Fen1 mutations result in autoimmunity, chronic inflammation and cancers L Zheng, H Dai, M Zhou, M Li, P Singh, J Qiu, W Tsark, Q Huang, ... Nature medicine 13 (7), 812-819, 2007 | 259 | 2007 |
Human DNA2 is a mitochondrial nuclease/helicase for efficient processing of DNA replication and repair intermediates L Zheng, M Zhou, Z Guo, H Lu, L Qian, H Dai, J Qiu, E Yakubovskaya, ... Molecular cell 32 (3), 325-336, 2008 | 255 | 2008 |
Removal of oxidative DNA damage via FEN1-dependent long-patch base excision repair in human cell mitochondria P Liu, L Qian, JS Sung, NC de Souza-Pinto, L Zheng, DF Bogenhagen, ... Molecular and cellular biology 28 (16), 4975-4987, 2008 | 241 | 2008 |
Functional regulation of FEN1 nuclease and its link to cancer L Zheng, J Jia, LD Finger, Z Guo, C Zer, B Shen Nucleic acids research 39 (3), 781-794, 2011 | 206 | 2011 |
Okazaki fragment maturation: nucleases take centre stage L Zheng, B Shen Journal of molecular cell biology 3 (1), 23-30, 2011 | 187 | 2011 |
Novel function of the flap endonuclease 1 complex in processing stalled DNA replication forks L Zheng, M Zhou, Q Chai, J Parrish, D Xue, SM Patrick, JJ Turchi, ... EMBO reports 6 (1), 83-89, 2005 | 174 | 2005 |
Multiple but dissectible functions of FEN‐1 nucleases in nucleic acid processing, genome stability and diseases B Shen, P Singh, R Liu, J Qiu, L Zheng, LD Finger, S Alas Bioessays 27 (7), 717-729, 2005 | 168 | 2005 |
Reciprocal regulation of Akt and Oct4 promotes the self-renewal and survival of embryonal carcinoma cells Y Lin, Y Yang, W Li, Q Chen, J Li, X Pan, L Zhou, C Liu, C Chen, J He, ... Molecular cell 48 (4), 627-640, 2012 | 163 | 2012 |
Distinct Ca2+ binding properties of novel C2 domains of plant phospholipase Dα and β L Zheng, R Krishnamoorthi, M Zolkiewski, X Wang Journal of Biological Chemistry 275 (26), 19700-19706, 2000 | 160 | 2000 |
Mammalian DNA2 helicase/nuclease cleaves G‐quadruplex DNA and is required for telomere integrity W Lin, S Sampathi, H Dai, C Liu, M Zhou, J Hu, Q Huang, J Campbell, ... The EMBO journal 32 (10), 1425-1439, 2013 | 152 | 2013 |
Methylation of FEN1 suppresses nearby phosphorylation and facilitates PCNA binding Z Guo, L Zheng, H Xu, H Dai, M Zhou, MR Pascua, QM Chen, B Shen Nature chemical biology 6 (10), 766-773, 2010 | 142 | 2010 |
Mutations in DNA2 link progressive myopathy to mitochondrial DNA instability D Ronchi, A Di Fonzo, W Lin, A Bordoni, C Liu, E Fassone, S Pagliarani, ... The American Journal of Human Genetics 92 (2), 293-300, 2013 | 139 | 2013 |
Human 3-methyladenine-DNA glycosylase: effect of sequence context on excision, association with PCNA, and stimulation by AP endonuclease L Xia, L Zheng, HW Lee, SE Bates, L Federico, B Shen, TR O'Connor Journal of molecular biology 346 (5), 1259-1274, 2005 | 107 | 2005 |
Sequential posttranslational modifications program FEN1 degradation during cell-cycle progression Z Guo, J Kanjanapangka, N Liu, S Liu, C Liu, Z Wu, Y Wang, T Loh, ... Molecular cell 47 (3), 444-456, 2012 | 105 | 2012 |
Polyploid cells rewire DNA damage response networks to overcome replication stress-induced barriers for tumour progression L Zheng, H Dai, M Zhou, X Li, C Liu, Z Guo, X Wu, J Wu, C Wang, J Zhong, ... Nature communications 3 (1), 815, 2012 | 85 | 2012 |
Disruption of the FEN-1/PCNA interaction results in DNA replication defects, pulmonary hypoplasia, pancytopenia, and newborn lethality in mice L Zheng, H Dai, J Qiu, Q Huang, B Shen Molecular and cellular biology 27 (8), 3176-3186, 2007 | 77 | 2007 |
Activation of plant phospholipase Dβ by phosphatidylinositol 4, 5-bisphosphate: characterization of binding site and mode of action L Zheng, J Shan, R Krishnamoorthi, X Wang Biochemistry 41 (14), 4546-4553, 2002 | 66 | 2002 |
Multiple roles of DNA2 nuclease/helicase in DNA metabolism, genome stability and human diseases L Zheng, Y Meng, JL Campbell, B Shen Nucleic acids research 48 (1), 16-35, 2020 | 65 | 2020 |
A selective small molecule DNA2 inhibitor for sensitization of human cancer cells to chemotherapy W Liu, M Zhou, Z Li, H Li, P Polaczek, H Dai, Q Wu, C Liu, KK Karanja, ... EBioMedicine 6, 73-86, 2016 | 65 | 2016 |
JMJD1B demethylates H4R3me2s and H3K9me2 to facilitate gene expression for development of hematopoietic stem and progenitor cells S Li, S Ali, X Duan, S Liu, J Du, C Liu, H Dai, M Zhou, L Zhou, L Yang, ... Cell reports 23 (2), 389-403, 2018 | 64 | 2018 |