Initial sequencing and analysis of the human genome US DOE Joint Genome Institute: Hawkins Trevor 4 Branscomb Elbert 4 Predki ... nature 409 (6822), 860-921, 2001 | 29307 | 2001 |
The COG database: an updated version includes eukaryotes RL Tatusov, ND Fedorova, JD Jackson, AR Jacobs, B Kiryutin, EV Koonin, ... BMC bioinformatics 4 (1), 1-14, 2003 | 4664 | 2003 |
A genomic perspective on protein families RL Tatusov, EV Koonin, DJ Lipman Science 278 (5338), 631-637, 1997 | 4181 | 1997 |
The COG database: a tool for genome-scale analysis of protein functions and evolution RL Tatusov, MY Galperin, DA Natale, EV Koonin Nucleic acids research 28 (1), 33-36, 2000 | 4040 | 2000 |
Cpf1 is a single RNA-guided endonuclease of a class 2 CRISPR-Cas system B Zetsche, JS Gootenberg, OO Abudayyeh, IM Slaymaker, KS Makarova, ... Cell 163 (3), 759-771, 2015 | 3839 | 2015 |
Small CRISPR RNAs guide antiviral defense in prokaryotes SJJ Brouns, MM Jore, M Lundgren, ER Westra, RJH Slijkhuis, ... Science 321 (5891), 960-964, 2008 | 3019 | 2008 |
Evolution and classification of the CRISPR–Cas systems KS Makarova, DH Haft, R Barrangou, SJJ Brouns, E Charpentier, ... Nature Reviews Microbiology 9 (6), 467-477, 2011 | 2945 | 2011 |
In vivo genome editing using Staphylococcus aureus Cas9 FA Ran, L Cong, WX Yan, DA Scott, JS Gootenberg, AJ Kriz, B Zetsche, ... Nature 520 (7546), 186-191, 2015 | 2621 | 2015 |
An updated evolutionary classification of CRISPR–Cas systems KS Makarova, YI Wolf, OS Alkhnbashi, F Costa, SA Shah, SJ Saunders, ... Nature Reviews Microbiology 13 (11), 722-736, 2015 | 2379 | 2015 |
The COG database: new developments in phylogenetic classification of proteins from complete genomes RL Tatusov, DA Natale, IV Garkavtsev, TA Tatusova, UT Shankavaram, ... Nucleic acids research 29 (1), 22-28, 2001 | 2202 | 2001 |
AAA+: A class of chaperone-like ATPases associated with the assembly, operation, and disassembly of protein complexes AF Neuwald, L Aravind, JL Spouge, EV Koonin Genome research 9 (1), 27-43, 1999 | 2187 | 1999 |
Nucleic acid detection with CRISPR-Cas13a/C2c2 JS Gootenberg, OO Abudayyeh, JW Lee, P Essletzbichler, AJ Dy, J Joung, ... Science 356 (6336), 438-442, 2017 | 2065 | 2017 |
De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-κB signalling IE Wertz, KM O'rourke, H Zhou, M Eby, L Aravind, S Seshagiri, P Wu, ... Nature 430 (7000), 694-699, 2004 | 2043 | 2004 |
Molecular cloning and disease association of hepatitis G virus: a transfusion-transmissible agent J Linnen, J Wages Jr, ZY Zhang-Keck, KE Fry, KZ Krawczynski, H Alter, ... Science 271 (5248), 505-508, 1996 | 2019 | 1996 |
Genome sequence of an obligate intracellular pathogen of humans: Chlamydia trachomatis RS Stephens, S Kalman, C Lammel, J Fan, R Marathe, L Aravind, ... Science 282 (5389), 754-759, 1998 | 1940 | 1998 |
Bacterial rhodopsin: evidence for a new type of phototrophy in the sea O Béja, L Aravind, EV Koonin, MT Suzuki, A Hadd, LP Nguyen, ... Science 289 (5486), 1902-1906, 2000 | 1710 | 2000 |
C2c2 is a single-component programmable RNA-guided RNA-targeting CRISPR effector OO Abudayyeh, JS Gootenberg, S Konermann, J Joung, IM Slaymaker, ... Science 353 (6299), aaf5573, 2016 | 1675 | 2016 |
A putative RNA-interference-based immune system in prokaryotes: computational analysis of the predicted enzymatic machinery, functional analogies with eukaryotic RNAi, and … KS Makarova, NV Grishin, SA Shabalina, YI Wolf, EV Koonin Biology direct 1 (1), 1-26, 2006 | 1630 | 2006 |
Comparative genomics of the lactic acid bacteria K Makarova, A Slesarev, Y Wolf, A Sorokin, B Mirkin, E Koonin, A Pavlov, ... Proceedings of the National Academy of Sciences 103 (42), 15611-15616, 2006 | 1611 | 2006 |
Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements AA Schäffer, L Aravind, TL Madden, S Shavirin, JL Spouge, YI Wolf, ... Nucleic acids research 29 (14), 2994-3005, 2001 | 1575 | 2001 |