作者
Shawn D Aaron, Katherine L Vandemheen, Dean Fergusson, François Maltais, Jean Bourbeau, Roger Goldstein, Meyer Balter, Denis O'Donnell, Andrew McIvor, Sat Sharma, Graham Bishop, John Anthony, Robert Cowie, Stephen Field, Andrew Hirsch, Paul Hernandez, Robert Rivington, Jeremy Road, Victor Hoffstein, Richard Hodder, Darcy Marciniuk, David McCormack, George Fox, Gerard Cox, Henry B Prins, Gordon Ford, Dominique Bleskie, Steve Doucette, Irvin Mayers, Kenneth Chapman, Noe Zamel, Mark FitzGerald, Canadian Thoracic Society/Canadian Respiratory Clinical Research Consortium
发表日期
2007/4/17
期刊
Annals of internal medicine
卷号
146
期号
8
页码范围
545-555
出版商
American College of Physicians
简介
Background
Treatment of moderate or severe chronic obstructive pulmonary disease (COPD) with combinations of inhaled corticosteroids, long-acting β-agonists, and long-acting anticholinergic bronchodilators is common but unstudied.
Objective
To determine whether combining tiotropium with salmeterol or fluticasone–salmeterol improves clinical outcomes in adults with moderate to severe COPD compared with tiotropium alone.
Design
Randomized, double-blind, placebo-controlled trial conducted from October 2003 to January 2006.
Setting
27 academic and community medical centers in Canada.
Patients
449 patients with moderate or severe COPD.
Intervention
1 year of treatment with tiotropium plus placebo, tiotropium plus salmeterol, or …
引用总数
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SD Aaron, KL Vandemheen, D Fergusson, F Maltais… - Annals of internal medicine, 2007