Pyroglutamation of amyloid-βx-42 (Aβx-42) followed by Aβ1–40 deposition underlies plaque polymorphism in progressing Alzheimer’s disease pathology W Michno, S Nyström, P Wehrli, T Lashley, G Brinkmalm, L Guerard, ... Journal of Biological Chemistry 294 (17), 6719-6732, 2019 | 73 | 2019 |
Molecular imaging mass spectrometry for probing protein dynamics in neurodegenerative disease pathology W Michno, PM Wehrli, K Blennow, H Zetterberg, J Hanrieder Journal of neurochemistry 151 (4), 488-506, 2019 | 57 | 2019 |
GM1 locates to mature amyloid structures implicating a prominent role for glycolipid-protein interactions in Alzheimer pathology W Michno, PM Wehrli, H Zetterberg, K Blennow, J Hanrieder Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics 1867 (5), 458-467, 2019 | 44 | 2019 |
Maximising the potential for bacterial phenotyping using time‐of‐flight secondary ion mass spectrometry with multivariate analysis and tandem mass spectrometry PM Wehrli, E Lindberg, TB Angerer, AE Wold, J Gottfries, JS Fletcher Surface and interface analysis 46 (S1), 173-176, 2014 | 28 | 2014 |
Chemical imaging of evolving amyloid plaque pathology and associated Aβ peptide aggregation in a transgenic mouse model of Alzheimer’s disease W Michno, P Wehrli, SR Meier, D Sehlin, S Syvänen, H Zetterberg, ... Journal of Neurochemistry 152 (5), 602-616, 2020 | 24 | 2020 |
Structural amyloid plaque polymorphism is associated with distinct lipid accumulations revealed by trapped ion mobility mass spectrometry imaging W Michno, PM Wehrli, S Koutarapu, C Marsching, K Minta, J Ge, ... Journal of Neurochemistry 160 (4), 482-498, 2022 | 23 | 2022 |
Exploring bacterial phenotypic diversity using factorial design and FTIR multivariate fingerprinting PM Wehrli, E Lindberg, O Svensson, A Sparén, M Josefson, RH Dunstan, ... Journal of Chemometrics 28 (8), S681-S686, 2014 | 21 | 2014 |
Discovery and development of substituted thiadiazoles as inhibitors of Staphylococcus aureus Sortase A PM Wehrli, I Uzelac, T Olsson, T Jacso, D Tietze, J Gottfries Bioorganic & Medicinal Chemistry 27 (19), 115043, 2019 | 19 | 2019 |
Chemometric strategies for sensitive annotation and validation of anatomical regions of interest in complex imaging mass spectrometry data PM Wehrli, W Michno, K Blennow, H Zetterberg, J Hanrieder Journal of The American Society for Mass Spectrometry 30 (11), 2278-2288, 2019 | 15 | 2019 |
Investigating the Role of the Stringent Response in Lipid Modifications during the Stationary Phase in E. coli by Direct Analysis with Time-of-Flight-Secondary Ion … PM Wehrli, TB Angerer, A Farewell, JS Fletcher, J Gottfries Analytical Chemistry 88 (17), 8680-8688, 2016 | 15 | 2016 |
Correlative chemical imaging and spatial chemometrics delineate Alzheimer plaque heterogeneity at high spatial resolution PM Wehrli, J Ge, W Michno, S Koutarapu, A Dreos, D Jha, H Zetterberg, ... JACS au 3 (3), 762-774, 2023 | 9 | 2023 |
Spatial Chemometrics and Comprehensive Chemical Imaging Based Molecular Histopathology Delineates Anatomical Heterogeneity at Single Pixel Resolution P Wehrli, W Michno, L Guerard, J Fernandez-Rodriguez, A Bergh, ... | 2 | 2020 |
Correlative Chemical Imaging and Spatial Chemometrics Delineate Alzheimer Plaque Heterogeneity at High Resolution P Wehrli, J Ge, W Michno, S Koutarapu, A Dreos, D Jha, H Zetterberg, ... | | 2022 |
Amyloid Plaque Polymorphism is Associated with Distinct Lipid Accumulations Revealed by Trapped Ion Mobility Mass Spectrometry Imaging (TIMS MSI) W Michno, P Wehrli, S Koutarapu, C Marsching, K Minta, J Ge, S Meyer, ... | | 2021 |
Towards Anti-Virulence Antimicrobials, Discovery and Development of Sortase A Inhibitors and Investigations of Bacterial Phenotypes P Wehrli | | 2016 |
Towards Anti-Virulence Antimicrobials PM Wehrli University of Gothenburg, 2016 | | 2016 |