作者
Craig S Anderson, Yining Huang, Richard I Lindley, Xiaoying Chen, Hisatomi Arima, Guofang Chen, Qiang Li, Laurent Billot, Candice Delcourt, Philip M Bath, Joseph P Broderick, Andrew M Demchuk, Geoffrey A Donnan, Alice C Durham, Pablo M Lavados, Tsong-Hai Lee, Christopher Levi, Sheila O Martins, Veronica V Olavarria, Jeyaraj D Pandian, Mark W Parsons, Octavio M Pontes-Neto, Stefano Ricci, Shoichiro Sato, Vijay K Sharma, Federico Silva, Lili Song, Nguyen H Thang, Joanna M Wardlaw, Ji-Guang Wang, Xia Wang, Mark Woodward, John Chalmers, Thompson G Robinson, Craig S Anderson, Richard I Lindley, Philip M Bath, Joseph P Broderick, Andrew M Demchuk, Geoffrey A Donnan, Alice C Durham, Pablo M Lavados, Sheila O Martins, Veronica V Olavarria, Jeyaraj D Pandian, Mark W Parsons, Octavio M Pontes-Neto, Vijay K Sharma, Nguyen H Thang, Joanna M Wardlaw, Thompson G Robinson, Jong S Kim, Christian Stapf, R John Simes, Graeme J Hankey, Peter Sandercock, Marie-Germaine Bousser, KS Lawrence Wong, Anish Scaria, Yoichiro Hirakawa, Tom J Moullaali, Cheryl Carcel, Penny Gordon, Sully X Fuentes-Patarroyo, Dino Benito, Ruiqi Chen, Yongjun Cao, Amy Kunchok, Stephen Winters, Shelagh Coutts, Sohei Yoshimura, Shoujiang You, Jie Yang, Guojun Wu, Shihong Zhang, Lisa Manning, Amit Mistri, Victoria Haunton, Jatinder Minhas, Alejandra Malavera, Joyce Lim, Leibo Liu, Namrata N Kumar, Nicole Tay, Kerry Jenson, Sarah Richtering, Sharon Tucker, Elizabeth Knight, Elizaveta Ivanova, Emma Thembani, Elizabeth Odgers, Elizabeth Sanders, Sabrina Small, Ruchita Vaghasiya, Manuela Armenis, Paul Donnelly, Merza A Baig, Nick Blacklock, Bala Naidu, Helen Monaghan, Phillipa Smith, Parisa Glass, Xuejie Bai, Qiancheng Li, Pingping Zhu, Liang Kong, Ruihong He, He Zhao, Jiajie Lv, Haijing Jia, Zhen Xi, Yuhan Cong, Buliang Cui, Hua Deng, Ying Guo, Lingyu He, Ruolan Jia, Nan Li, Wei Li, Mengxiao Liu, Meng Zhang, Ziwei Xu, Ting Zhang, Yan Zhao, Philip Gregory, Yunjeong In, Su J Kim, Jung E Ahn, Sul H Kim, Young L Hong, Francisca González-McCawley, Magda CO Martins, Bernardita Portales, Ching-Yi Wang, Shan-Jen Ryu, Hardeep Aujla, Sue Lewin, Tracy Kumar, Sara Barrows, Ahtasam Ebraimo, Hong H Uyen, Nguyen A Giang, Le TM Linh, Le TT An, Do M Phuong, Pham VB Ngoc, Nguyen M Hang, Nguyen TB Tran, Ha TT Hien, Mai B Yen
发表日期
2019/3/2
期刊
The Lancet
卷号
393
期号
10174
页码范围
877-888
出版商
Elsevier
简介
Background
Systolic blood pressure of more than 185 mm Hg is a contraindication to thrombolytic treatment with intravenous alteplase in patients with acute ischaemic stroke, but the target systolic blood pressure for optimal outcome is uncertain. We assessed intensive blood pressure lowering compared with guideline-recommended blood pressure lowering in patients treated with alteplase for acute ischaemic stroke.
Methods
We did an international, partial-factorial, open-label, blinded-endpoint trial of thrombolysis-eligible patients (age ≥18 years) with acute ischaemic stroke and systolic blood pressure 150 mm Hg or more, who were screened at 110 sites in 15 countries. Eligible patients were randomly assigned (1:1, by means of a central, web-based program) within 6 h of stroke onset to receive intensive (target systolic blood pressure 130–140 mm Hg within 1 h) or guideline (target systolic blood pressure <180 …
学术搜索中的文章
CS Anderson, Y Huang, RI Lindley, X Chen, H Arima… - The Lancet, 2019