标题/作者	年份
A single-cell atlas of the peripheral immune response in patients with severe COVID-19 AJ Wilk, A Rustagi, NQ Zhao, J Roque, GJ Martínez-Colón, JL McKechnie, ... Nature medicine 26 (7), 1070-1076	2020
Clonal replacement of tumor-specific T cells following PD-1 blockade KE Yost, AT Satpathy, DK Wells, Y Qi, C Wang, R Kageyama, ... Nature medicine 25 (8), 1251-1259	2019
Defining ‘T cell exhaustion’ CU Blank, WN Haining, W Held, PG Hogan, A Kallies, E Lugli, RC Lynn, ... Nature Reviews Immunology 19 (11), 665-674	2019
CD8+ T cell states in human cancer: insights from single-cell analysis AM Van der Leun, DS Thommen, TN Schumacher Nature Reviews Cancer 20 (4), 218-232	2020
TIM3 comes of age as an inhibitory receptor Y Wolf, AC Anderson, VK Kuchroo Nature Reviews Immunology 20 (3), 173-185	2020
An intra-tumoral niche maintains and differentiates stem-like CD8 T cells CS Jansen, N Prokhnevska, VA Master, MG Sanda, JW Carlisle, MA Bilen, ... Nature 576 (7787), 465-470	2019
Developmental relationships of four exhausted CD8+ T cell subsets reveals underlying transcriptional and epigenetic landscape control mechanisms JC Beltra, S Manne, MS Abdel-Hakeem, M Kurachi, JR Giles, Z Chen, ... Immunity 52 (5), 825-841. e8	2020
Advances in the development of personalized neoantigen-based therapeutic cancer vaccines E Blass, PA Ott Nature Reviews Clinical Oncology 18 (4), 215-229	2021
Peripheral T cell expansion predicts tumour infiltration and clinical response TD Wu, S Madireddi, PE de Almeida, R Banchereau, YJJ Chen, AS Chitre, ... Nature 579 (7798), 274-278	2020
Acquired resistance to immune checkpoint inhibitors AJ Schoenfeld, MD Hellmann Cancer cell 37 (4), 443-455	2020
Single-cell RNA-seq reveals TOX as a key regulator of CD8+ T cell persistence in chronic infection C Yao, HW Sun, NE Lacey, Y Ji, EA Moseman, HY Shih, EF Heuston, ... Nature immunology 20 (7), 890-901	2019
Tumor-infiltrating lymphocytes in the immunotherapy era ST Paijens, A Vledder, M de Bruyn, HW Nijman Cellular & molecular immunology 18 (4), 842-859	2021
Obesity shapes metabolism in the tumor microenvironment to suppress anti-tumor immunity AE Ringel, JM Drijvers, GJ Baker, A Catozzi, JC García-Cañaveras, ... Cell 183 (7), 1848-1866. e26	2020
Intratumoral heterogeneity in cancer progression and response to immunotherapy I Vitale, E Shema, S Loi, L Galluzzi Nature medicine 27 (2), 212-224	2021
Opposing functions of interferon coordinate adaptive and innate immune responses to cancer immune checkpoint blockade JL Benci, LR Johnson, R Choa, Y Xu, J Qiu, Z Zhou, B Xu, D Ye, ... Cell 178 (4), 933-948. e14	2019
Mitochondrial stress induced by continuous stimulation under hypoxia rapidly drives T cell exhaustion NE Scharping, DB Rivadeneira, AV Menk, PDA Vignali, BR Ford, ... Nature immunology 22 (2), 205-215	2021
Characteristics of anti-CD19 CAR T cell infusion products associated with efficacy and toxicity in patients with large B cell lymphomas Q Deng, G Han, N Puebla-Osorio, MCJ Ma, P Strati, B Chasen, E Dai, ... Nature medicine 26 (12), 1878-1887	2020
Transient rest restores functionality in exhausted CAR-T cells through epigenetic remodeling EW Weber, KR Parker, E Sotillo, RC Lynn, H Anbunathan, J Lattin, ... Science 372 (6537), eaba1786	2021
PD-L1 on dendritic cells attenuates T cell activation and regulates response to immune checkpoint blockade Q Peng, X Qiu, Z Zhang, S Zhang, Y Zhang, Y Liang, J Guo, H Peng, ... Nature communications 11 (1), 4835	2020
Pan-cancer single-cell landscape of tumor-infiltrating T cells L Zheng, S Qin, W Si, A Wang, B Xing, R Gao, X Ren, L Wang, X Wu, ... Science 374 (6574), abe6474	2021

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