| Plasticity in binding confers selectivity in ligand-induced protein degradation RP Nowak, SL DeAngelo, D Buckley, Z He, KA Donovan, J An, N Safaee, ... Nature chemical biology 14 (7), 706-714, 2018 | 368 | 2018 |
| Thalidomide promotes degradation of SALL4, a transcription factor implicated in Duane Radial Ray Syndrome KA Donovan, J An, RP Nowak, JC Yuan, EC Fink, BC Berry, BL Ebert, ... eLife 7, e38430, 2018 | 295 | 2018 |
| Homolog-Selective Degradation as a Strategy to Probe the Function of CDK6 in AML M Brand, B Jiang, S Bauer, KA Donovan, Y Liang, ES Wang, RP Nowak, ... Cell chemical biology 26 (2), 300-306. e9, 2019 | 185 | 2019 |
| The CDK inhibitor CR8 acts as a molecular glue degrader that depletes cyclin K M Słabicki, Z Kozicka, G Petzold, YD Li, M Manojkumar, RD Bunker, ... Nature 585 (7824), 293-297, 2020 | 181 | 2020 |
| Development of dual and selective degraders of cyclin‐dependent kinases 4 and 6 B Jiang, ES Wang, KA Donovan, Y Liang, ES Fischer, T Zhang, NS Gray Angewandte Chemie International Edition 58 (19), 6321-6326, 2019 | 181 | 2019 |
| Targeted degradation of aberrant tau in frontotemporal dementia patient-derived neuronal cell models MC Silva, FM Ferguson, Q Cai, KA Donovan, G Nandi, D Patnaik, T Zhang, ... eLife 8, e45457, 2019 | 180 | 2019 |
| Exploring Targeted Degradation Strategy for Oncogenic KRASG12C M Zeng, Y Xiong, N Safaee, RP Nowak, KA Donovan, CJ Yuan, B Nabet, ... Cell Chemical Biology 27 (1), 19-31. e6, 2020 | 171 | 2020 |
| Chemically Induced Degradation of Anaplastic Lymphoma Kinase (ALK) CE Powell, Y Gao, L Tan, KA Donovan, RP Nowak, A Loehr, M Bahcall, ... Journal of medicinal chemistry 61 (9), 4249-4255, 2018 | 154 | 2018 |
| Mapping the Degradable Kinome Provides a Resource for Expedited Degrader Development KA Donovan, FM Ferguson, JW Bushman, NA Eleuteri, D Bhunia, SS Ryu, ... Cell 183 (6), 1714-1731. e10, 2020 | 134 | 2020 |
| pSILAC mass spectrometry reveals ZFP91 as IMiD-dependent substrate of the CRL4CRBN ubiquitin ligase J An, CM Ponthier, R Sack, J Seebacher, MB Stadler, KA Donovan, ... Nature communications 8 (1), 15398, 2017 | 133 | 2017 |
| Structural complementarity facilitates E7820-mediated degradation of RBM39 by DCAF15 TB Faust, H Yoon, RP Nowak, KA Donovan, Z Li, Q Cai, NA Eleuteri, ... Nature chemical biology 16 (1), 7-14, 2020 | 124 | 2020 |
| Bruton tyrosine kinase degradation as a therapeutic strategy for cancer D Dobrovolsky, ES Wang, S Morrow, C Leahy, T Faust, RP Nowak, ... Blood, The Journal of the American Society of Hematology 133 (9), 952-961, 2019 | 123 | 2019 |
| Small-molecule-induced polymerization triggers degradation of BCL6 M Słabicki, H Yoon, J Koeppel, L Nitsch, SS Roy Burman, C Di Genua, ... Nature 588 (7836), 164-168, 2020 | 118 | 2020 |
| Small molecule degraders of the hepatitis C virus protease reduce susceptibility to resistance mutations M de Wispelaere, G Du, KA Donovan, T Zhang, NA Eleuteri, JC Yuan, ... Nature communications 10 (1), 3468, 2019 | 117 | 2019 |
| Discovery of an AKT Degrader with Prolonged Inhibition of Downstream Signaling I You, EC Erickson, KA Donovan, NA Eleuteri, ES Fischer, NS Gray, ... Cell Chemical Biology 27 (1), 66-73. e7, 2020 | 79 | 2020 |
| ER Stress Signaling Promotes the Survival of Cancer “Persister Cells” Tolerant to EGFR Tyrosine Kinase InhibitorsUfmylation-Regulated ER Stress and EGFR TKI Cell Persistence H Terai, S Kitajima, DS Potter, Y Matsui, LG Quiceno, T Chen, T Kim, ... Cancer research 78 (4), 1044-1057, 2018 | 77 | 2018 |
| Development and Characterization of a Wee1 Kinase Degrader Z Li, BJ Pinch, CM Olson, KA Donovan, RP Nowak, CE Mills, DA Scott, ... Cell Chemical Biology 27 (1), 57-65. e9, 2020 | 62 | 2020 |
| INK4 tumor suppressor proteins mediate resistance to CDK4/6 kinase inhibitors Q Li, B Jiang, J Guo, H Shao, IS Del Priore, Q Chang, R Kudo, Z Li, ... Cancer Discovery 12 (2), 356-371, 2022 | 49 | 2022 |
| Development of CDK2 and CDK5 Dual Degrader TMX‐2172 M Teng, J Jiang, Z He, NP Kwiatkowski, KA Donovan, CE Mills, C Victor, ... Angewandte Chemie 132 (33), 13969-13974, 2020 | 44 | 2020 |
| Selective Degradation of GSPT1 by Cereblon Modulators Identified via a Focused Combinatorial Library CE Powell, G Du, J Che, Z He, KA Donovan, H Yue, ES Wang, RP Nowak, ... ACS Chemical Biology 15 (10), 2722-2730, 2020 | 40 | 2020 |
Eric S FischerProfessor of Biological Chemistry and Molecular Pharmacology, Harvard Medical School在 crystal.harvard.edu 的电子邮件经过验证
