关注
Chang Gong
Chang Gong
AstraZeneca
在 jhu.edu 的电子邮件经过验证
标题
引用次数
引用次数
年份
Multiscale Agent-Based and Hybrid Modeling of the Tumor Immune Microenvironment
KA Norton, C Gong, S Jamalian, AS Popel
Processes 7 (1), 37, 2019
1472019
A computational multiscale agent-based model for simulating spatio-temporal tumour immune response to PD1 and PDL1 inhibition
C Gong, O Milberg, B Wang, P Vicini, R Narwal, L Roskos, AS Popel
Journal of The Royal Society Interface 14 (134), 20170320, 2017
1452017
A QSP Model for Predicting Clinical Responses to Monotherapy, Combination and Sequential Therapy Following CTLA-4, PD-1, and PD-L1 Checkpoint Blockade
O Milberg, C Gong, M Jafarnejad, IH Bartelink, B Wang, P Vicini, R Narwal, ...
Scientific Reports 9 (1), 1-17, 2019
802019
A Computational Model of Neoadjuvant PD-1 Inhibition in Non-Small Cell Lung Cancer
M Jafarnejad, C Gong, E Gabrielson, IH Bartelink, P Vicini, B Wang, ...
The AAPS Journal 21 (5), 79, 2019
592019
Predicting lymph node output efficiency using systems biology
C Gong, JT Mattila, M Miller, JAL Flynn, JJ Linderman, D Kirschner
Journal of theoretical biology 335, 169-184, 2013
592013
Digital pathology analysis quantifies spatial heterogeneity of CD3, CD4, CD8, CD20, and FoxP3 immune markers in triple-negative breast cancer
H Mi, C Gong, J Sulam, EJ Fertig, AS Szalay, EM Jaffee, V Stearns, ...
Frontiers in Physiology 11, 1325, 2020
522020
Harnessing the heterogeneity of T cell differentiation fate to fine-tune generation of effector and memory T cells
C Gong, JJ Linderman, D Kirschner
Frontiers in immunology 5, 2014
482014
Quantitative Characterization of CD8+ T Cell Clustering and Spatial Heterogeneity in Solid Tumors
C Gong, RA Anders, Q Zhu, JM Taube, B Green, W Cheng, IH Bartelink, ...
Frontiers in oncology 8, 2018
412018
Computational and empirical studies predict Mycobacterium tuberculosis-specific T cells as a biomarker for infection outcome
S Marino, HP Gideon, C Gong, S Mankad, JT McCrone, PL Lin, ...
PLoS computational biology 12 (4), e1004804, 2016
412016
A multi-scale approach to designing therapeutics for tuberculosis
JJ Linderman, NA Cilfone, E Pienaar, C Gong, DE Kirschner
Integrative Biology 7 (5), 591-609, 2015
382015
Simulations of tumor growth and response to immunotherapy by coupling a spatial agent-based model with a whole-patient quantitative systems pharmacology model
A Ruiz-Martinez, C Gong, H Wang, RJ Sové, H Mi, H Kimko, AS Popel
PLoS computational biology 18 (7), e1010254, 2022
282022
A Spatial Quantitative Systems Pharmacology Platform spQSP-IO for Simulations of Tumor—Immune Interactions and Effects of Checkpoint Inhibitor Immunotherapy
C Gong, A Ruiz-Martinez, H Kimko, AS Popel
Cancers 13 (15), 3751, 2021
252021
Integrating single cell sequencing with a spatial quantitative systems pharmacology model spQSP for personalized prediction of triple-negative breast cancer immunotherapy response
S Zhang, C Gong, A Ruiz-Martinez, H Wang, E Davis-Marcisak, ...
ImmunoInformatics, 100002, 2021
242021
A population model capturing dynamics of tuberculosis granulomas predicts host infection outcomes
C Gong, JJ Linderman, D Kirschner
Mathematical biosciences and engineering: MBE 12 (3), 625, 2015
202015
Strategic Priming with Multiple Antigens Can Yield Memory Cell Phenotypes Optimized for Infection with Mycobacterium tuberculosis: a Computational Study
C Ziraldo, C Gong, D Kirschner, JJ Linderman
Frontiers in Microbiology 6, 1477, 2015
152015
Quantifying Intratumoral Heterogeneity and Immunoarchitecture Generated In-Silico by a Spatial Quantitative Systems Pharmacology Model
M Nikfar, H Mi, C Gong, H Kimko, AS Popel
Cancers 15 (10), 2750, 2023
52023
Systems pharmacology to predict cellular biomarkers and optimize mono-and combination-therapy regimens: Focusing on immune checkpoint targets PD-1, PD-L1 and CTLA-4
O Milberg, C Gong, B Wang, P Vicini, R Narwal, L Roskos, A Popel
Cancer Research 77 (13 Supplement), 4531-4531, 2017
22017
A multiscale computational model for spatio-temporal tumor immune response
C Gong, O Milberg, B Wang, P Vicini, R Narwal, L Roskos, AS Popel
Cancer Research 77 (13 Supplement), 975-975, 2017
12017
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