RecBCD enzyme is a bipolar DNA helicase MS Dillingham, M Spies, SC Kowalczykowski Nature 423 (6942), 893-897, 2003 | 278 | 2003 |
A molecular throttle: the recombination hotspot χ controls DNA translocation by the RecBCD helicase M Spies, PR Bianco, MS Dillingham, N Handa, RJ Baskin, ... Cell 114 (5), 647-654, 2003 | 206 | 2003 |
Mismatch repair during homologous and homeologous recombination M Spies, R Fishel Cold Spring Harbor perspectives in biology 7 (3), a022657, 2015 | 183 | 2015 |
Human Rad52 binds and wraps single-stranded DNA and mediates annealing via two hRad52–ssDNA complexes JM Grimme, M Honda, R Wright, Y Okuno, E Rothenberg, AV Mazin, T Ha, ... Nucleic acids research 38 (9), 2917-2930, 2010 | 174 | 2010 |
RecBCD enzyme switches lead motor subunits in response to χ recognition M Spies, I Amitani, RJ Baskin, SC Kowalczykowski Cell 131 (4), 694-705, 2007 | 148 | 2007 |
Small-molecule inhibitors targeting DNA repair and DNA repair deficiency in research and cancer therapy SR Hengel, MA Spies, M Spies Cell chemical biology 24 (9), 1101-1119, 2017 | 145 | 2017 |
A structural and dynamic model for the assembly of Replication Protein A on single-stranded DNA LA Yates, RJ Aramayo, N Pokhrel, CC Caldwell, JA Kaplan, RL Perera, ... Nature communications 9 (1), 5447, 2018 | 132 | 2018 |
Human Rad52-mediated homology search and annealing occurs by continuous interactions between overlapping nucleoprotein complexes E Rothenberg, JM Grimme, M Spies, T Ha Proceedings of the National Academy of Sciences 105 (51), 20274-20279, 2008 | 131 | 2008 |
The iron-containing domain is essential in Rad3 helicases for coupling of ATP hydrolysis to DNA translocation and for targeting the helicase to the single-stranded DNA-double … RA Pugh, M Honda, H Leesley, A Thomas, Y Lin, MJ Nilges, IKO Cann, ... Journal of Biological Chemistry 283 (3), 1732-1743, 2008 | 122 | 2008 |
The RecA binding locus of RecBCD is a general domain for recruitment of DNA strand exchange proteins M Spies, SC Kowalczykowski Molecular cell 21 (4), 573-580, 2006 | 120 | 2006 |
Dynamics and selective remodeling of the DNA-binding domains of RPA N Pokhrel, CC Caldwell, EI Corless, EA Tillison, J Tibbs, N Jocic, ... Nature structural & molecular biology 26 (2), 129-136, 2019 | 102 | 2019 |
G-quadruplex recognition and remodeling by the FANCJ helicase CG Wu, M Spies Nucleic acids research 44 (18), 8742-8753, 2016 | 102 | 2016 |
Homologous recombination by the RecBCD and RecF pathways M Spies, SC Kowalczykowski The bacterial chromosome, 389-403, 2004 | 102 | 2004 |
Dynamic binding of replication protein a is required for DNA repair R Chen, S Subramanyam, AH Elcock, M Spies, MS Wold Nucleic acids research 44 (12), 5758-5772, 2016 | 99 | 2016 |
Rad52 prevents excessive replication fork reversal and protects from nascent strand degradation E Malacaria, GM Pugliese, M Honda, V Marabitti, FA Aiello, M Spies, ... Nature communications 10 (1), 1412, 2019 | 96 | 2019 |
Single-molecule analysis reveals differential effect of ssDNA-binding proteins on DNA translocation by XPD helicase M Honda, J Park, RA Pugh, T Ha, M Spies Molecular cell 35 (5), 694-703, 2009 | 95 | 2009 |
Sequence-dependent base pair stepping dynamics in XPD helicase unwinding Z Qi, RA Pugh, M Spies, YR Chemla eLife 2, 2013 | 91 | 2013 |
Survival of the replication checkpoint deficient cells requires MUS81-RAD52 function I Murfuni, G Basile, S Subramanyam, E Malacaria, M Bignami, M Spies, ... PLoS genetics 9 (10), e1003910, 2013 | 86 | 2013 |
Dynamic elements of replication protein A at the crossroads of DNA replication, recombination, and repair CC Caldwell, M Spies Critical reviews in biochemistry and molecular biology 55 (5), 482-507, 2020 | 82 | 2020 |
Small-molecule inhibitors identify the RAD52-ssDNA interaction as critical for recovery from replication stress and for survival of BRCA2 deficient cells SR Hengel, E Malacaria, L Folly da Silva Constantino, FE Bain, A Diaz, ... Elife 5, e14740, 2016 | 81 | 2016 |