Wnt receptor Ryk reduces neuronal and cell survival capacity by repressing FOXO activity during the early phases of mutant huntingtin pathogenicity C Tourette, F Farina, RP Vazquez-Manrique, AM Orfila, J Voisin, ... PLoS biology 12 (6), e1001895, 2014 | 51 | 2014 |
TRPM channels are required for rhythmicity in the ultradian defecation rhythm of C. elegans CSM Kwan, RP Vázquez-Manrique, S Ly, K Goyal, HA Baylis BMC physiology 8, 1-11, 2008 | 47 | 2008 |
Inositol 1,4,5-Trisphosphate Signalling Regulates the Avoidance Response to Nose Touch in Caenorhabditis elegans DS Walker, RP Vazquez-Manrique, NJD Gower, E Gregory, WR Schafer, ... PLoS Genetics 5 (9), e1000636, 2009 | 46 | 2009 |
CRISPR to fix bad blood: a new tool in basic and clinical hematology E González-Romero, C Martínez-Valiente, C García-Ruiz, ... haematologica 104 (5), 881, 2019 | 44 | 2019 |
Phospholipase C-ε Regulates Epidermal Morphogenesis in Caenorhabditis elegans RP Vázquez-Manrique, AI Nagy, JC Legg, OAM Bales, S Ly, HA Baylis PLoS genetics 4 (3), e1000043, 2008 | 43 | 2008 |
Loss of glutathione redox homeostasis impairs proteostasis by inhibiting autophagy-dependent protein degradation D Guerrero-Gómez, JA Mora-Lorca, B Sáenz-Narciso, ... Cell Death & Differentiation 26 (9), 1545-1565, 2019 | 37 | 2019 |
Disruption of the ATP-binding cassette B7 (ABTM-1/ABCB7) induces oxidative stress and premature cell death in Caenorhabditis elegans P González-Cabo, A Bolinches-Amorós, J Cabello, S Ros, S Moreno, ... Journal of Biological Chemistry 286 (24), 21304-21314, 2011 | 34 | 2011 |
Reactive species in Huntington disease: are they really the radicals you want to catch? J Bono-Yagüe, AP Gómez-Escribano, JM Millán, RP Vázquez-Manrique Antioxidants 9 (7), 577, 2020 | 31 | 2020 |