| Primary hepatocytes: current understanding of the regulation of metabolic enzymes and transporter proteins, and pharmaceutical practice for the use of hepatocytes in metabolism … NJ Hewitt, MJ Gómez Lechón, JB Houston, D Hallifax, HS Brown, ... Drug metabolism reviews 39 (1), 159-234, 2007 | 824 | 2007 |
| A simplified method for production and growth of multicellular tumor spheroids JM Yuhas, AP Li, AO Martinez, AJ Ladman Cancer research 37 (10), 3639-3643, 1977 | 667 | 1977 |
| Screening for human ADME/Tox drug properties in drug discovery AP Li Drug discovery today 6 (7), 357-366, 2001 | 638 | 2001 |
| Substrates of human hepatic cytochrome P450 3A4 AP Li, DL Kaminski, A Rasmussen Toxicology 104 (1-3), 1-8, 1995 | 426 | 1995 |
| Inhibition of transporter-mediated hepatic uptake as a mechanism for drug-drug interaction between cerivastatin and cyclosporin A Y Shitara, T Itoh, H Sato, AP Li, Y Sugiyama Journal of Pharmacology and Experimental Therapeutics 304 (2), 610-616, 2003 | 409 | 2003 |
| Cryopreserved human hepatocytes: characterization of drug-metabolizing activities and applications in higher throughput screening assays for hepatotoxicity, metabolic stability … AP Li, C Lu, JA Brent, C Pham, A Fackett, CE Ruegg, PM Silber Chemico-biological interactions 121 (1), 17-35, 1999 | 367 | 1999 |
| Species comparison in P450 induction: effects of dexamethasone, omeprazole, and rifampin on P450 isoforms 1A and 3A in primary cultured hepatocytes from man, Sprague–Dawley rat … C Lu, AP Li Chemico-biological interactions 134 (3), 271-281, 2001 | 253 | 2001 |
| Human hepatocytes: isolation, cryopreservation and applications in drug development AP Li Chemico-biological interactions 168 (1), 16-29, 2007 | 243 | 2007 |
| Effects of organic solvents on the activities of cytochrome P450 isoforms, UDP-dependent glucuronyl transferase, and phenol sulfotransferase in human hepatocytes J Easterbrook, C Lu, Y Sakai, AP Li Drug Metabolism and Disposition 29 (2), 141-144, 2001 | 226 | 2001 |
| Primary human hepatocytes as a tool for the evaluation of structure—activity relationship in cytochrome P450 induction potential of xenobiotics: evaluation of rifampin … AP Li, MK Reith, A Rasmussen, JC Gorski, SD Hall, L Xu, DL Kaminski, ... Chemico-biological interactions 107 (1-2), 17-30, 1997 | 212 | 1997 |
| A review of the common properties of drugs with idiosyncratic hepatotoxicity and the “multiple determinant hypothesis” for the manifestation of idiosyncratic drug toxicity AP Li Chemico-biological interactions 142 (1-2), 7-23, 2002 | 210 | 2002 |
| Optimization of cryopreservation procedures for rat and human hepatocytes LJ Loretz, AP Li, MW Flye, AGE Wilson Xenobiotica 19 (5), 489-498, 1989 | 209 | 1989 |
| Present status of the application of cryopreserved hepatocytes in the evaluation of xenobiotics: consensus of an international expert panel AP Li, PD Gorycki, JG Hengstler, GL Kedderis, HG Koebe, R Rahmani, ... Chemico-biological interactions 121 (1), 117-123, 1999 | 185 | 1999 |
| Preclinical evaluation of drug—drug interaction potential: present status of the application of primary human hepatocytes in the evaluation of cytochrome P450 induction AP Li, P Maurel, MJ Gomez-Lechon, LC Cheng, M Jurima-Romet Chemico-biological interactions 107 (1-2), 5-16, 1997 | 180 | 1997 |
| A novel in vitro system, the integrated discrete multiple organ cell culture (IdMOC) system, for the evaluation of human drug toxicity: comparative cytotoxicity of tamoxifen … AP Li, C Bode, Y Sakai Chemico-biological interactions 150 (1), 129-136, 2004 | 137 | 2004 |
| Function of uptake transporters for taurocholate and estradiol 17β-d-glucuronide in cryopreserved human hepatocytes Y Shitara, AP Li, Y Kato, C Lu, K Ito, T Itoh, Y Sugiyama Drug metabolism and pharmacokinetics 18 (1), 33-41, 2003 | 135 | 2003 |
| Isolation and culturing of hepatocytes from human livers AP Li, MA Roque, DJ Beck, DL Kaminski Journal of tissue culture methods 14, 139-145, 1992 | 134 | 1992 |
| Applications of microarrays with toxicologically relevant genes (tox genes) for the evaluation of chemical toxicants in Sprague Dawley rats in vivo and human hepatocytes in vitro LD Kier, R Neft, L Tang, R Suizu, T Cook, K Onsurez, K Tiegler, Y Sakai, ... Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 549 (1 …, 2004 | 124 | 2004 |
| Mutagenicity of mono-, di-and tri-nitropyrenes in Chinese hamster ovary cells AP Li, JS Dutcher Mutation Research Letters 119 (3-4), 387-392, 1983 | 117 | 1983 |
| In Vitro Human Tissue Models in Risk Assessment: Report of a Consensus-Building Workshop JT MacGregor, JM Collins, Y Sugiyama, CA Tyson, J Dean, L Smith, ... Toxicological Sciences 59 (1), 17-36, 2001 | 114 | 2001 |
